STRINGSTRING
AIW12638.1 AIW12638.1 ilvA ilvA ilvD ilvD ilvE ilvE AIW12642.1 AIW12642.1 AIW12643.1 AIW12643.1 AIW12668.1 AIW12668.1 pckA pckA AIW12752.1 AIW12752.1 AIW12792.1 AIW12792.1 AIW12793.1 AIW12793.1 acsA acsA AIW12924.1 AIW12924.1 AIW12967.1 AIW12967.1 plsY plsY aceE aceE aceF aceF AIW13046.1 AIW13046.1 AIW13049.1 AIW13049.1 AIW13063.1 AIW13063.1 glpD glpD AIW13218.1 AIW13218.1 glpK glpK AIW13224.1 AIW13224.1 AIW13225.1 AIW13225.1 AIW13297.1 AIW13297.1 AIW13321.1 AIW13321.1 gltA gltA AIW13389.1 AIW13389.1 sdhD sdhD sdhA sdhA sdhB sdhB AIW13393.1 AIW13393.1 AIW13394.1 AIW13394.1 sucC sucC sucD sucD AIW13477.1 AIW13477.1 accD accD fadI fadI fadJ fadJ AIW13639.1 AIW13639.1 AIW13650.1 AIW13650.1 AIW13709.1 AIW13709.1 fabV fabV AIW13834.1 AIW13834.1 AIW13838.1 AIW13838.1 AIW13905.1 AIW13905.1 AIW13988.1 AIW13988.1 prpB prpB AIW13990.1 AIW13990.1 AIW13991.1 AIW13991.1 AIW13992.1 AIW13992.1 prpE prpE AIW14007.1 AIW14007.1 fabA fabA AIW14110.1 AIW14110.1 AIW14176.1 AIW14176.1 AIW14198.1 AIW14198.1 accD-2 accD-2 AIW14304.1 AIW14304.1 maeA maeA AIW14445.1 AIW14445.1 ackA ackA AIW14489.1 AIW14489.1 AIW14558.1 AIW14558.1 AIW14569.1 AIW14569.1 fabG fabG AIW14572.1 AIW14572.1 fabH fabH plsX plsX AIW14598.1 AIW14598.1 AIW14652.1 AIW14652.1 AIW14710.1 AIW14710.1 fadE fadE accA accA ilvH ilvH AIW15071.1 AIW15071.1 leuA leuA leuB leuB leuC leuC leuD leuD AIW15098.1 AIW15098.1 AIW15099.1 AIW15099.1 oadG oadG AIW15116.1 AIW15116.1 mdh mdh AIW15131.1 AIW15131.1 AIW15206.1 AIW15206.1 AIW15273.1 AIW15273.1 ppc ppc gpsA gpsA AIW15308.1 AIW15308.1 AIW15309.1 AIW15309.1 frdC frdC frdD frdD AIW15320.1 AIW15320.1 sthA sthA AIW15340.1 AIW15340.1 plsB plsB ilvC ilvC fadB fadB fadA fadA AIW15549.1 AIW15549.1 AIW15603.1 AIW15603.1 AIW15604.1 AIW15604.1 AIW15712.1 AIW15712.1 AIW15713.1 AIW15713.1 AIW15715.1 AIW15715.1 fabG-2 fabG-2 AIW15717.1 AIW15717.1 AIW15718.1 AIW15718.1 AIW15719.1 AIW15719.1 AIW15720.1 AIW15720.1 AIW15721.1 AIW15721.1 AIW15722.1 AIW15722.1 AIW15724.1 AIW15724.1 AIW15725.1 AIW15725.1 AIW15726.1 AIW15726.1 AIW15727.1 AIW15727.1 acpP-2 acpP-2 AIW15729.1 AIW15729.1 AIW15730.1 AIW15730.1 AIW15731.1 AIW15731.1 AIW15732.1 AIW15732.1 AIW15733.1 AIW15733.1 AIW15734.1 AIW15734.1 AIW15814.1 AIW15814.1 AIW15815.1 AIW15815.1 AIW15816.1 AIW15816.1 gcvP gcvP AIW15964.1 AIW15964.1 AIW15965.1 AIW15965.1 AIW16012.1 AIW16012.1 aspA-2 aspA-2 AIW16100.1 AIW16100.1 AIW16156.1 AIW16156.1 lldD lldD AIW16181.1 AIW16181.1 AIW16186.1 AIW16186.1 AIW16314.1 AIW16314.1 AIW16344.1 AIW16344.1 fabV-2 fabV-2 AIW16418.1 AIW16418.1 AIW16419.1 AIW16419.1 ackA-2 ackA-2 fabH-2 fabH-2 dld dld fabG-3 fabG-3 AIW16525.1 AIW16525.1 AIW16526.1 AIW16526.1 AIW16527.1 AIW16527.1 AIW16528.1 AIW16528.1 AIW16529.1 AIW16529.1 AIW16530.1 AIW16530.1 AIW16532.1 AIW16532.1 AIW16533.1 AIW16533.1 AIW16534.1 AIW16534.1 AIW16535.1 AIW16535.1 pdhA pdhA AIW16546.1 AIW16546.1 AIW16547.1 AIW16547.1 AIW16548.1 AIW16548.1 AIW16549.1 AIW16549.1 AIW16550.1 AIW16550.1 AIW16657.1 AIW16657.1 AIW17034.1 AIW17034.1 AIW17035.1 AIW17035.1 AIW17036.1 AIW17036.1 AIW17037.1 AIW17037.1 AIW17038.1 AIW17038.1 AIW17039.1 AIW17039.1 AIW17040.1 AIW17040.1 AIW17041.1 AIW17041.1 AIW17068.1 AIW17068.1 AIW17070.1 AIW17070.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIW12638.1Quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (515 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (613 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (315 aa)
AIW12642.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (94 aa)
AIW12643.1Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
AIW12668.1Anhydrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (543 aa)
AIW12752.13-oxoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
AIW12792.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
AIW12793.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)
AIW12924.1Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (246 aa)
AIW12967.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
plsYGlycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (203 aa)
aceEPyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
aceFPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (632 aa)
AIW13046.1E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
AIW13049.1Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (222 aa)
AIW13063.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (862 aa)
glpDGlycerol-3-phosphate dehydrogenase; In Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (517 aa)
AIW13218.1Transcriptional regulator; Represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (505 aa)
AIW13224.1Malate synthase; Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
AIW13225.1Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
AIW13297.1Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (256 aa)
AIW13321.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (338 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
AIW13389.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
sdhDSuccinate dehydrogenase; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (114 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
AIW13393.12-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (941 aa)
AIW13394.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
AIW13477.1FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (403 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (308 aa)
fadI3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (435 aa)
fadJMultifunctional fatty acid oxidation complex subunit alpha; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (707 aa)
AIW13639.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (741 aa)
AIW13650.1Formate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AIW13709.1acyl-CoA dehydrogenase; Functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (763 aa)
fabVtrans-2-enoyl-CoA reductase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (400 aa)
AIW13834.1Glycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (590 aa)
AIW13838.1Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
AIW13905.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1010 aa)
AIW13988.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (298 aa)
AIW13990.1Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
AIW13991.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (863 aa)
AIW13992.13-methylitaconate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
prpECatalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (625 aa)
AIW14007.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
fabA3-hydroxydecanoyl-ACP dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa)
AIW14110.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
AIW14176.1Formate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
AIW14198.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (320 aa)
accD-2acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa)
AIW14304.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
maeAMalate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
AIW14445.1Pyruvate formate-lyase; Formate acetyltransferase; catalyzes the formation of formate and acetyl-CoA from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (758 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
AIW14489.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (721 aa)
AIW14558.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AIW14569.13-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)
fabG3-ketoacyl-ACP reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
AIW14572.1Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
fabH3-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa)
plsXPhosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (341 aa)
AIW14598.12-hydroxy-3-oxopropionate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
AIW14652.1Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (900 aa)
AIW14710.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
fadEacyl-CoA dehydrogenase; Functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (817 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
ilvHAcetolactate synthase 3 regulatory subunit; With IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
AIW15071.1Acetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
AIW15098.1glutaconyl-CoA decarboxylase subunit beta; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (376 aa)
AIW15099.1Oxaloacetate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (594 aa)
oadGOxaloacetate decarboxylase subunit gamma; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (85 aa)
AIW15116.1Glycerate dehydrogenase; Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (310 aa)
AIW15131.1Beta-galactosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AIW15206.1Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (119 aa)
AIW15273.1Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (226 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (877 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (343 aa)
AIW15308.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (605 aa)
AIW15309.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
frdCFumarate reductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (127 aa)
frdDFumarate reductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (125 aa)
AIW15320.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
sthAPyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
AIW15340.1Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (120 aa)
plsBGlycerol-3-phosphate acyltransferase; PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPAT/DAPAT family. (825 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (494 aa)
fadBMultifunctional fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
fadA3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (391 aa)
AIW15549.1Carboxyvinyl-carboxyphosphonate phosphorylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
AIW15603.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
AIW15604.1Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AIW15712.1Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (70 aa)
AIW15713.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
AIW15715.1FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (407 aa)
fabG-23-ketoacyl-ACP reductase; Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
AIW15717.13-hydroxydecanoyl-ACP dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
AIW15718.13-oxoacyl-ACP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (395 aa)
AIW15719.1Lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
AIW15720.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (783 aa)
AIW15721.1Membrane protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (202 aa)
AIW15722.14-hydroxybenzoyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
AIW15724.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (570 aa)
AIW15725.13-hydroxyacyl-ACP dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
AIW15726.1AMP-fatty acid ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
AIW15727.1DNA gyrase subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
acpP-2Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (85 aa)
AIW15729.1Acyl carrier protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
AIW15730.1Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
AIW15731.13-oxoacyl-ACP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
AIW15732.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AIW15733.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
AIW15734.1FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
AIW15814.13-oxoacid CoA-transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (524 aa)
AIW15815.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
AIW15816.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
AIW15964.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa)
AIW15965.1Phosphoenolpyruvate synthase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (277 aa)
AIW16012.1acetoacetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (666 aa)
aspA-2Aspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
AIW16100.12-hydroxy-3-oxopropionate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AIW16156.1Catalyzes the oxidation of acetaldehyde, benzaldehyde, propionaldehyde and other aldehydes; Derived by automated computational analysis using gene prediction method: Protein Homology. (506 aa)
lldDLactate dehydrogenase; Flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
AIW16181.1Lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (563 aa)
AIW16186.1Lactate dehydrogenase; Fermentative; catalyzes the formationof pyruvate from lactate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
AIW16314.1Carbonic anhydrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
AIW16344.1Formate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
fabV-2trans-2-enoyl-CoA reductase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (396 aa)
AIW16418.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
AIW16419.13-ketoacyl-ACP reductase; Catalyzes the conversion of 3-hydroxyacyl-CoA to 3-oxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
fabH-23-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (360 aa)
dldLactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (568 aa)
fabG-33-ketoacyl-ACP reductase; Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
AIW16525.13-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HIBADH-related family. (301 aa)
AIW16526.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
AIW16527.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa)
AIW16528.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
AIW16529.1Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
AIW16530.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
AIW16532.1isovaleryl-CoA dehydrogenase; Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
AIW16533.1methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
AIW16534.1Catalyzes the hydration of gamma-carboxygeranoyl-CoA to 3-hydroxy-gamma-carboxygeranoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
AIW16535.1hydroxymethylglutaryl-CoA lyase; Catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
pdhAABC transporter permease; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (368 aa)
AIW16546.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
AIW16547.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
AIW16548.1Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
AIW16549.1Electron transporter RnfB; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
AIW16550.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (552 aa)
AIW16657.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
AIW17034.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (378 aa)
AIW17035.1Gluconate:proton symporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
AIW17036.1XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
AIW17037.1Tartronate semialdehyde reductase; NADH-dependent; catalyzed the reversible formation of glycerate from tartronate semialdehyde; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
AIW17038.1Hydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the hyi family. (258 aa)
AIW17039.1Glyoxylate carboligase; Catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (591 aa)
AIW17040.1Malate synthase; Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; Derived by automated computational analysis using gene prediction method: Protein Homology. (542 aa)
AIW17041.1GlcG protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
AIW17068.1Sugar dehydrogenase; Converts glucose to D-glucono-1,5 lactone; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
AIW17070.1MFS transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
Your Current Organism:
Vibrio tubiashii
NCBI taxonomy Id: 1051646
Other names: V. tubiashii ATCC 19109, Vibrio tubiashii ATCC 19109, Vibrio tubiashii LMG 10396, Vibrio tubiashii NBRC 15644, Vibrio tubiashii str. ATCC 19109, Vibrio tubiashii strain ATCC 19109
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