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yveK yveK ecfT ecfT thiC thiC GYO_1244 GYO_1244 GYO_1339 GYO_1339 GYO_1470 GYO_1470 GYO_1471 GYO_1471 thiO thiO thiS thiS thiG thiG GYO_1475 GYO_1475 GYO_1476 GYO_1476 GYO_1644 GYO_1644 GYO_1645 GYO_1645 GYO_1646 GYO_1646 GYO_1647 GYO_1647 GYO_1882 GYO_1882 GYO_2053 GYO_2053 tdh tdh GYO_2055 GYO_2055 GYO_2537 GYO_2537 GYO_2876 GYO_2876 GYO_3265 GYO_3265 GYO_3266 GYO_3266 bioI bioI bioB bioB bioD bioD bioF bioF bioA bioA bioW bioW GYO_3280 GYO_3280 GYO_3281 GYO_3281 GYO_3377 GYO_3377 GYO_3495 GYO_3495 GYO_3562 GYO_3562 GYO_3563 GYO_3563 thiD thiD thiE thiE thiM thiM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yveKCobalt import ATP-binding protein CbiO 1; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (281 aa)
ecfTCobalt transport family protein; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (265 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (590 aa)
GYO_1244Iminodiacetate oxidase. (375 aa)
GYO_1339Conserved hypothetical protein. (186 aa)
GYO_1470Tena/thi-4 family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (235 aa)
GYO_1471Regulatory protein TenI. (205 aa)
thiOGlycine oxidase ThiO. (369 aa)
thiSThiamine biosynthesis protein ThiS. (67 aa)
thiGThiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (254 aa)
GYO_1475Molybdopterin biosynthesis protein MoeB. (336 aa)
GYO_1476Phosphomethylpyrimidine kinase. (271 aa)
GYO_1644Cobalt transport protein. (254 aa)
GYO_1645YkoD. (546 aa)
GYO_1646YkoE. (199 aa)
GYO_1647Ykof-related family protein. (200 aa)
GYO_1882Peptidase, ArgE/DapE family protein. (426 aa)
GYO_2053Hypothetical protein. (38 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)
GYO_20558-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (392 aa)
GYO_2537Hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family. (189 aa)
GYO_2876Sulfide:quinone oxidoreductase. (399 aa)
GYO_3265Hypothetical protein. (50 aa)
GYO_3266NAD dependent epimerase/dehydratase family protein. (253 aa)
bioICytochrome P450. (395 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (389 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (448 aa)
bioW6-carboxyhexanoate--CoA ligase; Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. (244 aa)
GYO_3280Transposase. (110 aa)
GYO_3281Transposase. (266 aa)
GYO_3377Putative proton-coupled thiamine transporter YuaJ. (192 aa)
GYO_3495Transmembranal protein BioY. (200 aa)
GYO_3562Endo/excinuclease amino domain protein. (77 aa)
GYO_3563Iminodiacetate oxidase. (374 aa)
thiDPhosphomethylpyrimidine kinase. (232 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (222 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (272 aa)
Your Current Organism:
Bacillus subtilis spizizenii
NCBI taxonomy Id: 1052585
Other names: B. subtilis subsp. spizizenii TU-B-10, Bacillus subtilis subsp. spizizenii TU-B-10, Bacillus subtilis subsp. spizizenii str. TU-B-10, Bacillus subtilis subsp. spizizenii strain TU-B-10
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