STRINGSTRING
pdxS pdxS pdxT pdxT prs prs GYO_0360 GYO_0360 glmM glmM glmS glmS ptsG ptsG nagB nagB GYO_0485 GYO_0485 hxlB hxlB hxlA hxlA GYO_0560 GYO_0560 GYO_0561 GYO_0561 GYO_0609 GYO_0609 GYO_0610 GYO_0610 GYO_0615 GYO_0615 GYO_0616 GYO_0616 mtlD mtlD GYO_0634 GYO_0634 GYO_0709 GYO_0709 GYO_0747 GYO_0747 GYO_0839 GYO_0839 GYO_0840 GYO_0840 GYO_0841 GYO_0841 GYO_0842 GYO_0842 GYO_0843 GYO_0843 GYO_0844 GYO_0844 GYO_0845 GYO_0845 GYO_0846 GYO_0846 GYO_0871 GYO_0871 GYO_0873 GYO_0873 GYO_1037 GYO_1037 treP treP treC treC treR treR GYO_1048 GYO_1048 GYO_1503 GYO_1503 GYO_1504 GYO_1504 GYO_1505 GYO_1505 GYO_1620 GYO_1620 glcT glcT GYO_1723 GYO_1723 GYO_1724 GYO_1724 ptsI ptsI GYO_1774 GYO_1774 pfkB pfkB GYO_1776 GYO_1776 tkt tkt GYO_2211 GYO_2211 pdxT-2 pdxT-2 pdxS-2 pdxS-2 GYO_2293 GYO_2293 GYO_2449 GYO_2449 deoB deoB GYO_2597 GYO_2597 zwf zwf GYO_2631 GYO_2631 GYO_2843 GYO_2843 GYO_2884 GYO_2884 GYO_2885 GYO_2885 GYO_2886 GYO_2886 GYO_2937 GYO_2937 GYO_2938 GYO_2938 GYO_2939 GYO_2939 GYO_2940 GYO_2940 GYO_2941 GYO_2941 GYO_3152 GYO_3152 pyk pyk pfkA pfkA pgi pgi eno eno gpmI gpmI tpiA tpiA pgk pgk GYO_3718 GYO_3718 GYO_3780 GYO_3780 GYO_3781 GYO_3781 nagA nagA nagB-2 nagB-2 GYO_3840 GYO_3840 GYO_3938 GYO_3938 GYO_4066 GYO_4066 rpiB rpiB GYO_4068 GYO_4068 glpX glpX talC talC fba fba GYO_4194 GYO_4194 GYO_4195 GYO_4195 GYO_4235 GYO_4235 GYO_4238 GYO_4238 sacY sacY GYO_4257 GYO_4257 GYO_4258 GYO_4258 GYO_4259 GYO_4259 GYO_4260 GYO_4260 GYO_4261 GYO_4261 GYO_4314 GYO_4314 GYO_4315 GYO_4315 licT licT GYO_4333 GYO_4333 GYO_4334 GYO_4334 deoC deoC GYO_4407 GYO_4407 GYO_4408 GYO_4408 gntK gntK GYO_4410 GYO_4410 GYO_4411 GYO_4411 GYO_4418 GYO_4418 GYO_4419 GYO_4419 fbp fbp
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdxSPyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa)
GYO_0360YbbF. (455 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (448 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (600 aa)
ptsGPts system, glucose-specific iibc component. (631 aa)
nagBGlucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (249 aa)
GYO_0485Glucose 1-dehydrogenase. (258 aa)
hxlB6-phospho 3-hexuloisomerase. (185 aa)
hxlA3-hexulose-6-phosphate synthase. (210 aa)
GYO_0560HTH-type transcriptional activator HxlR. (120 aa)
GYO_0561Hypothetical protein. (38 aa)
GYO_0609Glucose uptake protein GlcU. (287 aa)
GYO_0610Glucose 1-dehydrogenase. (261 aa)
GYO_0615Pts system mannitol-specific eiicba component. (477 aa)
GYO_0616Pts system mannitol-specific eiicba component. (143 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase. (373 aa)
GYO_0634HTH domain family. (696 aa)
GYO_0709Phosphocarrier protein HPr. (91 aa)
GYO_0747Phosphocarrier protein HPr. (91 aa)
GYO_0839Cellobiose-specific phosphotransferase enzyme IIB component. (103 aa)
GYO_0840Lichenan-specific phosphotransferase enzyme IIA component. (110 aa)
GYO_0841PTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (442 aa)
GYO_0842Beta-glucosidase; Belongs to the glycosyl hydrolase 1 family. (465 aa)
GYO_0843Transcriptional regulator. (237 aa)
GYO_0844Fructokinase. (299 aa)
GYO_0845Mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (315 aa)
GYO_0846Mannan endo-1,4-beta-mannosidase; Belongs to the glycosyl hydrolase 26 family. (362 aa)
GYO_0871Sorbitol dehydrogenase. (377 aa)
GYO_0873Fructokinase. (320 aa)
GYO_1037PTS system N-acetylglucosamine-specific EIICBA component. (452 aa)
trePPts system, trehalose-specific iibc component. (470 aa)
treCAlpha,alpha-phosphotrehalase. (515 aa)
treRTrehalose operon repressor. (238 aa)
GYO_1048NfnB protein. (221 aa)
GYO_1503HTH domain family. (648 aa)
GYO_1504Phosphotransferase system. (650 aa)
GYO_1505Mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (315 aa)
GYO_1620YkgB. (348 aa)
glcTTranscription antiterminator, GlcT. (281 aa)
GYO_1723PTS system glucose-specific EIICBA component. (699 aa)
GYO_1724Phosphocarrier protein HPr. (88 aa)
ptsIPhosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (570 aa)
GYO_1774Transcriptional regulator. (251 aa)
pfkB1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (303 aa)
GYO_1776Fructose permease IIC component. (634 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (667 aa)
GYO_2211Conserved domain protein. (76 aa)
pdxT-2Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa)
pdxS-2Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa)
GYO_2293Fructokinase; Belongs to the carbohydrate kinase PfkB family. (333 aa)
GYO_2449Glucose-specific phosphotransferase enzyme IIA component. (168 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (394 aa)
GYO_2597ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. (185 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa)
GYO_26316-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (469 aa)
GYO_28436-phosphogluconate dehydrogenase. (297 aa)
GYO_2884Transcription antiterminator. (282 aa)
GYO_28856-phospho-beta-glucosidase; Belongs to the glycosyl hydrolase 1 family. (468 aa)
GYO_2886Pts system beta-glucoside-specific eiibca component. (617 aa)
GYO_2937Glycosyl hydrolases family 32; Belongs to the glycosyl hydrolase 32 family. (675 aa)
GYO_2938Fructose permease IID component. (275 aa)
GYO_2939Fructose permease IIC component. (269 aa)
GYO_2940Fructose-specific phosphotransferase enzyme IIB component. (162 aa)
GYO_2941Fructose-specific phosphotransferase enzyme IIA component. (146 aa)
GYO_3152Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (558 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (450 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (511 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
GYO_3718Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
GYO_3780Levansucrase; Belongs to the glycosyl hydrolase 68 family. (473 aa)
GYO_3781YveB; Belongs to the glycosyl hydrolase 32 family. (516 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase. (396 aa)
nagB-2Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (242 aa)
GYO_3840Transcriptional regulator. (243 aa)
GYO_3938Mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (316 aa)
GYO_4066Conserved hypothetical protein; Belongs to the UPF0340 family. (180 aa)
rpiBRibose 5-phosphate isomerase B. (149 aa)
GYO_4068Hypothetical protein. (40 aa)
glpXFructose-1,6-bisphosphatase, class II. (321 aa)
talCTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (212 aa)
fbaFructose-1,6-bisphosphate aldolase, class II. (285 aa)
GYO_4194Sucrose-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (479 aa)
GYO_4195PTS system sucrose-specific EIIBC component. (461 aa)
GYO_4235PTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (440 aa)
GYO_4238Pts system, sucrose-specific iibc component. (459 aa)
sacYLevansucrase and sucrase synthesis operon antiterminator. (280 aa)
GYO_42576-phospho-beta-glucosidase. (442 aa)
GYO_4258Lichenan-specific phosphotransferase enzyme IIA component. (110 aa)
GYO_4259PTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (452 aa)
GYO_4260Lichenan-specific phosphotransferase enzyme IIB component. (102 aa)
GYO_4261HTH domain family. (641 aa)
GYO_4314Beta-glucosidase; Belongs to the glycosyl hydrolase 1 family. (473 aa)
GYO_4315Pts system beta-glucoside-specific eiibca component. (610 aa)
licTTranscription antiterminator LicT. (277 aa)
GYO_4333Beta-glucosidase; Belongs to the glycosyl hydrolase 1 family. (469 aa)
GYO_4334Pts system beta-glucoside-specific eiibca component. (612 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa)
GYO_4407Glycerate kinase 2; Belongs to the glycerate kinase type-1 family. (382 aa)
GYO_4408Gluconate operon transcriptional repressor. (243 aa)
gntKGluconate kinase; Belongs to the FGGY kinase family. (513 aa)
GYO_4410Gluconate permease. (448 aa)
GYO_44116-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
GYO_44186-phospho-beta-glucosidase; Belongs to the glycosyl hydrolase 1 family. (479 aa)
GYO_4419Pts system beta-glucoside-specific eiibca component. (622 aa)
fbpFirmicute fructose-1,6-bisphosphatase superfamily. (641 aa)
Your Current Organism:
Bacillus subtilis spizizenii
NCBI taxonomy Id: 1052585
Other names: B. subtilis subsp. spizizenii TU-B-10, Bacillus subtilis subsp. spizizenii TU-B-10, Bacillus subtilis subsp. spizizenii str. TU-B-10, Bacillus subtilis subsp. spizizenii strain TU-B-10
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