STRINGSTRING
citS citS GYO_0019 GYO_0019 GYO_0020 GYO_0020 tmk tmk ispE ispE prs prs GYO_0079 GYO_0079 coaX coaX folK folK mcsB mcsB adk adk GYO_0360 GYO_0360 GYO_0389 GYO_0389 GYO_0392 GYO_0392 ptsG ptsG GYO_0451 GYO_0451 ycbM ycbM natK natK aroK aroK GYO_0592 GYO_0592 yclM yclM GYO_0615 GYO_0615 GYO_0616 GYO_0616 GYO_0634 GYO_0634 dctS dctS GYO_0690 GYO_0690 rsbW rsbW yclK yclK ydfH ydfH GYO_0839 GYO_0839 GYO_0840 GYO_0840 GYO_0844 GYO_0844 thiL thiL GYO_0873 GYO_0873 GYO_0926 GYO_0926 GYO_0935 GYO_0935 GYO_0955 GYO_0955 GYO_1037 GYO_1037 treP treP GYO_1088 GYO_1088 yfiK yfiK prkA prkA GYO_1200 GYO_1200 glpK glpK GYO_1220 GYO_1220 yisZ yisZ argB argB GYO_1465 GYO_1465 nadK nadK GYO_1476 GYO_1476 GYO_1503 GYO_1503 GYO_1504 GYO_1504 proB proB GYO_1666 GYO_1666 kinE kinE mtnK mtnK kinD kinD GYO_1723 GYO_1723 ptsI ptsI kinA kinA pfkB pfkB kinC kinC cysC cysC gmk gmk yloP yloP GYO_1931 GYO_1931 GYO_1934 GYO_1934 cheA cheA pyrH pyrH ribF ribF GYO_2032 GYO_2032 xylB xylB proJ proJ GYO_2233 GYO_2233 GYO_2293 GYO_2293 GYO_2320 GYO_2320 GYO_2436 GYO_2436 GYO_2449 GYO_2449 ndk ndk cmk cmk resE resE spoIIAB spoIIAB coaA coaA GYO_2645 GYO_2645 buk buk GYO_2749 GYO_2749 GYO_2788 GYO_2788 GYO_2797 GYO_2797 GYO_2878 GYO_2878 GYO_2886 GYO_2886 GYO_2940 GYO_2940 GYO_2941 GYO_2941 GYO_2942 GYO_2942 udk udk GYO_3000 GYO_3000 GYO_3019 GYO_3019 spo0B spo0B lysC lysC araB araB lytS lytS coaE coaE phoR phoR pyk pyk pfkA pfkA ackA ackA nadK-2 nadK-2 GYO_3240 GYO_3240 GYO_3242 GYO_3242 bceS bceS rhaB rhaB kinB kinB GYO_3434 GYO_3434 malK malK comP comP thrB thrB GYO_3557 GYO_3557 cssS cssS liaS liaS GYO_3628 GYO_3628 GYO_3687 GYO_3687 pgk pgk GYO_3739 GYO_3739 yveL yveL epsA epsA yvcQ yvcQ hprK hprK GYO_3849 GYO_3849 GYO_3859 GYO_3859 degS degS rbsK rbsK GYO_3986 GYO_3986 GYO_3987 GYO_3987 GYO_4000 GYO_4000 tdk tdk GYO_4091 GYO_4091 thiD thiD GYO_4195 GYO_4195 galK galK thiM thiM GYO_4238 GYO_4238 GYO_4246 GYO_4246 GYO_4260 GYO_4260 GYO_4261 GYO_4261 yxijM yxijM GYO_4315 GYO_4315 GYO_4334 GYO_4334 yxdK yxdK iolC iolC GYO_4407 GYO_4407 gntK gntK GYO_4419 GYO_4419 GYO_4445 GYO_4445 yycG yycG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
citSSensory histidine kinase CitS. (528 aa)
GYO_0019Dck. (217 aa)
GYO_0020Dgk. (207 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (292 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa)
GYO_0079YabT. (338 aa)
coaXTranscriptional activator, Baf family protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (258 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (167 aa)
mcsBPutative ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. (363 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
GYO_0360YbbF. (455 aa)
GYO_0389Sensor histidine kinase, putative YbdK. (328 aa)
GYO_0392Protein kinase, putative YbdM. (256 aa)
ptsGPts system, glucose-specific iibc component. (631 aa)
GYO_0451YcbJ. (306 aa)
ycbMPutative sensor-like histidine kinase YcbM. (310 aa)
natKSensor-like histidine kinase. (318 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa)
GYO_0592YclK. (472 aa)
yclMPutative aspartokinase III; Belongs to the aspartokinase family. (454 aa)
GYO_0615Pts system mannitol-specific eiicba component. (477 aa)
GYO_0616Pts system mannitol-specific eiicba component. (143 aa)
GYO_0634HTH domain family. (696 aa)
dctSC4-dicarboxylate histidine kinase DctS. (535 aa)
GYO_0690Serine/threonine-protein kinase RsbT. (133 aa)
rsbWAnti-sigma B factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). (160 aa)
yclKTwo-component sensor histidine kinase YclK. (483 aa)
ydfHSensor histidine kinase YdfH. (387 aa)
GYO_0839Cellobiose-specific phosphotransferase enzyme IIB component. (103 aa)
GYO_0840Lichenan-specific phosphotransferase enzyme IIA component. (110 aa)
GYO_0844Fructokinase. (299 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa)
GYO_0873Fructokinase. (320 aa)
GYO_0926Phosphotransferase enzyme family, putative. (333 aa)
GYO_0935Conserved hypothetical protein. (303 aa)
GYO_0955Histidine kinase family protein. (577 aa)
GYO_1037PTS system N-acetylglucosamine-specific EIICBA component. (452 aa)
trePPts system, trehalose-specific iibc component. (470 aa)
GYO_1088Pts system maltose-specific eiicb component. (527 aa)
yfiKHistidine kinase YfiK. (388 aa)
prkASporulation serine protein kinase PrkA. (631 aa)
GYO_1200Ggdef domain protein. (359 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (496 aa)
GYO_1220Conserved hypothetical protein. (380 aa)
yisZSporulation putative adenylylsulfate kinase YisZ; Catalyzes the synthesis of activated sulfate. (199 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (258 aa)
GYO_1465YjbM. (212 aa)
nadKPutative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (266 aa)
GYO_1476Phosphomethylpyrimidine kinase. (271 aa)
GYO_1503HTH domain family. (648 aa)
GYO_1504Phosphotransferase system. (650 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (365 aa)
GYO_1666GGDEF domain protein. (728 aa)
kinESporulation sensor histidine kinase E. (738 aa)
mtnK5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (397 aa)
kinDSporulation sensor histidine kinase D. (500 aa)
GYO_1723PTS system glucose-specific EIICBA component. (699 aa)
ptsIPhosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (570 aa)
kinASporulation sensor histidine kinase A. (606 aa)
pfkB1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (303 aa)
kinCSporulation sensor histidine kinase C. (428 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (197 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
yloPPutative threonine/serine-protein kinase YloP. (648 aa)
GYO_1931Thiamine pyrophosphokinase. (214 aa)
GYO_1934Glycerone kinase protein. (553 aa)
cheAChemotaxis histidine kinase CheA. (671 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa)
ribFRiboflavin biosynthesis protein RibF; Belongs to the ribF family. (316 aa)
GYO_2032Aspartate kinase, monofunctional class; Belongs to the aspartokinase family. (404 aa)
xylBXylulokinase. (499 aa)
proJGlutamate 5-kinase 2; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (371 aa)
GYO_2233Carbohydrate kinase, FGGY family. (487 aa)
GYO_2293Fructokinase; Belongs to the carbohydrate kinase PfkB family. (333 aa)
GYO_2320Conserved hypothetical protein. (370 aa)
GYO_24362-dehydro-3-deoxygluconokinase. (324 aa)
GYO_2449Glucose-specific phosphotransferase enzyme IIA component. (168 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (148 aa)
cmkCytidylate kinase. (224 aa)
resESensor protein histidine kinase resE. (589 aa)
spoIIABAnti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa)
coaAPantothenate kinase. (319 aa)
GYO_2645Conserved hypothetical protein. (294 aa)
bukButyrate kinase; Belongs to the acetokinase family. (363 aa)
GYO_2749Glucokinase. (321 aa)
GYO_2788Protein YqfL; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (270 aa)
GYO_2797Diacylglycerol kinase. (123 aa)
GYO_2878Two-component sensor histidine kinase. (363 aa)
GYO_2886Pts system beta-glucoside-specific eiibca component. (617 aa)
GYO_2940Fructose-specific phosphotransferase enzyme IIB component. (162 aa)
GYO_2941Fructose-specific phosphotransferase enzyme IIA component. (146 aa)
GYO_2942Sigma-54 interaction domain family. (935 aa)
udkUridine kinase. (211 aa)
GYO_3000RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (734 aa)
GYO_3019YrzF. (175 aa)
spo0BSporulation initiation phosphotransferase Spo0B. (192 aa)
lysCAspartokinase II; Belongs to the aspartokinase family. (409 aa)
araBL-ribulokinase. (561 aa)
lytSSensor protein LytS. (593 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
phoRAlkaline phosphatase synthesis sensor protein PhoR. (579 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (558 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
nadK-2Putative inorganic polyphosphate/ATP-NAD kinase 2; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (267 aa)
GYO_3240YtmP. (265 aa)
GYO_3242Conserved hypothetical protein. (309 aa)
bceSSensor protein BceS. (334 aa)
rhaBRhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Belongs to the rhamnulokinase family. (486 aa)
kinBSporulation sensor histidine kinase B. (428 aa)
GYO_3434Kinase-associated lipoprotein B. (128 aa)
malKSensor protein MalK. (533 aa)
comPComP sensor histidine kinase. (770 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
GYO_3557Sugar kinase, ribokinase family. (284 aa)
cssSSensor protein CssS. (451 aa)
liaSSensor protein LiaS. (360 aa)
GYO_3628Conserved hypothetical protein. (573 aa)
GYO_3687Subtilin biosynthesis sensor protein SpaK. (421 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
GYO_3739Histidine kinase, putatice YvfU. (354 aa)
yveLExopolysaccharide biosynthesis YveL. (227 aa)
epsAExopolysaccharide biosynthesis EpsA. (234 aa)
yvcQTwo-component sensor histidine kinase. (356 aa)
hprKHPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...] (310 aa)
GYO_3849Conserved domain protein. (65 aa)
GYO_3859Pyruvate phosphate dikinase, PEP/pyruvate binding domain protein. (831 aa)
degSSensor protein DegS; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. (385 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (293 aa)
GYO_3986Capsular polysaccharide biosynthesis. (238 aa)
GYO_3987Capsular polysaccharide biosynthesis protein. (248 aa)
GYO_4000Two component sensor histidine kinase, putative YwpD. (1026 aa)
tdkThymidine kinase. (195 aa)
GYO_4091Sporulation initiation phosphotransferase F. (123 aa)
thiDPhosphomethylpyrimidine kinase. (232 aa)
GYO_4195PTS system sucrose-specific EIIBC component. (461 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (390 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (272 aa)
GYO_4238Pts system, sucrose-specific iibc component. (459 aa)
GYO_4246YwaC. (210 aa)
GYO_4260Lichenan-specific phosphotransferase enzyme IIB component. (102 aa)
GYO_4261HTH domain family. (641 aa)
yxijMPutative sensor-like histidine kinase protein YxjM. (406 aa)
GYO_4315Pts system beta-glucoside-specific eiibca component. (610 aa)
GYO_4334Pts system beta-glucoside-specific eiibca component. (612 aa)
yxdKSensor protein YxdK. (325 aa)
iolCProtein IolC; Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2- deoxy-D-gluconate (DKGP). (325 aa)
GYO_4407Glycerate kinase 2; Belongs to the glycerate kinase type-1 family. (382 aa)
gntKGluconate kinase; Belongs to the FGGY kinase family. (513 aa)
GYO_4419Pts system beta-glucoside-specific eiibca component. (622 aa)
GYO_4445Heavy metal sensor kinase. (483 aa)
yycGSensor protein YycG. (611 aa)
Your Current Organism:
Bacillus subtilis spizizenii
NCBI taxonomy Id: 1052585
Other names: B. subtilis subsp. spizizenii TU-B-10, Bacillus subtilis subsp. spizizenii TU-B-10, Bacillus subtilis subsp. spizizenii str. TU-B-10, Bacillus subtilis subsp. spizizenii strain TU-B-10
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