STRINGSTRING
GYO_4252 GYO_4252 GYO_4254 GYO_4254 cydB cydB GYO_4277 GYO_4277 GYO_4278 GYO_4278 GYO_4370 GYO_4370 GYO_4371 GYO_4371 yxdK yxdK yxdJ yxdJ GYO_4449 GYO_4449 yycG yycG GYO_4454 GYO_4454 dltC dltC dnaA dnaA GYO_0440 GYO_0440 glsA glsA glnL glnL GYO_0463 GYO_0463 natK natK natR natR GYO_0476 GYO_0476 GYO_0477 GYO_0477 GYO_0557 GYO_0557 dctS dctS dctR dctR dctA dctA GYO_0730 GYO_0730 yclJ yclJ ydfH ydfH ydfI ydfI GYO_0778 GYO_0778 phoB phoB GYO_0955 GYO_0955 yesM yesM citS citS citT citT GYO_1027 GYO_1027 GYO_1055 GYO_1055 mprF mprF GYO_1229 GYO_1229 GYO_1337 GYO_1337 GYO_1609 GYO_1609 kinE kinE kinD kinD GYO_1697 GYO_1697 GYO_1729 GYO_1729 kinA kinA GYO_1737 GYO_1737 kinC kinC glsA-2 glsA-2 ctaA ctaA cheY cheY cheB cheB cheA cheA GYO_1999 GYO_1999 GYO_2002 GYO_2002 glnA glnA GYO_2162 GYO_2162 GYO_2183 GYO_2183 GYO_2241 GYO_2241 GYO_2318 GYO_2318 GYO_2320 GYO_2320 GYO_2321 GYO_2321 GYO_2367 GYO_2367 GYO_2380 GYO_2380 GYO_2381 GYO_2381 cheR cheR resE resE resD resD GYO_2591 GYO_2591 mmgA mmgA spo0A spo0A pstS pstS GYO_2877 GYO_2877 GYO_2878 GYO_2878 spo0B spo0B GYO_3119 GYO_3119 lrgB lrgB lrgA lrgA lytT lytT lytS lytS phoR phoR phoP phoP GYO_3175 GYO_3175 GYO_3221 GYO_3221 GYO_3236 GYO_3236 GYO_3288 GYO_3288 GYO_3289 GYO_3289 bceS bceS bceR bceR GYO_3325 GYO_3325 GYO_3326 GYO_3326 GYO_3406 GYO_3406 GYO_3407 GYO_3407 GYO_3408 GYO_3408 GYO_3409 GYO_3409 kinB kinB GYO_3434 GYO_3434 malK malK malR malR GYO_3447 GYO_3447 comA comA comP comP comX comX GYO_3603 GYO_3603 cssR cssR cssS cssS liaR liaR liaS liaS GYO_3616 GYO_3616 GYO_3617 GYO_3617 GYO_3618 GYO_3618 GYO_3619 GYO_3619 GYO_3686 GYO_3686 GYO_3687 GYO_3687 GYO_3688 GYO_3688 GYO_3689 GYO_3689 GYO_3690 GYO_3690 GYO_3691 GYO_3691 GYO_3692 GYO_3692 GYO_3694 GYO_3694 GYO_3695 GYO_3695 GYO_3696 GYO_3696 GYO_3738 GYO_3738 GYO_3739 GYO_3739 rpoN rpoN GYO_3780 GYO_3780 GYO_3804 GYO_3804 hag2 hag2 hag1 hag1 csrA csrA flgM flgM degU degU degS degS mnaA mnaA GYO_3985 GYO_3985 GYO_3999 GYO_3999 GYO_4016 GYO_4016 GYO_4081 GYO_4081 GYO_4091 GYO_4091 narI narI narJ narJ narH narH GYO_4108 GYO_4108 dltA dltA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
GYO_4252Protein DltB; Could be involved in the transport of activated D-alanine through the membrane. (395 aa)
GYO_4254Protein DltD. (392 aa)
cydBCytochrome D ubiquinol oxidase, subunit II. (338 aa)
GYO_4277Cytochrome D ubiquinol oxidase subunit 1. (468 aa)
GYO_4278Citrate/malate transporter. (450 aa)
GYO_4370ABC transporter permease protein YxdM. (622 aa)
GYO_4371ABC transporter ATP-binding protein YxdL. (257 aa)
yxdKSensor protein YxdK. (325 aa)
yxdJSensory transduction protein YxdJ. (229 aa)
GYO_4449Putative serine protease YyxA. (401 aa)
yycGSensor protein YycG. (611 aa)
GYO_4454Transcriptional regulatory protein YycF. (235 aa)
dltCD-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (78 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (446 aa)
GYO_0440Amino acid carrier protein AlsT. (478 aa)
glsAGlutaminase 1; Belongs to the glutaminase family. (324 aa)
glnLSensory transduction protein GlnL. (314 aa)
GYO_0463Alkaline phosphatase D. (583 aa)
natKSensor-like histidine kinase. (318 aa)
natRDNA-binding response regulator. (233 aa)
GYO_0476ATP-binding transport protein NatA. (246 aa)
GYO_0477Protein NatB. (386 aa)
GYO_0557Methyl-accepting chemotaxis protein TlpC. (574 aa)
dctSC4-dicarboxylate histidine kinase DctS. (535 aa)
dctRC4-dicarboxylate response regulator DctR. (226 aa)
dctAAerobic C4-dicarboxylate transport protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (421 aa)
GYO_0730Delta5 acyl-lipid desaturase. (342 aa)
yclJTwo-component response regulator YclJ. (237 aa)
ydfHSensor histidine kinase YdfH. (387 aa)
ydfIResponse regulator YdfI. (213 aa)
GYO_0778Mmpl family. (723 aa)
phoBAlkaline phosphatase 3; Belongs to the alkaline phosphatase family. (462 aa)
GYO_0955Histidine kinase family protein. (577 aa)
yesMResponse regulator YesM. (368 aa)
citSSensory histidine kinase CitS. (528 aa)
citTResponse regulator CitT. (226 aa)
GYO_1027Mg(2+)/citrate complex secondary transporter. (433 aa)
GYO_1055YfkJ; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (156 aa)
mprFYfiX; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. (856 aa)
GYO_1229Alkaline phosphatase 4; Belongs to the alkaline phosphatase family. (458 aa)
GYO_1337acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (364 aa)
GYO_1609Trypsin domain protein. (453 aa)
kinESporulation sensor histidine kinase E. (738 aa)
kinDSporulation sensor histidine kinase D. (500 aa)
GYO_1697Chemotaxis protein motA. (270 aa)
GYO_1729Methyl-accepting chemotaxis protein McpC. (655 aa)
kinASporulation sensor histidine kinase A. (606 aa)
GYO_1737Chemotaxis protein cheV. (303 aa)
kinCSporulation sensor histidine kinase C. (428 aa)
glsA-2Glutaminase 2; Belongs to the glutaminase family. (309 aa)
ctaACytochrome aa3-controlling protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. (306 aa)
cheYChemotaxis response regulator CheY. (120 aa)
cheBProtein-glutamate methylesterase CheB; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (356 aa)
cheAChemotaxis histidine kinase CheA. (671 aa)
GYO_1999Chemotaxis protein cheW. (156 aa)
GYO_2002RNA polymerase sigma-D factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (254 aa)
glnAGlutamine synthetase. (444 aa)
GYO_2162Conserved hypothetical protein. (120 aa)
GYO_2183Endoglucanase. (499 aa)
GYO_2241YoaH. (561 aa)
GYO_2318Fatty acid desaturase. (352 aa)
GYO_2320Conserved hypothetical protein. (370 aa)
GYO_2321Conserved hypothetical protein. (199 aa)
GYO_2367YokZ. (273 aa)
GYO_23803-oxoadipate CoA-transferase subunit B. (217 aa)
GYO_2381Acetate CoA-transferase alpha subunit. (229 aa)
cheRCheR methyltransferase. (256 aa)
resESensor protein histidine kinase resE. (589 aa)
resDTranscriptional regulatory protein ResD. (240 aa)
GYO_2591Putative NAD-dependent malic enzyme 1. (439 aa)
mmgAacetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
spo0ASporulation transcriptional regulator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (267 aa)
pstSPstS. (300 aa)
GYO_2877Two component response regulator. (214 aa)
GYO_2878Two-component sensor histidine kinase. (363 aa)
spo0BSporulation initiation phosphotransferase Spo0B. (192 aa)
GYO_3119Hypothetical protein. (297 aa)
lrgBEffector of murein hydrolase; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. (231 aa)
lrgAMurein hydrolase regulator LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. (146 aa)
lytTSensory transduction protein LytT. (241 aa)
lytSSensor protein LytS. (593 aa)
phoRAlkaline phosphatase synthesis sensor protein PhoR. (579 aa)
phoPAlkaline phosphatase synthesis transcriptional regulatory protein PhoP. (240 aa)
GYO_3175YtsJ. (410 aa)
GYO_3221Chemotaxis protein PomA. (272 aa)
GYO_3236Putative NAD-dependent malic enzyme 3. (566 aa)
GYO_3288Bacitracin export permease protein BceB. (646 aa)
GYO_3289Bacitracin export ATP-binding protein BceA. (253 aa)
bceSSensor protein BceS. (334 aa)
bceRSensory transduction protein BceR. (231 aa)
GYO_3325YthA. (443 aa)
GYO_3326YthB. (346 aa)
GYO_3406Methyl-accepting chemotaxis protein TlpB. (662 aa)
GYO_3407Methyl-accepting chemotaxis protein McpA. (661 aa)
GYO_3408Methyl-accepting chemotaxis protein TlpA. (663 aa)
GYO_3409Methyl-accepting chemotaxis protein McpB. (662 aa)
kinBSporulation sensor histidine kinase B. (428 aa)
GYO_3434Kinase-associated lipoprotein B. (128 aa)
malKSensor protein MalK. (533 aa)
malRTranscriptional regulatory protein MalR. (235 aa)
GYO_3447Na(+)-malate symporter. (448 aa)
comACompetence protein A. (214 aa)
comPComP sensor histidine kinase. (770 aa)
comXComX pheromone precursor. (73 aa)
GYO_3603Putative serine protease do-like htrA. (458 aa)
cssRTranscriptional regulatory protein CssR. (225 aa)
cssSSensor protein CssS. (451 aa)
liaRSensory transduction protein LiaR. (211 aa)
liaSSensor protein LiaS. (360 aa)
GYO_3616Protein LiaF. (241 aa)
GYO_3617Protein LiaG. (290 aa)
GYO_3618Protein LiaH. (226 aa)
GYO_3619Protein LiaI. (126 aa)
GYO_3686Methyl-accepting chemotaxis protein. (566 aa)
GYO_3687Subtilin biosynthesis sensor protein SpaK. (421 aa)
GYO_3688Subtilin biosynthesis regulatory protein SpaR. (220 aa)
GYO_3689SpaG. (203 aa)
GYO_3690SpaE. (251 aa)
GYO_3691Bacitracin transport ATP-binding protein BcrA. (238 aa)
GYO_3692SpaI. (165 aa)
GYO_3694Subtilin biosynthesis protein SpaC. (441 aa)
GYO_3695Conserved hypothetical protein. (614 aa)
GYO_3696Putative subtilin biosynthesis protein SpaB. (1030 aa)
GYO_3738Conserved hypothetical protein. (200 aa)
GYO_3739Histidine kinase, putatice YvfU. (354 aa)
rpoNRNA polymerase sigma-54 factor. (436 aa)
GYO_3780Levansucrase; Belongs to the glycosyl hydrolase 68 family. (473 aa)
GYO_3804Bacitracin export ATP-binding protein BceA. (259 aa)
hag2Flagellin-2; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (274 aa)
hag1Flagellin-1; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (279 aa)
csrACarbon storage regulator; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (74 aa)
flgMAnti-sigma-28 factor, FlgM. (88 aa)
degUTranscriptional regulatory protein DegU. (229 aa)
degSSensor protein DegS; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. (385 aa)
mnaAUDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (380 aa)
GYO_3985Putative tyrosine-protein phosphatase CapC. (254 aa)
GYO_3999Two-component response regulator. (358 aa)
GYO_4016Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. (116 aa)
GYO_4081Putative NAD-dependent malic enzyme 3. (565 aa)
GYO_4091Sporulation initiation phosphotransferase F. (123 aa)
narIRespiratory nitrate reductase, gamma subunit. (223 aa)
narJNitrate reductase molybdenum cofactor assembly chaperone. (184 aa)
narHNitrate reductase, beta subunit. (487 aa)
GYO_4108Nitrate reductase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1228 aa)
dltAD-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] (504 aa)
Your Current Organism:
Bacillus subtilis spizizenii
NCBI taxonomy Id: 1052585
Other names: B. subtilis subsp. spizizenii TU-B-10, Bacillus subtilis subsp. spizizenii TU-B-10, Bacillus subtilis subsp. spizizenii str. TU-B-10, Bacillus subtilis subsp. spizizenii strain TU-B-10
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