(23 nodes) Lagging Strand Synthesis, and Checkpoint clamp complex network (Cavenderia fasciculata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	rad1	Exonuclease. (301 aa)
	rfc5	Replication factor C subunit. (368 aa)
	DFA_05409	AAA domain-containing protein. (1001 aa)
	repG	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa)
	DFA_05293	Uncharacterized protein. (76 aa)
	rad17	Uncharacterized protein rad17. (1444 aa)
	polD2	DNA polymerase delta subunit 2. (495 aa)
	DFA_01383	Vezatin domain-containing protein. (826 aa)
	wrn	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (926 aa)
	rfc1	Replication factor C subunit. (1578 aa)
	DFA_07573	UMUC-like DNA-repair protein. (454 aa)
	DFA_02183	Mitotic spindle assembly checkpoint protein MAD2B. (382 aa)
	DFA_02271	AAA_12 domain-containing protein. (1700 aa)
	rfc4	Replication factor C subunit. (358 aa)
	DFA_03823	BRCT domain-containing protein. (842 aa)
	rad9	Component of 9-1-1 complex. (525 aa)
	DFA_09013	Uncharacterized protein. (855 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (257 aa)
	rfc3	Replication factor C subunit. (352 aa)
	DFA_10336	Uncharacterized protein. (654 aa)
	rfc2	Replication factor C subunit. (325 aa)
	polZ	DNA polymerase zeta catalytic subunit. (2115 aa)
	polD1	DNA polymerase. (1801 aa)

Your Current Organism:

Cavenderia fasciculata

NCBI taxonomy Id: 1054147
Other names: C. fasciculata SH3, Cavenderia fasciculata SH3, Dictyostelium fasciculatum SH3, Dictyostelium fasciculatum strain SH3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DFA_01383	DFA_02183	F4PSG7	F4PYC9	Vezatin domain-containing protein.	Mitotic spindle assembly checkpoint protein MAD2B.	0.761
DFA_01383	DFA_02271	F4PSG7	F4PYZ9	Vezatin domain-containing protein.	AAA_12 domain-containing protein.	0.564
DFA_01383	DFA_03823	F4PSG7	F4Q0H8	Vezatin domain-containing protein.	BRCT domain-containing protein.	0.850
DFA_01383	DFA_05293	F4PSG7	F4PNV8	Vezatin domain-containing protein.	Uncharacterized protein.	0.940
DFA_01383	DFA_05409	F4PSG7	F4PL55	Vezatin domain-containing protein.	AAA domain-containing protein.	0.850
DFA_01383	DFA_07573	F4PSG7	F4PWT5	Vezatin domain-containing protein.	UMUC-like DNA-repair protein.	0.967
DFA_01383	DFA_09013	F4PSG7	F4Q6G5	Vezatin domain-containing protein.	Uncharacterized protein.	0.924
DFA_01383	DFA_10336	F4PSG7	F4Q9X7	Vezatin domain-containing protein.	Uncharacterized protein.	0.490
DFA_01383	polD1	F4PSG7	F4QFP5	Vezatin domain-containing protein.	DNA polymerase.	0.970
DFA_01383	polD2	F4PSG7	F4PRP8	Vezatin domain-containing protein.	DNA polymerase delta subunit 2.	0.969
DFA_01383	polZ	F4PSG7	F4QBX1	Vezatin domain-containing protein.	DNA polymerase zeta catalytic subunit.	0.903
DFA_01383	rad17	F4PSG7	F4PRL6	Vezatin domain-containing protein.	Uncharacterized protein rad17.	0.789
DFA_01383	repG	F4PSG7	F4PNV7	Vezatin domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.940
DFA_01383	rfc1	F4PSG7	F4PUN1	Vezatin domain-containing protein.	Replication factor C subunit.	0.850
DFA_01383	rfc2	F4PSG7	F4QBL9	Vezatin domain-containing protein.	Replication factor C subunit.	0.976
DFA_01383	rfc3	F4PSG7	F4Q8U6	Vezatin domain-containing protein.	Replication factor C subunit.	0.980
DFA_01383	rfc4	F4PSG7	F4PZ01	Vezatin domain-containing protein.	Replication factor C subunit.	0.988
DFA_01383	rfc5	F4PSG7	F4PL06	Vezatin domain-containing protein.	Replication factor C subunit.	0.966
DFA_01383	wrn	F4PSG7	F4PT39	Vezatin domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.997
DFA_02183	DFA_01383	F4PYC9	F4PSG7	Mitotic spindle assembly checkpoint protein MAD2B.	Vezatin domain-containing protein.	0.761