(10 nodes) Mitotic DNA damage checkpoint signaling network (Cavenderia fasciculata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (715 aa)
	fhkC	Protein kinase 1. (504 aa)
	DFA_04403	Uncharacterized protein. (1857 aa)
	DFA_00375	U1-type domain-containing protein. (339 aa)
	DFA_00399	SWIM-type domain-containing protein. (989 aa)
	mus81	Crossover junction endonuclease. (912 aa)
	fhkD	Uncharacterized protein fhkD. (1322 aa)
	DFA_02677	Uncharacterized protein. (466 aa)
	rad9	Component of 9-1-1 complex. (525 aa)
	cut5	BRCT domain-containing protein. (1243 aa)

Your Current Organism:

Cavenderia fasciculata

NCBI taxonomy Id: 1054147
Other names: C. fasciculata SH3, Cavenderia fasciculata SH3, Dictyostelium fasciculatum SH3, Dictyostelium fasciculatum strain SH3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DFA_00399	DFA_04403	F4PRN9	F4PPH2	SWIM-type domain-containing protein.	Uncharacterized protein.	0.628
DFA_00399	fhkC	F4PRN9	F4Q918	SWIM-type domain-containing protein.	Protein kinase 1.	0.444
DFA_00399	fhkD	F4PRN9	F4PVX0	SWIM-type domain-containing protein.	Uncharacterized protein fhkD.	0.444
DFA_00399	mre11	F4PRN9	F4QBF7	SWIM-type domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.639
DFA_00399	mus81	F4PRN9	F4PRR2	SWIM-type domain-containing protein.	Crossover junction endonuclease.	0.900
DFA_00399	rad9	F4PRN9	F4Q4Z7	SWIM-type domain-containing protein.	Component of 9-1-1 complex.	0.403
DFA_04403	DFA_00399	F4PPH2	F4PRN9	Uncharacterized protein.	SWIM-type domain-containing protein.	0.628
DFA_04403	cut5	F4PPH2	F4Q6J7	Uncharacterized protein.	BRCT domain-containing protein.	0.429
DFA_04403	mre11	F4PPH2	F4QBF7	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.452
DFA_04403	mus81	F4PPH2	F4PRR2	Uncharacterized protein.	Crossover junction endonuclease.	0.628
cut5	DFA_04403	F4Q6J7	F4PPH2	BRCT domain-containing protein.	Uncharacterized protein.	0.429
cut5	mre11	F4Q6J7	F4QBF7	BRCT domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.602
cut5	rad9	F4Q6J7	F4Q4Z7	BRCT domain-containing protein.	Component of 9-1-1 complex.	0.922
fhkC	DFA_00399	F4Q918	F4PRN9	Protein kinase 1.	SWIM-type domain-containing protein.	0.444
fhkC	mre11	F4Q918	F4QBF7	Protein kinase 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.469
fhkC	mus81	F4Q918	F4PRR2	Protein kinase 1.	Crossover junction endonuclease.	0.444
fhkC	rad9	F4Q918	F4Q4Z7	Protein kinase 1.	Component of 9-1-1 complex.	0.459
fhkD	DFA_00399	F4PVX0	F4PRN9	Uncharacterized protein fhkD.	SWIM-type domain-containing protein.	0.444
fhkD	mre11	F4PVX0	F4QBF7	Uncharacterized protein fhkD.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.469
fhkD	mus81	F4PVX0	F4PRR2	Uncharacterized protein fhkD.	Crossover junction endonuclease.	0.444