STRINGSTRING
AGI47041.1 AGI47041.1 AGI47140.1 AGI47140.1 proC proC AGI47399.1 AGI47399.1 aroC aroC AGI47542.1 AGI47542.1 hisI hisI hisF hisF hisB hisB AGI47547.1 AGI47547.1 AGI47548.1 AGI47548.1 hisG hisG hisC hisC hisH hisH hisA hisA aroE aroE aroK aroK aroA-2 aroA-2 AGI47571.1 AGI47571.1 thrB thrB AGI47598.1 AGI47598.1 argH argH argG argG argC argC argJ argJ argB argB AGI47631.1 AGI47631.1 metAA metAA hisD hisD trpF trpF dapB dapB AGI48243.1 AGI48243.1 dapA dapA AGI48377.1 AGI48377.1 lysA lysA dapF dapF AGI48380.1 AGI48380.1 AGI48411.1 AGI48411.1 AGI48412.1 AGI48412.1 trpD trpD AGI48414.1 AGI48414.1 trpF-2 trpF-2 trpB trpB trpA trpA proB proB proA proA AGI48472.1 AGI48472.1 AGI48539.1 AGI48539.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AGI47041.1Pyridoxal-phosphate dependent TrpB-like enzyme. (442 aa)
AGI47140.1Prephenate dehydrogenase. (365 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (280 aa)
AGI47399.1Chorismate mutase. (97 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (353 aa)
AGI47542.1Histidinol phosphatase and related hydrolases of the PHP family. (215 aa)
hisIphosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisBImidazoleglycerol-phosphate dehydratase. (182 aa)
AGI47547.1Chorismate mutase. (100 aa)
AGI47548.1Aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms). (354 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa)
hisCHistidinol-phosphate aminotransferase. (354 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (237 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (433 aa)
aroKShikimate kinase. (270 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (421 aa)
AGI47571.1Prephenate dehydratase. (189 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)
AGI47598.1L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (414 aa)
argHArgininosuccinate lyase. (482 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (425 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase, common form; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa)
argJGlutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (274 aa)
AGI47631.1Acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (394 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (433 aa)
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (203 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (266 aa)
AGI48243.1Homoserine dehydrogenase. (339 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
AGI48377.1Aspartate kinase; Belongs to the aspartokinase family. (453 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (281 aa)
AGI48380.1Aspartate/tyrosine/aromatic aminotransferase. (387 aa)
AGI48411.1Anthranilate synthase, component I. (487 aa)
AGI48412.1Anthranilate synthase, component II. (196 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa)
AGI48414.1Indole-3-glycerol phosphate synthase. (263 aa)
trpF-2Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (199 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (434 aa)
AGI48472.1Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like protein. (221 aa)
AGI48539.1Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (408 aa)
Your Current Organism:
Thermoplasmatales archaeon BRNA1
NCBI taxonomy Id: 1054217
Other names: T. archaeon BRNA1
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