STRINGSTRING
polB polB AGI47064.1 AGI47064.1 AGI47065.1 AGI47065.1 AGI47066.1 AGI47066.1 AGI47067.1 AGI47067.1 AGI47069.1 AGI47069.1 AGI47076.1 AGI47076.1 AGI47077.1 AGI47077.1 AGI47085.1 AGI47085.1 AGI47087.1 AGI47087.1 AGI47098.1 AGI47098.1 AGI47122.1 AGI47122.1 ndk ndk tmk tmk AGI47159.1 AGI47159.1 AGI47161.1 AGI47161.1 AGI47167.1 AGI47167.1 rpoK rpoK AGI47195.1 AGI47195.1 kptA kptA carS carS cca cca AGI47333.1 AGI47333.1 AGI47426.1 AGI47426.1 AGI47432.1 AGI47432.1 polC polC AGI47439.1 AGI47439.1 AGI47477.1 AGI47477.1 AGI47504.1 AGI47504.1 AGI47506.1 AGI47506.1 AGI47527.1 AGI47527.1 aroK aroK AGI47583.1 AGI47583.1 AGI47590.1 AGI47590.1 AGI47591.1 AGI47591.1 thrB thrB AGI47603.1 AGI47603.1 thiM thiM AGI47623.1 AGI47623.1 argB argB dnaG dnaG AGI47699.1 AGI47699.1 dbh dbh ppk ppk AGI47753.1 AGI47753.1 AGI47758.1 AGI47758.1 AGI47759.1 AGI47759.1 AGI47781.1 AGI47781.1 AGI47788.1 AGI47788.1 AGI47799.1 AGI47799.1 mptE mptE AGI48110.1 AGI48110.1 cobS cobS AGI48136.1 AGI48136.1 AGI48142.1 AGI48142.1 AGI48157.1 AGI48157.1 adk adk AGI48283.1 AGI48283.1 cmk cmk AGI48339.1 AGI48339.1 AGI48343.1 AGI48343.1 rpoN rpoN thiL thiL AGI48377.1 AGI48377.1 pgk pgk AGI48401.1 AGI48401.1 AGI48409.1 AGI48409.1 AGI48420.1 AGI48420.1 nadK nadK proB proB priS priS rpoA2 rpoA2 AGI48491.1 AGI48491.1 AGI48492.1 AGI48492.1 rpoH rpoH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
polBArchaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (480 aa)
AGI47064.1Sugar kinase, ribokinase family. (302 aa)
AGI47065.1Putative nucleotide kinase (CMP and AMP kinases -like protein); Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (177 aa)
AGI47066.1Phosphatidylglycerophosphate synthase. (221 aa)
AGI47067.1Eukaryotic-type DNA primase, large subunit. (83 aa)
AGI47069.1Eukaryotic-type DNA primase, large subunit. (244 aa)
AGI47076.1Mannose-1-phosphate guanylyltransferase; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (343 aa)
AGI47077.1Putative kinase (galactokinase and mevalonate kinase -like protein). (342 aa)
AGI47085.1Hypothetical protein. (251 aa)
AGI47087.14-diphosphocytidyl-2-methyl-D-erithritol synthase. (240 aa)
AGI47098.1Phosphoenolpyruvate phosphomutase. (431 aa)
AGI47122.1Glucose-1-phosphate cytidylyltransferase. (257 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (153 aa)
tmkThymidylate kinase. (198 aa)
AGI47159.1Putative archaeal kinase (sugar kinase superfamily). (288 aa)
AGI47161.1Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (281 aa)
AGI47167.1Transcriptional regulator of a riboflavin/FAD biosynthetic operon. (229 aa)
rpoKDNA-directed RNA polymerase, subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (61 aa)
AGI47195.1Thiamine biosynthesis ATP pyrophosphatase. (208 aa)
kptARNA:NAD 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (216 aa)
carSCDP-diglyceride synthetase; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (190 aa)
ccaCCA-adding enzyme; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (442 aa)
AGI47333.1Hypothetical protein. (44 aa)
AGI47426.1Sua5/YciO/YrdC/YwlC family protein. (212 aa)
AGI47432.1DNA-directed RNA polymerase, alpha subunit/40 kD subunit. (287 aa)
polCDNA polymerase, archaeal type II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1128 aa)
AGI47439.1Mevalonate kinase. (326 aa)
AGI47477.1Putative membrane protein. (219 aa)
AGI47504.1DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form. (190 aa)
AGI47506.1Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (168 aa)
AGI47527.1Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (301 aa)
aroKShikimate kinase. (270 aa)
AGI47583.1Glucose-1-phosphate thymidylyltransferase. (290 aa)
AGI47590.1Hypothetical protein. (225 aa)
AGI47591.1Hypothetical protein. (217 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)
AGI47603.1Nicotinamide-nucleotide adenylyltransferase. (177 aa)
thiMHydroxyethylthiazole kinase, sugar kinase family; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (260 aa)
AGI47623.1Phosphomethylpyrimidine kinase. (432 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (274 aa)
dnaGDNA primase (bacterial type); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (570 aa)
AGI47699.1Cytidyltransferase-related domain protein. (140 aa)
dbhNucleotidyltransferase/DNA polymerase involved in DNA repair; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (427 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). (696 aa)
AGI47753.1Phosphoenolpyruvate synthase/pyruvate phosphate dikinase. (872 aa)
AGI47758.1Dolichol kinase. (232 aa)
AGI47759.1Thymidylate kinase. (190 aa)
AGI47781.1Pyridoxal/pyridoxine/pyridoxamine kinase. (282 aa)
AGI47788.1CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (180 aa)
AGI47799.1Hypothetical protein. (216 aa)
mptEPutative Rossmann fold enzyme; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (221 aa)
AGI48110.1GTP:adenosylcobinamide-phosphate guanylyltransferase. (198 aa)
cobSCobalamin 5'-phosphate synthase/cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (312 aa)
AGI48136.1DNA-directed RNA polymerase, subunit L. (81 aa)
AGI48142.1Putative membrane protein. (298 aa)
AGI48157.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (780 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (207 aa)
AGI48283.1Putative uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (229 aa)
cmkPutative rRNA pseudouridine synthase, putative/cytidylate kinase; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (503 aa)
AGI48339.1Putative archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (259 aa)
AGI48343.1Mn2+-dependent serine/threonine protein kinase. (211 aa)
rpoNDNA-directed RNA polymerase, subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (63 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (316 aa)
AGI48377.1Aspartate kinase; Belongs to the aspartokinase family. (453 aa)
pgk3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
AGI48401.1Serine/threonine protein kinase involved in cell cycle control. (279 aa)
AGI48409.1DNA polymerase elongation subunit (family B). (825 aa)
AGI48420.1Thiamine biosynthesis ATP pyrophosphatase. (285 aa)
nadKPutative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (533 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa)
priSPutative DNA primase, eukaryotic-type, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extensi [...] (422 aa)
rpoA2DNA-directed RNA polymerase, beta' subunit/160 kD subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (494 aa)
AGI48491.1DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (951 aa)
AGI48492.1DNA-directed RNA polymerase, subunit B'; Belongs to the RNA polymerase beta chain family. (1207 aa)
rpoHDNA-directed RNA polymerase, subunit H, RpoH/RPB5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (89 aa)
Your Current Organism:
Thermoplasmatales archaeon BRNA1
NCBI taxonomy Id: 1054217
Other names: T. archaeon BRNA1
Server load: low (24%) [HD]