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AGI47017.1 AGI47017.1 spt5 spt5 rpl11 rpl11 AGI47057.1 AGI47057.1 rpl10 rpl10 rpl12 rpl12 AGI47073.1 AGI47073.1 rpl7ae rpl7ae rps28e rps28e rpl24e rpl24e infB infB rps6e rps6e eif2g eif2g AGI47158.1 AGI47158.1 proS proS AGI47173.1 AGI47173.1 rps2 rps2 AGI47244.1 AGI47244.1 AGI47258.1 AGI47258.1 AGI47261.1 AGI47261.1 AGI47304.1 AGI47304.1 rps27e rps27e rpl44e rpl44e AGI47329.1 AGI47329.1 rpl37ae rpl37ae rps8e rps8e AGI47360.1 AGI47360.1 eif2b eif2b rps12 rps12 rps7 rps7 AGI47394.1 AGI47394.1 tuf tuf rps10 rps10 AGI47421.1 AGI47421.1 rps13 rps13 rps4 rps4 rps11 rps11 AGI47439.1 AGI47439.1 serS serS AGI47448.1 AGI47448.1 AGI47462.1 AGI47462.1 AGI47498.1 AGI47498.1 rps24e rps24e rps27ae rps27ae AGI47515.1 AGI47515.1 AGI47524.1 AGI47524.1 rpl40e rpl40e AGI47566.1 AGI47566.1 AGI47619.1 AGI47619.1 AGI47655.1 AGI47655.1 metG metG AGI47659.1 AGI47659.1 aspS aspS gltX gltX cysS cysS eif6 eif6 rpl31e rpl31e rpl39e rpl39e rps19e rps19e pheT pheT AGI47954.1 AGI47954.1 AGI47959.1 AGI47959.1 AGI47978.1 AGI47978.1 AGI48024.1 AGI48024.1 AGI48068.1 AGI48068.1 AGI48070.1 AGI48070.1 AGI48079.1 AGI48079.1 AGI48080.1 AGI48080.1 AGI48081.1 AGI48081.1 AGI48155.1 AGI48155.1 AGI48156.1 AGI48156.1 panD panD thrS thrS hisS hisS AGI48200.1 AGI48200.1 lysS lysS rpl37e rpl37e rps3ae rps3ae argS argS prf1 prf1 AGI48286.1 AGI48286.1 trpS trpS rpl15 rpl15 rpl30 rpl30 AGI48296.1 AGI48296.1 rpl18 rpl18 rpl19e rpl19e rpl32e rpl32e rpl6 rpl6 rps8 rps8 rps14 rps14 rpl5 rpl5 rps4e rps4e rpl24 rpl24 rpl14 rpl14 rps17 rps17 AGI48309.1 AGI48309.1 rpl29 rpl29 rps3 rps3 rpl22 rpl22 rps19p rps19p AGI48314.1 AGI48314.1 rpl23 rpl23 rpl4 rpl4 AGI48317.1 AGI48317.1 AGI48329.1 AGI48329.1 AGI48330.1 AGI48330.1 gatB gatB aspS-2 aspS-2 AGI48334.1 AGI48334.1 rps9 rps9 rpl13 rpl13 rpl18e rpl18e eif1a eif1a rpl21e rpl21e AGI48418.1 AGI48418.1 AGI48430.1 AGI48430.1 AGI48467.1 AGI48467.1 rps17e rps17e AGI48473.1 AGI48473.1 gatE gatE AGI48478.1 AGI48478.1 AGI48479.1 AGI48479.1 AGI48489.1 AGI48489.1 rpl18a rpl18a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGI47017.1Signal peptidase I. (269 aa)
spt5Ribosomal protein L24p/L26e, archaeal; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (274 aa)
rpl11LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (150 aa)
AGI47057.1LSU ribosomal protein L1P; Belongs to the universal ribosomal protein uL1 family. (185 aa)
rpl10Ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (334 aa)
rpl12LSU ribosomal protein L12AE; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (108 aa)
AGI47073.1Translation elongation factor EF-1beta. (89 aa)
rpl7aeLSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (121 aa)
rps28eSSU ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (71 aa)
rpl24eLSU ribosomal protein L24E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL24 family. (79 aa)
infBTranslation initiation factor aIF-2/yIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (582 aa)
rps6eSSU ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. (133 aa)
eif2gTranslation initiation factor 2 subunit gamma (aeIF-2g); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (412 aa)
AGI47158.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic. (396 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (469 aa)
AGI47173.1Hypothetical protein. (342 aa)
rps2SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (208 aa)
AGI47244.1Hypothetical protein. (163 aa)
AGI47258.1Translation initiation factor 5A (eIF-5A). (129 aa)
AGI47261.1Translation initiation factor 2B subunit I family (IF-2BI); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (333 aa)
AGI47304.1Translation initiation factor 2, alpha subunit (eIF-2alpha). (260 aa)
rps27eSSU ribosomal protein S27E. (55 aa)
rpl44eLSU ribosomal protein L44E; Binds to the 23S rRNA. (92 aa)
AGI47329.1tyrosyl-tRNA synthetase. (380 aa)
rpl37aeLSU ribosomal protein L37AE; Binds to the 23S rRNA. (92 aa)
rps8eSSU ribosomal protein S8E. (128 aa)
AGI47360.1Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (550 aa)
eif2bPutative translation initiation factor aIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (208 aa)
rps12SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (132 aa)
rps7SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (213 aa)
AGI47394.1Translation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (735 aa)
tufTranslation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (418 aa)
rps10SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (105 aa)
AGI47421.1alanyl-tRNA synthetase. (590 aa)
rps13Archaeal ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (178 aa)
rps4SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (220 aa)
rps11SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (124 aa)
AGI47439.1Mevalonate kinase. (326 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa)
AGI47448.1LSU ribosomal protein L10AE. (151 aa)
AGI47462.1Putative RNA-binding protein (contains PUA domain). (163 aa)
AGI47498.1Biotin synthase-related enzyme. (355 aa)
rps24eRibosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (103 aa)
rps27aeSSU ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (57 aa)
AGI47515.1isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (970 aa)
AGI47524.1Hypothetical protein. (194 aa)
rpl40eLSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa)
AGI47566.1Tyrosine lyase ThiH. (383 aa)
AGI47619.1Conserved hypothetical protein TIGR00283. (125 aa)
AGI47655.1Putative ATPase, RNase L inhibitor (RLI). (596 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (773 aa)
AGI47659.1EMAP domain protein. (193 aa)
aspSaspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). (436 aa)
gltXglutamyl-tRNA synthetase, archaeal and eukaryotic family; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (557 aa)
cysScysteinyl-tRNA synthetase. (474 aa)
eif6Putative translation initiation factor eIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (218 aa)
rpl31eLSU ribosomal protein L31E; Belongs to the ribosomal protein L31e family. (87 aa)
rpl39eLSU ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (53 aa)
rps19eSSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (143 aa)
pheTphenylalanyl-tRNA synthetase, beta subunit. (552 aa)
AGI47954.1Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit. (198 aa)
AGI47959.1leucyl-tRNA synthetase, archaeal and cytosolic family; Belongs to the class-I aminoacyl-tRNA synthetase family. (969 aa)
AGI47978.1Selenocysteine-specific translation elongation factor. (316 aa)
AGI48024.1Uncharacterized protein, possibly involved in aromatic compounds catabolism. (121 aa)
AGI48068.1glycyl-tRNA synthetase, dimeric type. (570 aa)
AGI48070.1valyl-tRNA synthetase. (873 aa)
AGI48079.1Hypothetical protein. (278 aa)
AGI48080.1Carbamoylphosphate synthase large subunit. (381 aa)
AGI48081.1Seryl-tRNA synthetase. (273 aa)
AGI48155.12-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (94 aa)
AGI48156.12-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family. (185 aa)
panDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (112 aa)
thrSthreonyl-tRNA synthetase/Ser-tRNA(Thr) hydrolase; Belongs to the class-II aminoacyl-tRNA synthetase family. (581 aa)
hisShistidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (416 aa)
AGI48200.1Small GTP-binding protein domain protein. (370 aa)
lysSlysyl-tRNA synthetase, archaeal and spirochete; Belongs to the class-I aminoacyl-tRNA synthetase family. (516 aa)
rpl37eLSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (56 aa)
rps3aeRibosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (238 aa)
argSarginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (589 aa)
prf1Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (411 aa)
AGI48286.1phenylalanyl-tRNA synthetase, alpha subunit. (509 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). (373 aa)
rpl15Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (140 aa)
rpl30LSU ribosomal protein L30P. (157 aa)
AGI48296.1SSU ribosomal protein S5P; Belongs to the universal ribosomal protein uS5 family. (213 aa)
rpl18LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (166 aa)
rpl19eLSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (153 aa)
rpl32eRibosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (224 aa)
rpl6LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (185 aa)
rps8SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (129 aa)
rps14SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (48 aa)
rpl5LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (174 aa)
rps4eRibosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (234 aa)
rpl24Ribosomal protein L24p/L26e, archaeal/eukaryotic; Located at the polypeptide exit tunnel on the outside of the subunit. (123 aa)
rpl14LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
rps17SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (112 aa)
AGI48309.1Translation initiation factor 1 (eIF-1/SUI1); Belongs to the SUI1 family. (99 aa)
rpl29LSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (69 aa)
rps3SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (227 aa)
rpl22Ribosomal protein L22(archaeal)/L17(eukaryotic/archaeal); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (151 aa)
rps19pSSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (155 aa)
AGI48314.1LSU ribosomal protein L2P. (208 aa)
rpl23Ribosomal protein L23; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (93 aa)
rpl450S ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (258 aa)
AGI48317.1Archaeal ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (283 aa)
AGI48329.1glutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, C subunit. (90 aa)
AGI48330.1Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit-related amidase. (442 aa)
gatBglutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (450 aa)
aspS-2aspartyl-tRNA synthetase, bacterial type; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (606 aa)
AGI48334.1Alanyl-tRNA synthetase. (393 aa)
rps9SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rpl13Ribosomal protein L13, archaeal/eukaryotic; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (141 aa)
rpl18eLSU ribosomal protein L18AE; Belongs to the eukaryotic ribosomal protein eL18 family. (122 aa)
eif1aTranslation initiation factor 1A (aeIF-1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (108 aa)
rpl21eLSU ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (97 aa)
AGI48418.1LSU ribosomal protein L15E. (208 aa)
AGI48430.1SSU ribosomal protein S15P; Belongs to the universal ribosomal protein uS15 family. (134 aa)
AGI48467.1Putative RNA-binding protein, eukaryotic snRNP -like protein. (649 aa)
rps17eSSU ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (63 aa)
AGI48473.1Putative archaeal Zn-finger protein. (223 aa)
gatEglutamyl-tRNA(Gln) amidotransferase, subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (624 aa)
AGI48478.1L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D. (118 aa)
AGI48479.1L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D. (302 aa)
AGI48489.1Ribosomal protein L30E. (94 aa)
rpl18aRibosomal protein L20A (L18A). (74 aa)
Your Current Organism:
Thermoplasmatales archaeon BRNA1
NCBI taxonomy Id: 1054217
Other names: T. archaeon BRNA1
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