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atpE atpE atpC atpC atpF atpF atpA atpA atpB atpB atpD atpD purE purE guaAB guaAB guaAA guaAA AGI47092.1 AGI47092.1 ndk ndk AGI47158.1 AGI47158.1 AGI47159.1 AGI47159.1 purS purS purL purL purQ purQ AGI47188.1 AGI47188.1 AGI47199.1 AGI47199.1 AGI47214.1 AGI47214.1 AGI47215.1 AGI47215.1 folD folD AGI47265.1 AGI47265.1 AGI47276.1 AGI47276.1 AGI47328.1 AGI47328.1 AGI47360.1 AGI47360.1 AGI47439.1 AGI47439.1 AGI47463.1 AGI47463.1 AGI47506.1 AGI47506.1 eno eno AGI47533.1 AGI47533.1 mtnP mtnP purC purC tpiA tpiA purA purA AGI47894.1 AGI47894.1 AGI47905.1 AGI47905.1 AGI47916.1 AGI47916.1 AGI47937.1 AGI47937.1 AGI47938.1 AGI47938.1 AGI47954.1 AGI47954.1 AGI47996.1 AGI47996.1 AGI48155.1 AGI48155.1 AGI48156.1 AGI48156.1 purF purF adk adk AGI48277.1 AGI48277.1 pgk pgk gap gap AGI48396.1 AGI48396.1 apt apt purD purD purM purM
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
atpEArchaeal/vacuolar-type H+-ATPase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (185 aa)
atpCATP synthase A1, C subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (350 aa)
atpFArchaeal/vacuolar-type H+-ATPase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (101 aa)
atpAArchaeal/vacuolar-type H+-ATPase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (553 aa)
atpBArchaeal/vacuolar-type H+-ATPase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (460 aa)
atpDH(+)-transporting ATP synthase, vacuolar type, subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (212 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa)
guaABGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (320 aa)
guaAAGMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit; Catalyzes the synthesis of GMP from XMP. (191 aa)
AGI47092.1Archaeal conserved hypothetical protein. (249 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (153 aa)
AGI47158.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic. (396 aa)
AGI47159.1Putative archaeal kinase (sugar kinase superfamily). (288 aa)
purSPhosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (80 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (778 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (272 aa)
AGI47188.1ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases). (357 aa)
AGI47199.1IMP cyclohydrolase. (542 aa)
AGI47214.1Ribulose 1,5-bisphosphate carboxylase, large subunit. (412 aa)
AGI47215.1Putative thymidine phosphorylase/AMP phosphorylase. (504 aa)
folDMethenyltetrahydrofolate cyclohydrolase/5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
AGI47265.1NAD-dependent aldehyde dehydrogenase. (461 aa)
AGI47276.1NCAIR mutase (PurE)-related protein. (250 aa)
AGI47328.1Adenine/guanine phosphoribosyltransferase-related PRPP-binding protein. (190 aa)
AGI47360.1Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (550 aa)
AGI47439.1Mevalonate kinase. (326 aa)
AGI47463.1HD superfamily phosphohydrolase. (441 aa)
AGI47506.1Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (168 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
AGI47533.1Putative phosphoglycerate mutase, AP superfamily. (334 aa)
mtnPMethylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (264 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (300 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (225 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (434 aa)
AGI47894.1Putative methanogenesis marker protein 2. (336 aa)
AGI47905.13-hydroxy-3-methylglutaryl-coenzyme A reductase. (391 aa)
AGI47916.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (440 aa)
AGI47937.1Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (108 aa)
AGI47938.1Hypothetical protein. (73 aa)
AGI47954.1Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit. (198 aa)
AGI47996.1GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit. (326 aa)
AGI48155.12-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (94 aa)
AGI48156.12-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family. (185 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (207 aa)
AGI48277.1ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases). (391 aa)
pgk3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase. (337 aa)
AGI48396.1Folate-dependent phosphoribosylglycinamide formyltransferase PurN. (272 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (441 aa)
purMPhosphoribosylaminoimidazole synthetase. (338 aa)
Your Current Organism:
Thermoplasmatales archaeon BRNA1
NCBI taxonomy Id: 1054217
Other names: T. archaeon BRNA1
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