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AGI48531.1 AGI48531.1 AGI47115.1 AGI47115.1 AGI47173.1 AGI47173.1 AGI47202.1 AGI47202.1 AGI47209.1 AGI47209.1 AGI47266.1 AGI47266.1 AGI47422.1 AGI47422.1 AGI47436.1 AGI47436.1 AGI47444.1 AGI47444.1 queE queE AGI47498.1 AGI47498.1 AGI47519.1 AGI47519.1 AGI47529.1 AGI47529.1 hisF hisF hisA hisA AGI47557.1 AGI47557.1 aroA aroA aroE aroE AGI47565.1 AGI47565.1 AGI47566.1 AGI47566.1 AGI47567.1 AGI47567.1 AGI47614.1 AGI47614.1 thiE thiE AGI47645.1 AGI47645.1 aroA-3 aroA-3 tpiA tpiA AGI47797.1 AGI47797.1 taw1 taw1 trpF trpF pyrD pyrD AGI48015.1 AGI48015.1 AGI48195.1 AGI48195.1 fni fni AGI48372.1 AGI48372.1 dapA dapA AGI48410.1 AGI48410.1 AGI48414.1 AGI48414.1 trpF-2 trpF-2 trpA trpA pdxS pdxS pyrF pyrF AGI48487.1 AGI48487.1 AGI48495.1 AGI48495.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGI48531.13-hexulose-6-phosphate synthase. (430 aa)
AGI47115.1Isopropylmalate/homocitrate/citramalate synthase. (533 aa)
AGI47173.1Hypothetical protein. (342 aa)
AGI47202.1Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (272 aa)
AGI47209.1Transaldolase. (219 aa)
AGI47266.1Pyruvate-formate lyase-activating enzyme. (228 aa)
AGI47422.1Radical SAM superfamily protein; Dinitrogenase iron-molybdenum cofactor. (344 aa)
AGI47436.1Putative Fe-S oxidoreductase. (568 aa)
AGI47444.1tRNA-dihydrouridine synthase. (338 aa)
queEOrganic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (209 aa)
AGI47498.1Biotin synthase-related enzyme. (355 aa)
AGI47519.1Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
AGI47529.1Nicotinic acid phosphoribosyltransferase. (397 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (237 aa)
AGI47557.1Homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa)
aroAPutative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (433 aa)
AGI47565.1Thiamine monophosphate synthase. (197 aa)
AGI47566.1Tyrosine lyase ThiH. (383 aa)
AGI47567.1Thiazole-phosphate synthase. (256 aa)
AGI47614.1Isopropylmalate/homocitrate/citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (526 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (213 aa)
AGI47645.1Arylsulfatase regulator (Fe-S oxidoreductase). (379 aa)
aroA-3Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (225 aa)
AGI47797.1Molybdenum cofactor biosynthesis enzyme. (276 aa)
taw1Fe-S oxidoreductase; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (327 aa)
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (203 aa)
pyrDDihydroorotate dehydrogenase (subfamily 1) family protein; Catalyzes the conversion of dihydroorotate to orotate. (298 aa)
AGI48015.1Hypothetical protein. (626 aa)
AGI48195.1Porphobilinogen synthase; Belongs to the ALAD family. (333 aa)
fniIsopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (357 aa)
AGI48372.1Pyruvate-formate lyase-activating enzyme. (337 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
AGI48410.1Glutamate synthase domain 2; Belongs to the glutamate synthase family. (470 aa)
AGI48414.1Indole-3-glycerol phosphate synthase. (263 aa)
trpF-2Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (199 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa)
pdxSPyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (291 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (216 aa)
AGI48487.1Radical SAM domain protein, pyruvate formate-lyase activating enzyme -like protein. (353 aa)
AGI48495.1Histone acetyltransferase, ELP3 family. (510 aa)
Your Current Organism:
Thermoplasmatales archaeon BRNA1
NCBI taxonomy Id: 1054217
Other names: T. archaeon BRNA1
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