(69 nodes) Carbon metabolism network (Thermoplasmatales archaeon BRNA1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AGI47072.1	Malic enzyme. (480 aa)
	AGI47139.1	Putative cobalamin binding protein. (209 aa)
	AGI47161.1	Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (281 aa)
	AGI47180.1	Formylmethanofuran dehydrogenase, subunit E. (175 aa)
	AGI47191.1	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa)
	AGI47207.1	Transketolase, N-terminal subunit. (272 aa)
	AGI47208.1	Transketolase, C-terminal subunit. (316 aa)
	AGI47209.1	Transaldolase. (219 aa)
	AGI47214.1	Ribulose 1,5-bisphosphate carboxylase, large subunit. (412 aa)
	folD	Methenyltetrahydrofolate cyclohydrolase/5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
	AGI47309.1	Dimethylamine corrinoid protein. (213 aa)
	AGI47310.1	Dimethylamine:corrinoid methyltransferase. (459 aa)
	AGI47314.1	Trimethylamine:corrinoid methyltransferase. (474 aa)
	AGI47315.1	Trimethylamine:corrinoid methyltransferase. (484 aa)
	rpiA	Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (230 aa)
	AGI47341.1	Heterodisulfide reductase, subunit A-related polyferredoxin; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (1026 aa)
	AGI47342.1	F420-non-reducing hydrogenase subunit D. (151 aa)
	AGI47343.1	Coenzyme F420-reducing hydrogenase, gamma subunit. (411 aa)
	AGI47344.1	Coenzyme F420-reducing hydrogenase, alpha subunit. (503 aa)
	AGI47352.1	2-oxoglutarate ferredoxin oxidoreductase, gamma subunit. (177 aa)
	AGI47353.1	Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, beta subunit. (250 aa)
	AGI47354.1	Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit. (353 aa)
	AGI47355.1	2-oxoglutarate ferredoxin oxidoreductase, delta subunit. (69 aa)
	AGI47360.1	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (550 aa)
	AGI47465.1	Methyltransferase, MtaA/CmuA family. (337 aa)
	AGI47471.1	Methyl-coenzyme M reductase, beta subunit. (443 aa)
	AGI47473.1	Methyl-coenzyme M reductase, gamma subunit. (259 aa)
	AGI47474.1	Methyl-coenzyme M reductase, alpha subunit. (552 aa)
	AGI47519.1	Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
	eno	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
	AGI47533.1	Putative phosphoglycerate mutase, AP superfamily. (334 aa)
	aroA	Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa)
	AGI47573.1	Isocitrate/isopropylmalate dehydrogenase. (406 aa)
	AGI47584.1	Glucose-6-phosphate isomerase. (340 aa)
	AGI47588.1	Aconitase. (878 aa)
	AGI47594.1	Acetyl-CoA acetyltransferase. (389 aa)
	AGI47648.1	Cysteine synthase. (302 aa)
	aroA-3	Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa)
	tpiA	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (225 aa)
	fbp	D-fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (394 aa)
	AGI47694.1	Serine hydroxymethyltransferase. (427 aa)
	AGI47710.1	Serine O-acetyltransferase. (220 aa)
	fhs	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (560 aa)
	AGI47738.1	Uroporphyrinogen-III decarboxylase. (336 aa)
	AGI47937.1	Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (108 aa)
	AGI48082.1	Monomethylamine methyltransferase MtmB. (459 aa)
	AGI48083.1	Monomethylamine methyltransferase MtmB. (461 aa)
	AGI48090.1	Trimethylamine corrinoid protein. (216 aa)
	AGI48091.1	Trimethylamine:corrinoid methyltransferase. (494 aa)
	AGI48092.1	Dimethylamine:corrinoid methyltransferase. (469 aa)
	AGI48093.1	Dimethylamine corrinoid protein. (213 aa)
	AGI48153.1	Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, beta subunit. (317 aa)
	AGI48154.1	Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit. (391 aa)
	AGI48155.1	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (94 aa)
	AGI48156.1	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family. (185 aa)
	AGI48157.1	Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (780 aa)
	AGI48259.1	CoB--CoM heterodisulfide reductase subunit B. (285 aa)
	AGI48260.1	CoB--CoM heterodisulfide reductase, subunit C. (166 aa)
	AGI48362.1	Putative sugar phosphate isomerase involved in capsule formation. (177 aa)
	AGI48369.1	Fe-S oxidoreductase. (354 aa)
	pgk	3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
	gap	Glyceraldehyde-3-phosphate dehydrogenase. (337 aa)
	AGI48437.1	Cysteine synthase. (308 aa)
	AGI48472.1	Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like protein. (221 aa)
	AGI48505.1	Fe-S oxidoreductase. (395 aa)
	AGI48519.1	Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta region. (214 aa)
	AGI48520.1	Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha region. (290 aa)
	AGI48531.1	3-hexulose-6-phosphate synthase. (430 aa)
	AGI48540.1	acetyl-CoA acetyltransferase. (393 aa)

Your Current Organism:

Thermoplasmatales archaeon BRNA1

NCBI taxonomy Id: 1054217
Other names: T. archaeon BRNA1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGI47072.1	AGI47209.1	TALC_00057	TALC_00195	Malic enzyme.	Transaldolase.	0.612
AGI47072.1	AGI47353.1	TALC_00057	TALC_00344	Malic enzyme.	Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, beta subunit.	0.906
AGI47072.1	AGI47354.1	TALC_00057	TALC_00345	Malic enzyme.	Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit.	0.910
AGI47072.1	AGI48153.1	TALC_00057	TALC_01165	Malic enzyme.	Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, beta subunit.	0.918
AGI47072.1	AGI48154.1	TALC_00057	TALC_01166	Malic enzyme.	Pyruvate:ferredoxin oxidoreductase-related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit.	0.910
AGI47072.1	AGI48155.1	TALC_00057	TALC_01167	Malic enzyme.	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family.	0.903
AGI47072.1	AGI48156.1	TALC_00057	TALC_01168	Malic enzyme.	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family.	0.906
AGI47072.1	AGI48157.1	TALC_00057	TALC_01169	Malic enzyme.	Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.	0.920
AGI47072.1	AGI48519.1	TALC_00057	TALC_01553	Malic enzyme.	Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta region.	0.980
AGI47072.1	AGI48520.1	TALC_00057	TALC_01554	Malic enzyme.	Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha region.	0.932
AGI47072.1	AGI48531.1	TALC_00057	TALC_01565	Malic enzyme.	3-hexulose-6-phosphate synthase.	0.554
AGI47139.1	AGI47309.1	TALC_00124	TALC_00300	Putative cobalamin binding protein.	Dimethylamine corrinoid protein.	0.683
AGI47139.1	AGI47310.1	TALC_00124	TALC_00301	Putative cobalamin binding protein.	Dimethylamine:corrinoid methyltransferase.	0.652
AGI47139.1	AGI47314.1	TALC_00124	TALC_00305	Putative cobalamin binding protein.	Trimethylamine:corrinoid methyltransferase.	0.967
AGI47139.1	AGI47315.1	TALC_00124	TALC_00306	Putative cobalamin binding protein.	Trimethylamine:corrinoid methyltransferase.	0.967
AGI47139.1	AGI47465.1	TALC_00124	TALC_00463	Putative cobalamin binding protein.	Methyltransferase, MtaA/CmuA family.	0.968
AGI47139.1	AGI47471.1	TALC_00124	TALC_00469	Putative cobalamin binding protein.	Methyl-coenzyme M reductase, beta subunit.	0.650
AGI47139.1	AGI47473.1	TALC_00124	TALC_00471	Putative cobalamin binding protein.	Methyl-coenzyme M reductase, gamma subunit.	0.654
AGI47139.1	AGI47474.1	TALC_00124	TALC_00472	Putative cobalamin binding protein.	Methyl-coenzyme M reductase, alpha subunit.	0.651
AGI47139.1	AGI47738.1	TALC_00124	TALC_00742	Putative cobalamin binding protein.	Uroporphyrinogen-III decarboxylase.	0.968