STRINGSTRING
aroK-2 aroK-2 pfkA pfkA MELS_1865 MELS_1865 ppk ppk pyrH pyrH gmk gmk MELS_1756 MELS_1756 MELS_1723 MELS_1723 MELS_1500 MELS_1500 MELS_1463 MELS_1463 MELS_1447 MELS_1447 MELS_1407 MELS_1407 coaE coaE MELS_1353 MELS_1353 MELS_1340 MELS_1340 MELS_1339 MELS_1339 MELS_1269 MELS_1269 thiL thiL MELS_1225 MELS_1225 MELS_1206 MELS_1206 hldE hldE MELS_1146 MELS_1146 MELS_1144 MELS_1144 nadK nadK MELS_0999 MELS_0999 MELS_0967 MELS_0967 MELS_0965 MELS_0965 thrB thrB cmk cmk MELS_0900 MELS_0900 MELS_0899 MELS_0899 MELS_0898 MELS_0898 MELS_0892 MELS_0892 pgk pgk argB argB MELS_0812 MELS_0812 MELS_0811 MELS_0811 adk adk MELS_0731 MELS_0731 MELS_0702 MELS_0702 MELS_0677 MELS_0677 thiM-2 thiM-2 MELS_2102 MELS_2102 MELS_2095 MELS_2095 proB proB MELS_2060 MELS_2060 ackA ackA MELS_0675 MELS_0675 MELS_0659 MELS_0659 MELS_0658 MELS_0658 glpK glpK MELS_0629 MELS_0629 MELS_0599 MELS_0599 MELS_0574 MELS_0574 MELS_0557 MELS_0557 MELS_0530 MELS_0530 MELS_0517 MELS_0517 MELS_0514 MELS_0514 MELS_0467 MELS_0467 MELS_0420 MELS_0420 MELS_0395 MELS_0395 MELS_0392 MELS_0392 MELS_0384 MELS_0384 MELS_0382 MELS_0382 MELS_0364 MELS_0364 MELS_0335 MELS_0335 MELS_0324 MELS_0324 aroK aroK prs prs thiM thiM coaX coaX MELS_0112 MELS_0112 ispE ispE lpxK lpxK MELS_0031 MELS_0031 MELS_0029 MELS_0029 MELS_2043 MELS_2043
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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aroK-2Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
MELS_1865Putative gluconate kinase. (519 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (718 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
MELS_1756Kinase domain protein. (638 aa)
MELS_1723Signal transduction histidine kinase-like protein. (479 aa)
MELS_1500Toxin-antitoxin system. (134 aa)
MELS_1463Putative uncharacterized protein. (239 aa)
MELS_1447Carbohydrate kinase. (505 aa)
MELS_1407Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (309 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa)
MELS_1353ATP:guanido phosphotransferase. (354 aa)
MELS_1340Pyruvate kinase; Belongs to the pyruvate kinase family. (582 aa)
MELS_1339Glycerate kinase; Belongs to the glycerate kinase type-1 family. (381 aa)
MELS_1269ATPase. (470 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (324 aa)
MELS_1225Phosphoribulokinase/uridine kinase family protein. (550 aa)
MELS_1206Cytidylate kinase. (197 aa)
hldEBifunctional protein hldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (493 aa)
MELS_1146ATPase. (517 aa)
MELS_11442-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. (160 aa)
nadKProbable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (290 aa)
MELS_0999Adenosylcobalamin biosynthesis protein CobU. (191 aa)
MELS_0967His Kinase A (Phosphoacceptor) domain./Histidine kinase-. (424 aa)
MELS_0965relA/SpoT domain protein. (204 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa)
cmkCytidylate kinase. (222 aa)
MELS_0900Putative uncharacterized protein. (125 aa)
MELS_0899Dihydroxyacetone kinase. (201 aa)
MELS_0898Dihydroxyacetone kinase. (329 aa)
MELS_0892Integral membrane sensor signal transduction histidine kinase. (476 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (393 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (302 aa)
MELS_0812Capsular exopolysaccharide family. (232 aa)
MELS_0811Lipopolysaccharide biosynthesis protein. (485 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
MELS_0731Phosphomethylpyrimidine kinase. (268 aa)
MELS_0702Phosphotransferase system PTS. (461 aa)
MELS_0677Selenide. (317 aa)
thiM-2Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (270 aa)
MELS_2102Integral membrane sensor signal transduction histidine kinase. (496 aa)
MELS_2095Aspartokinase; Belongs to the aspartokinase family. (407 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa)
MELS_2060Putative pyridoxal kinase; Belongs to the pyridoxine kinase family. (273 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
MELS_0675ATPase. (499 aa)
MELS_0659Putative uncharacterized protein. (441 aa)
MELS_0658Putative uncharacterized protein. (449 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (501 aa)
MELS_0629Pyruvate kinase; Belongs to the pyruvate kinase family. (582 aa)
MELS_0599Putative uncharacterized protein; Belongs to the carbamate kinase family. (316 aa)
MELS_0574Lipid kinase. (298 aa)
MELS_05572-dehydro-3-deoxygluconokinase. (315 aa)
MELS_0530Two-component system sensor histidine kinase. (382 aa)
MELS_0517Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (543 aa)
MELS_0514Hexose kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (301 aa)
MELS_0467Polyphosphate:nucleotide phosphotransferase. (304 aa)
MELS_0420Cytidylate kinase. (203 aa)
MELS_0395Putative pyridoxal kinase; Belongs to the pyridoxine kinase family. (275 aa)
MELS_0392dTMP kinase. (222 aa)
MELS_0384Hexokinase. (414 aa)
MELS_0382PTS system maltose-specific EIICB component. (720 aa)
MELS_0364Possible glucokinase. (292 aa)
MELS_0335PTS system glucose-specific EIICBA component. (723 aa)
MELS_0324Hexokinase. (422 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (168 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (277 aa)
coaXType III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (254 aa)
MELS_0112Histidine kinase. (566 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (288 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (381 aa)
MELS_0031Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (802 aa)
MELS_0029Putative phosphotransferase HMPREF0889_1301; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (273 aa)
MELS_2043Putative uncharacterized protein. (540 aa)
Your Current Organism:
Megasphaera elsdenii
NCBI taxonomy Id: 1064535
Other names: M. elsdenii DSM 20460, Megasphaera elsdenii ATCC 25940, Megasphaera elsdenii DSM 20460, Megasphaera elsdenii LC1, Megasphaera elsdenii str. DSM 20460, Megasphaera elsdenii strain DSM 20460
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