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MELS_0443 MELS_0443 MELS_0021 MELS_0021 MELS_0064 MELS_0064 fabZ fabZ argH argH ribBA ribBA MELS_0169 MELS_0169 hisF hisF hisH hisH hisB hisB trpA trpA trpB trpB trpC trpC MELS_0256 MELS_0256 aroD aroD aroC aroC aroB aroB MELS_0284 MELS_0284 MELS_0290 MELS_0290 MELS_0291 MELS_0291 ilvD ilvD MELS_0333 MELS_0333 MELS_0356 MELS_0356 MELS_0408 MELS_0408 eno eno MELS_0465 MELS_0465 MELS_0490 MELS_0490 MELS_0494 MELS_0494 MELS_0554 MELS_0554 MELS_0558 MELS_0558 MELS_0602 MELS_0602 moaC moaC MELS_0618 MELS_0618 MELS_0669 MELS_0669 MELS_0682 MELS_0682 MELS_0685 MELS_0685 murQ murQ MELS_0705 MELS_0705 MELS_0743 MELS_0743 MELS_0745 MELS_0745 MELS_0746 MELS_0746 pyrF pyrF dacA dacA MELS_0954 MELS_0954 dapA dapA MELS_1065 MELS_1065 MELS_1143 MELS_1143 MELS_1151 MELS_1151 MELS_1152 MELS_1152 queE queE MELS_1258 MELS_1258 MELS_1276 MELS_1276 MELS_1344 MELS_1344 ispDF ispDF mutM mutM MELS_1496 MELS_1496 leuC leuC leuD leuD MELS_1576 MELS_1576 MELS_1583 MELS_1583 thiC thiC fumC fumC MELS_1675 MELS_1675 MELS_1765 MELS_1765 MELS_1779 MELS_1779 speD speD cobD cobD MELS_1854 MELS_1854 MELS_1867 MELS_1867 MELS_1869 MELS_1869 MELS_1870 MELS_1870 MELS_1887 MELS_1887 mltG mltG MELS_1998 MELS_1998 MELS_2003 MELS_2003 pckA pckA MELS_2159 MELS_2159 nth nth MELS_2187 MELS_2187 MELS_2204 MELS_2204
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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MELS_0443Putative uncharacterized protein. (442 aa)
MELS_0021Phosphatidylserine decarboxylase. (217 aa)
MELS_0064HMGL-like protein. (449 aa)
fabZ(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (148 aa)
argHArgininosuccinate lyase. (477 aa)
ribBARiboflavin biosynthesis protein ribBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (405 aa)
MELS_0169Putative CoA-substrate-specific enzyme activase. (1431 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa)
hisHPutative uncharacterized protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa)
hisBImidazoleglycerol-phosphate dehydratase. (194 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa)
MELS_0256Putative uncharacterized protein. (188 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (249 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (356 aa)
MELS_02843-deoxy-7-phosphoheptulonate synthase. (340 aa)
MELS_0290L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (294 aa)
MELS_0291L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (219 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (550 aa)
MELS_0333Putative uncharacterized protein. (185 aa)
MELS_0356UPF0597 protein HMPREF0889_1406; Belongs to the UPF0597 family. (439 aa)
MELS_0408Aspartate ammonia-lyase. (478 aa)
enoEnolase 2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
MELS_0465Cobalt chelatase. (333 aa)
MELS_0490Aconitase protein. (760 aa)
MELS_0494Alpha-acetolactate decarboxylase. (243 aa)
MELS_0554Putative uncharacterized protein. (496 aa)
MELS_0558Possible 4-hydroxy-2-oxoglutarate aldolase. (212 aa)
MELS_0602Putative uncharacterized protein. (403 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (165 aa)
MELS_0618Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (325 aa)
MELS_0669UPF0272 protein TcarDRAFT_2407. (283 aa)
MELS_0682Dimethylmenaquinone methyltransferase. (229 aa)
MELS_0685Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (303 aa)
MELS_0705Carbonate dehydratase. (188 aa)
MELS_0743Glyoxalase family protein. (304 aa)
MELS_0745Putative 2-hydroxyglutaryl-CoA dehydratase D-component. (428 aa)
MELS_0746Putative R-phenyllactate dehydratase. (372 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (237 aa)
dacAPutative uncharacterized protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (270 aa)
MELS_0954UPF0272 protein TcarDRAFT_1530. (148 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
MELS_1065Putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit. (135 aa)
MELS_1143Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa)
MELS_1151Amidohydrolase family protein. (274 aa)
MELS_1152Putative queuosine biosynthesis protein QueD. (109 aa)
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (210 aa)
MELS_1258Diaminopimelate decarboxylase. (417 aa)
MELS_1276Threonine ammonia-lyase. (411 aa)
MELS_1344Aromatic amino acid beta-eliminating lyase/threonine aldolase. (344 aa)
ispDF2C-methyl-D-erythritol 2; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (386 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (274 aa)
MELS_1496UPF0597 protein HMPREF0889_1406; Belongs to the UPF0597 family. (435 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa)
MELS_15763-dehydroquinate dehydratase. (245 aa)
MELS_1583Threonine synthase. (500 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
MELS_1675Glutamine amidotransferase. (200 aa)
MELS_1765Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (404 aa)
MELS_1779Putative L-ribulose-5-phosphate 4-epimerase. (210 aa)
speDS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (254 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa)
MELS_1854Fructose-1. (321 aa)
MELS_1867Siroheme synthase. (215 aa)
MELS_1869Possible uroporphyrinogen-III synthase. (506 aa)
MELS_1870Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (329 aa)
MELS_1887dTDP-glucose 4; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (340 aa)
mltGPutative uncharacterized protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (352 aa)
MELS_1998Putative uncharacterized protein; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine. (167 aa)
MELS_2003Lactoylglutathione lyase and related lyases. (127 aa)
pckAPhosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa)
MELS_2159Malic enzyme. (417 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (210 aa)
MELS_2187Threonine aldolase. (349 aa)
MELS_2204Glyoxalase family protein. (120 aa)
Your Current Organism:
Megasphaera elsdenii
NCBI taxonomy Id: 1064535
Other names: M. elsdenii DSM 20460, Megasphaera elsdenii ATCC 25940, Megasphaera elsdenii DSM 20460, Megasphaera elsdenii LC1, Megasphaera elsdenii str. DSM 20460, Megasphaera elsdenii strain DSM 20460
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