(21 nodes) mRNA decay by 5 to 3 exoribonuclease, and Eukaryotic initiation factor 4G binding network (Naumovozyma castellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	NCAS0A03890	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (90 aa)
	NCAS0A11810	Sm domain-containing protein. (83 aa)
	NCAS0A14060	Uncharacterized protein; Belongs to the DEAD box helicase family. (510 aa)
	NCAS0A14510	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (182 aa)
	NCAS0B07110	Sm domain-containing protein. (75 aa)
	NCAS0B07980	U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation. (175 aa)
	NCAS0B04420	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
	NCAS0C00510	Uncharacterized protein. (445 aa)
	NCAS0C03050	Nudix hydrolase domain-containing protein. (346 aa)
	NCAS0C04170	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1488 aa)
	NCAS0C04290	Uncharacterized protein. (211 aa)
	NCAS0D01690	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (136 aa)
	NCAS0D04130	Uncharacterized protein. (587 aa)
	NCAS0D04840	Uncharacterized protein. (902 aa)
	NCAS0E00900	Uncharacterized protein. (370 aa)
	NCAS0F00300	Nudix hydrolase domain-containing protein. (176 aa)
	NCAS0F02350	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (356 aa)
	NCAS0G01630	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (246 aa)
	NCAS0G02500	Nudix hydrolase domain-containing protein. (864 aa)
	NCAS0G03260	Uncharacterized protein. (573 aa)
	NCAS0J01950	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (84 aa)

Your Current Organism:

Naumovozyma castellii

NCBI taxonomy Id: 1064592
Other names: N. castellii CBS 4309, Naumovozyma castellii CBS 4309

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NCAS0A03890	NCAS0A11810	G0V656	G0V8E1	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Sm domain-containing protein.	0.999
NCAS0A03890	NCAS0A14060	G0V656	G0V915	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.694
NCAS0A03890	NCAS0A14510	G0V656	G0V959	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
NCAS0A03890	NCAS0B04420	G0V656	G0VAK0	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
NCAS0A03890	NCAS0B07110	G0V656	G0VA65	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Sm domain-containing protein.	0.999
NCAS0A03890	NCAS0B07980	G0V656	G0VAF2	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.	0.999
NCAS0A03890	NCAS0C00510	G0V656	G0VC34	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Uncharacterized protein.	0.991
NCAS0A03890	NCAS0C04170	G0V656	G0VD45	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	0.766
NCAS0A03890	NCAS0C04290	G0V656	G0VD57	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Uncharacterized protein.	0.759
NCAS0A03890	NCAS0D01690	G0V656	G0VDW0	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
NCAS0A03890	NCAS0D04840	G0V656	G0VES4	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Uncharacterized protein.	0.999
NCAS0A03890	NCAS0E00900	G0V656	G0VF95	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Uncharacterized protein.	0.487
NCAS0A03890	NCAS0G01630	G0V656	G0VI16	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.	0.536
NCAS0A03890	NCAS0G02500	G0V656	G0VIA2	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Nudix hydrolase domain-containing protein.	0.792
NCAS0A03890	NCAS0G03260	G0V656	G0VIH8	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	Uncharacterized protein.	0.752
NCAS0A03890	NCAS0J01950	G0V656	G0VKY6	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
NCAS0A11810	NCAS0A03890	G0V8E1	G0V656	Sm domain-containing protein.	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	0.999
NCAS0A11810	NCAS0A14060	G0V8E1	G0V915	Sm domain-containing protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.725
NCAS0A11810	NCAS0A14510	G0V8E1	G0V959	Sm domain-containing protein.	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
NCAS0A11810	NCAS0B04420	G0V8E1	G0VAK0	Sm domain-containing protein.	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999