(103 nodes) Inactivation of APC/C via direct inhibition of the APC/C complex, and Cyclin-dependent protein kinase holoenzyme complex network (Malus baccata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C1H46_045012	Uncharacterized protein. (314 aa)
	C1H46_044899	Uncharacterized protein. (101 aa)
	C1H46_043637	GLTSCR1 domain-containing protein. (238 aa)
	C1H46_043289	RNase H domain-containing protein. (374 aa)
	C1H46_040172	Uncharacterized protein. (630 aa)
	C1H46_040171	Uncharacterized protein. (282 aa)
	C1H46_039520	Uncharacterized protein. (217 aa)
	C1H46_039168	Uncharacterized protein. (210 aa)
	C1H46_038044	Protein kinase domain-containing protein. (400 aa)
	C1H46_038046	Protein kinase domain-containing protein. (95 aa)
	C1H46_038048	Uncharacterized protein. (82 aa)
	C1H46_037441	RING-type domain-containing protein. (131 aa)
	C1H46_037144	WD_REPEATS_REGION domain-containing protein. (776 aa)
	C1H46_037032	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (188 aa)
	C1H46_036954	HORMA domain-containing protein. (263 aa)
	C1H46_036287	Uncharacterized protein. (84 aa)
	C1H46_036113	Uncharacterized protein. (77 aa)
	C1H46_036114	Uncharacterized protein. (160 aa)
	C1H46_035471	Uncharacterized protein. (751 aa)
	C1H46_034414	Uncharacterized protein. (596 aa)
	C1H46_034264	GLTSCR1 domain-containing protein. (234 aa)
	C1H46_034176	TPR_REGION domain-containing protein. (133 aa)
	C1H46_033768	Uncharacterized protein. (405 aa)
	C1H46_033123	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (489 aa)
	C1H46_032708	RNase H domain-containing protein. (329 aa)
	C1H46_032423	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (413 aa)
	C1H46_032424	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (445 aa)
	C1H46_032231	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (306 aa)
	C1H46_031978	Protein kinase domain-containing protein. (85 aa)
	C1H46_031320	ANAPC5 domain-containing protein. (938 aa)
	C1H46_031089	APC1_C domain-containing protein. (1379 aa)
	C1H46_031054	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa)
	C1H46_031047	BUB1 N-terminal domain-containing protein. (392 aa)
	C1H46_030500	BUB1 N-terminal domain-containing protein. (513 aa)
	C1H46_029523	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (304 aa)
	C1H46_029240	WD_REPEATS_REGION domain-containing protein; Belongs to the actin family. (813 aa)
	C1H46_028546	WD_REPEATS_REGION domain-containing protein. (453 aa)
	C1H46_028538	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (1201 aa)
	C1H46_028349	Uncharacterized protein. (65 aa)
	C1H46_028367	RNase H domain-containing protein. (636 aa)
	C1H46_028366	RNase H domain-containing protein. (329 aa)
	C1H46_028141	TPR_REGION domain-containing protein. (625 aa)
	C1H46_027654	Uncharacterized protein. (438 aa)
	C1H46_027262	Uncharacterized protein. (330 aa)
	C1H46_027035	WD_REPEATS_REGION domain-containing protein. (191 aa)
	C1H46_027061	CULLIN_2 domain-containing protein; Belongs to the cullin family. (868 aa)
	C1H46_026188	Uncharacterized protein. (68 aa)
	C1H46_025528	TPR_REGION domain-containing protein. (578 aa)
	C1H46_025637	WD_REPEATS_REGION domain-containing protein. (286 aa)
	C1H46_025132	Uncharacterized protein. (57 aa)
	C1H46_025114	APC2 domain-containing protein. (138 aa)
	C1H46_025111	APC2 domain-containing protein. (135 aa)
	C1H46_024004	Cyclin N-terminal domain-containing protein. (574 aa)
	C1H46_023644	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (192 aa)
	C1H46_023752	Uncharacterized protein. (135 aa)
	C1H46_023523	Uncharacterized protein. (199 aa)
	C1H46_023575	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (521 aa)
	C1H46_023532	Cyclin_C domain-containing protein; Belongs to the cyclin family. (213 aa)
	C1H46_023525	Cyclin_C domain-containing protein; Belongs to the cyclin family. (439 aa)
	C1H46_022919	BUB1 N-terminal domain-containing protein. (434 aa)
	C1H46_021937	Protein kinase domain-containing protein. (605 aa)
	C1H46_020764	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (291 aa)
	C1H46_019518	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (315 aa)
	C1H46_019361	Protein kinase domain-containing protein. (503 aa)
	C1H46_019321	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (353 aa)
	C1H46_019320	Uncharacterized protein. (114 aa)
	C1H46_018697	Protein kinase domain-containing protein. (538 aa)
	C1H46_018274	RNase H domain-containing protein. (199 aa)
	C1H46_017086	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (272 aa)
	C1H46_016375	WD_REPEATS_REGION domain-containing protein. (447 aa)
	C1H46_015527	SANT domain-containing protein. (140 aa)
	C1H46_015410	Uncharacterized protein. (356 aa)
	C1H46_015157	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (358 aa)
	C1H46_014718	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (603 aa)
	C1H46_014719	Cyclin N-terminal domain-containing protein. (279 aa)
	C1H46_015156	Uncharacterized protein; Belongs to the cyclin family. (361 aa)
	C1H46_014304	Uncharacterized protein. (199 aa)
	C1H46_014720	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (498 aa)
	C1H46_013980	HTH myb-type domain-containing protein. (288 aa)
	C1H46_013824	Uncharacterized protein. (433 aa)
	C1H46_013097	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (323 aa)
	C1H46_013099	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (135 aa)
	C1H46_012484	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
	C1H46_012036	Uncharacterized protein. (769 aa)
	C1H46_011714	Uncharacterized protein; Belongs to the cyclin family. (648 aa)
	C1H46_011691	Uncharacterized protein. (561 aa)
	C1H46_011323	TPR_REGION domain-containing protein. (549 aa)
	C1H46_001129	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (88 aa)
	C1H46_009374	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (498 aa)
	C1H46_008236	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (446 aa)
	C1H46_008158	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (400 aa)
	C1H46_008159	Uncharacterized protein. (504 aa)
	C1H46_007233	WD_REPEATS_REGION domain-containing protein. (582 aa)
	C1H46_006537	Rhodanese domain-containing protein. (132 aa)
	C1H46_005126	Uncharacterized protein. (272 aa)
	C1H46_004069	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (354 aa)
	C1H46_003770	BUB1 N-terminal domain-containing protein. (75 aa)
	C1H46_003780	WD_REPEATS_REGION domain-containing protein. (487 aa)
	C1H46_003631	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (406 aa)
	C1H46_003632	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (361 aa)
	C1H46_003818	Uncharacterized protein; Belongs to the cyclin family. (539 aa)
	C1H46_001804	WD_REPEATS_REGION domain-containing protein. (477 aa)
	C1H46_000557	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (439 aa)

Your Current Organism:

Malus baccata

NCBI taxonomy Id: 106549
Other names: M. baccata, Malus baccata (L.) Borkh., shan jing zi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1H46_000557	C1H46_001129	A0A540NSA2	A0A540N0G9	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.843
C1H46_000557	C1H46_001804	A0A540NSA2	A0A540NNI1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	WD_REPEATS_REGION domain-containing protein.	0.749
C1H46_000557	C1H46_003631	A0A540NSA2	A0A540NI50	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.614
C1H46_000557	C1H46_003632	A0A540NSA2	A0A540NI99	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.613
C1H46_000557	C1H46_003770	A0A540NSA2	A0A540NHY2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	BUB1 N-terminal domain-containing protein.	0.541
C1H46_000557	C1H46_003780	A0A540NSA2	A0A540NHZ4	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	WD_REPEATS_REGION domain-containing protein.	0.749
C1H46_000557	C1H46_003818	A0A540NSA2	A0A540NJB8	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein; Belongs to the cyclin family.	0.615
C1H46_000557	C1H46_004069	A0A540NSA2	A0A540NH26	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.614
C1H46_000557	C1H46_005126	A0A540NSA2	A0A540NDT5	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.801
C1H46_000557	C1H46_006537	A0A540NSA2	A0A540NA29	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Rhodanese domain-containing protein.	0.841
C1H46_000557	C1H46_007233	A0A540NSA2	A0A540N9M0	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	WD_REPEATS_REGION domain-containing protein.	0.749
C1H46_000557	C1H46_011323	A0A540NSA2	A0A540MWI3	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	TPR_REGION domain-containing protein.	0.661
C1H46_000557	C1H46_011691	A0A540NSA2	A0A540MVC7	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.529
C1H46_000557	C1H46_012036	A0A540NSA2	A0A540MUB7	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.621
C1H46_000557	C1H46_012484	A0A540NSA2	A0A540MU13	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.735
C1H46_000557	C1H46_013097	A0A540NSA2	A0A540MR81	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.618
C1H46_000557	C1H46_013099	A0A540NSA2	A0A540MST0	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.583
C1H46_000557	C1H46_013824	A0A540NSA2	A0A540MQD3	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.697
C1H46_000557	C1H46_013980	A0A540NSA2	A0A540MNN1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	HTH myb-type domain-containing protein.	0.749
C1H46_000557	C1H46_014304	A0A540NSA2	A0A540MMN6	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.611