(90 nodes) Folate biosynthesis network (Malus baccata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C1H46_026725	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (308 aa)
	C1H46_027244	Uncharacterized protein. (598 aa)
	C1H46_027245	Uncharacterized protein. (239 aa)
	C1H46_027611	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	C1H46_029600	Uncharacterized protein. (170 aa)
	C1H46_029663	Uncharacterized protein; Belongs to the universal ribosomal protein uL23 family. (690 aa)
	C1H46_030322	MFS domain-containing protein. (483 aa)
	C1H46_030515	Uncharacterized protein. (467 aa)
	C1H46_030321	MFS domain-containing protein. (483 aa)
	C1H46_030822	Rhodanese domain-containing protein. (453 aa)
	C1H46_032081	Uncharacterized protein. (587 aa)
	C1H46_032232	FSH1 domain-containing protein. (309 aa)
	C1H46_032234	FSH1 domain-containing protein. (161 aa)
	C1H46_032945	Mur_ligase_M domain-containing protein. (555 aa)
	C1H46_032764	Aminotran_5 domain-containing protein. (597 aa)
	C1H46_033217	Uncharacterized protein. (179 aa)
	C1H46_033373	Uncharacterized protein. (956 aa)
	C1H46_033866	Uncharacterized protein. (198 aa)
	C1H46_033806	Uncharacterized protein. (491 aa)
	C1H46_034168	Folate gamma-glutamyl hydrolase. (359 aa)
	C1H46_034306	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (526 aa)
	C1H46_034539	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (349 aa)
	C1H46_035696	Uncharacterized protein. (350 aa)
	C1H46_036514	Uncharacterized protein. (946 aa)
	C1H46_037886	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (602 aa)
	C1H46_037841	Mur_ligase_M domain-containing protein. (647 aa)
	C1H46_009478	ZT_dimer domain-containing protein. (394 aa)
	C1H46_039049	FSH1 domain-containing protein. (318 aa)
	C1H46_039480	Uncharacterized protein. (303 aa)
	C1H46_039995	Pterin-binding domain-containing protein. (516 aa)
	C1H46_040272	Rhodanese domain-containing protein. (457 aa)
	C1H46_040978	Rhodanese domain-containing protein. (635 aa)
	C1H46_041474	FSH1 domain-containing protein. (291 aa)
	C1H46_042665	Uncharacterized protein. (280 aa)
	C1H46_042666	Uncharacterized protein. (366 aa)
	C1H46_043148	Uncharacterized protein. (534 aa)
	C1H46_000102	GTP_cyclohydro2 domain-containing protein. (539 aa)
	C1H46_000316	Elongation factor G, chloroplastic; Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl- tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (779 aa)
	C1H46_001815	Uncharacterized protein. (630 aa)
	C1H46_001503	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (369 aa)
	C1H46_001655	Tr-type G domain-containing protein. (586 aa)
	C1H46_002052	Uncharacterized protein. (460 aa)
	C1H46_037887	Uncharacterized protein. (134 aa)
	C1H46_009441	Uncharacterized protein. (198 aa)
	C1H46_008512	Mur_ligase_M domain-containing protein. (660 aa)
	C1H46_007322	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (758 aa)
	C1H46_006956	GTP_cyclohydro2 domain-containing protein. (455 aa)
	C1H46_006955	Uncharacterized protein. (79 aa)
	C1H46_006363	Uncharacterized protein. (365 aa)
	C1H46_006117	Elp3 domain-containing protein. (405 aa)
	C1H46_005593	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (817 aa)
	C1H46_005174	Uncharacterized protein. (194 aa)
	C1H46_004645	Uncharacterized protein. (439 aa)
	C1H46_003355	ZT_dimer domain-containing protein. (393 aa)
	C1H46_009881	MFS domain-containing protein. (486 aa)
	C1H46_011712	ZT_dimer domain-containing protein. (405 aa)
	C1H46_011310	Folate gamma-glutamyl hydrolase. (387 aa)
	C1H46_012345	ZT_dimer domain-containing protein. (403 aa)
	C1H46_013125	ZT_dimer domain-containing protein. (407 aa)
	C1H46_013195	Uncharacterized protein. (322 aa)
	C1H46_013630	Uncharacterized protein. (108 aa)
	C1H46_014281	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (668 aa)
	C1H46_014592	Uncharacterized protein. (145 aa)
	C1H46_015243	Glutamine amidotransferase type-1 domain-containing protein. (178 aa)
	C1H46_015244	Glutamine amidotransferase type-1 domain-containing protein. (775 aa)
	C1H46_015867	Uncharacterized protein. (144 aa)
	C1H46_015544	Uncharacterized protein. (67 aa)
	C1H46_015838	Uncharacterized protein. (209 aa)
	C1H46_016619	Uncharacterized protein. (859 aa)
	C1H46_017054	Glutamine amidotransferase type-1 domain-containing protein. (986 aa)
	C1H46_017841	Uncharacterized protein. (618 aa)
	C1H46_018216	Uncharacterized protein. (2404 aa)
	C1H46_018514	Uncharacterized protein. (956 aa)
	C1H46_018513	Uncharacterized protein. (952 aa)
	C1H46_019032	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (510 aa)
	C1H46_019368	ZT_dimer domain-containing protein. (488 aa)
	C1H46_019547	Uncharacterized protein. (100 aa)
	C1H46_020178	Rhodanese_C domain-containing protein. (237 aa)
	C1H46_020579	Uncharacterized protein. (598 aa)
	C1H46_021688	DRY_EERY domain-containing protein. (586 aa)
	C1H46_021687	DRY_EERY domain-containing protein. (586 aa)
	C1H46_021901	Uncharacterized protein. (399 aa)
	C1H46_023515	ZT_dimer domain-containing protein. (404 aa)
	C1H46_023517	ZT_dimer domain-containing protein. (120 aa)
	C1H46_023520	Uncharacterized protein. (217 aa)
	C1H46_023516	Uncharacterized protein. (165 aa)
	C1H46_024527	MOSC domain-containing protein. (148 aa)
	C1H46_025147	Uncharacterized protein. (363 aa)
	C1H46_025092	MoaC domain-containing protein. (231 aa)
	C1H46_026376	7,8-dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (142 aa)

Your Current Organism:

Malus baccata

NCBI taxonomy Id: 106549
Other names: M. baccata, Malus baccata (L.) Borkh., shan jing zi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1H46_000102	C1H46_002052	A0A540NU99	A0A540NMZ3	GTP_cyclohydro2 domain-containing protein.	Uncharacterized protein.	0.963
C1H46_000102	C1H46_006117	A0A540NU99	A0A540NBB4	GTP_cyclohydro2 domain-containing protein.	Elp3 domain-containing protein.	0.921
C1H46_000102	C1H46_008512	A0A540NU99	A0A540N494	GTP_cyclohydro2 domain-containing protein.	Mur_ligase_M domain-containing protein.	0.743
C1H46_000102	C1H46_015544	A0A540NU99	A0A540MJF2	GTP_cyclohydro2 domain-containing protein.	Uncharacterized protein.	0.483
C1H46_000102	C1H46_019032	A0A540NU99	A0A540M9H0	GTP_cyclohydro2 domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.517
C1H46_000102	C1H46_025092	A0A540NU99	A0A540LS95	GTP_cyclohydro2 domain-containing protein.	MoaC domain-containing protein.	0.756
C1H46_000102	C1H46_026376	A0A540NU99	A0A540LP30	GTP_cyclohydro2 domain-containing protein.	7,8-dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	0.529
C1H46_000102	C1H46_029663	A0A540NU99	A0A540LE45	GTP_cyclohydro2 domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL23 family.	0.922
C1H46_000102	C1H46_032945	A0A540NU99	A0A540L5F9	GTP_cyclohydro2 domain-containing protein.	Mur_ligase_M domain-containing protein.	0.743
C1H46_000102	C1H46_034306	A0A540NU99	A0A540L1A1	GTP_cyclohydro2 domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.517
C1H46_000102	C1H46_037841	A0A540NU99	A0A540KR00	GTP_cyclohydro2 domain-containing protein.	Mur_ligase_M domain-containing protein.	0.743
C1H46_000102	C1H46_037886	A0A540NU99	A0A540KRG5	GTP_cyclohydro2 domain-containing protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.743
C1H46_000102	C1H46_037887	A0A540NU99	A0A540KQT9	GTP_cyclohydro2 domain-containing protein.	Uncharacterized protein.	0.743
C1H46_000102	C1H46_039995	A0A540NU99	A0A540KJT9	GTP_cyclohydro2 domain-containing protein.	Pterin-binding domain-containing protein.	0.483
C1H46_000316	C1H46_019032	A0A540NSK4	A0A540M9H0	Elongation factor G, chloroplastic; Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl- tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.534
C1H46_000316	C1H46_034306	A0A540NSK4	A0A540L1A1	Elongation factor G, chloroplastic; Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl- tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.534
C1H46_001503	C1H46_013630	A0A540NP89	A0A540MPG9	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein.	0.516
C1H46_001503	C1H46_015838	A0A540NP89	A0A540MIH4	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein.	0.516
C1H46_001503	C1H46_019032	A0A540NP89	A0A540M9H0	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.907
C1H46_001503	C1H46_026725	A0A540NP89	A0A540LML8	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.921