(7 nodes) Mre11 complex, and BRCA1-BARD1 complex network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	LOC101476906	BRCA1 associated RING domain 1. (713 aa)
	Atm	Uncharacterized protein. (139 aa)
	LOC112430055	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (658 aa)
	Rbbp8	SAE2 domain-containing protein. (75 aa)
	brca1	Uncharacterized protein. (1389 aa)
	nbn	Nibrin. (843 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	LOC101476906	ENSMZEP00005016548	ENSMZEP00005013356	Uncharacterized protein.	BRCA1 associated RING domain 1.	0.899
Atm	LOC112430055	ENSMZEP00005016548	ENSMZEP00005021542	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.993
Atm	Rbbp8	ENSMZEP00005016548	ENSMZEP00005027054	Uncharacterized protein.	SAE2 domain-containing protein.	0.849
Atm	brca1	ENSMZEP00005016548	ENSMZEP00005028411	Uncharacterized protein.	Uncharacterized protein.	0.992
Atm	nbn	ENSMZEP00005016548	ENSMZEP00005030109	Uncharacterized protein.	Nibrin.	0.997
Atm	rad50	ENSMZEP00005016548	ENSMZEP00005003251	Uncharacterized protein.	RAD50 homolog, double strand break repair protein.	0.985
LOC101476906	Atm	ENSMZEP00005013356	ENSMZEP00005016548	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.899
LOC101476906	LOC112430055	ENSMZEP00005013356	ENSMZEP00005021542	BRCA1 associated RING domain 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.969
LOC101476906	Rbbp8	ENSMZEP00005013356	ENSMZEP00005027054	BRCA1 associated RING domain 1.	SAE2 domain-containing protein.	0.994
LOC101476906	brca1	ENSMZEP00005013356	ENSMZEP00005028411	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.999
LOC101476906	nbn	ENSMZEP00005013356	ENSMZEP00005030109	BRCA1 associated RING domain 1.	Nibrin.	0.982
LOC101476906	rad50	ENSMZEP00005013356	ENSMZEP00005003251	BRCA1 associated RING domain 1.	RAD50 homolog, double strand break repair protein.	0.916
LOC112430055	Atm	ENSMZEP00005021542	ENSMZEP00005016548	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.993
LOC112430055	LOC101476906	ENSMZEP00005021542	ENSMZEP00005013356	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	BRCA1 associated RING domain 1.	0.969
LOC112430055	Rbbp8	ENSMZEP00005021542	ENSMZEP00005027054	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	SAE2 domain-containing protein.	0.994
LOC112430055	brca1	ENSMZEP00005021542	ENSMZEP00005028411	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.972
LOC112430055	nbn	ENSMZEP00005021542	ENSMZEP00005030109	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Nibrin.	0.996
LOC112430055	rad50	ENSMZEP00005021542	ENSMZEP00005003251	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	RAD50 homolog, double strand break repair protein.	0.997
Rbbp8	Atm	ENSMZEP00005027054	ENSMZEP00005016548	SAE2 domain-containing protein.	Uncharacterized protein.	0.849
Rbbp8	LOC101476906	ENSMZEP00005027054	ENSMZEP00005013356	SAE2 domain-containing protein.	BRCA1 associated RING domain 1.	0.994