STRINGSTRING
pole2 pole2 orc5 orc5 gmnn gmnn pola2 pola2 gins1 gins1 mcm5 mcm5 cdc7 cdc7 LOC101485698 LOC101485698 orc3 orc3 cdc6 cdc6 prim2 prim2 mcm7 mcm7 pole4 pole4 pcna pcna cdc45 cdc45 pold2 pold2 pold1 pold1 LOC112436452 LOC112436452 atad5 atad5 orc2 orc2 rfc4 rfc4 mcmbp mcmbp gins4 gins4 dna2 dna2 chtf18 chtf18 LOC112433862 LOC112433862 gins2 gins2 poli poli pold4 pold4 polk polk LOC101469640 LOC101469640 ENSMZEP00005020374 ENSMZEP00005020374 mcm10 mcm10 rev3l rev3l gins3 gins3 orc4 orc4 pole pole mcm2 mcm2 pole3 pole3 ENSMZEP00005022867 ENSMZEP00005022867 orc1 orc1 piezo1 piezo1 cdt1 cdt1 ENSMZEP00005027667 ENSMZEP00005027667 ENSMZEP00005027673 ENSMZEP00005027673 LOC101483840 LOC101483840 rad17 rad17 pola1 pola1 mad2l2 mad2l2 rfc5 rfc5 MCMDC2 MCMDC2 rev1 rev1 timeless timeless dbf4 dbf4 mcm3 mcm3 chtf8 chtf8 rfc1 rfc1 LOC101485137 LOC101485137 pold3 pold3 lig1 lig1 rfc3 rfc3 LOC112434231 LOC112434231 mcm4 mcm4 dscc1 dscc1 ENSMZEP00005034360 ENSMZEP00005034360 prim1 prim1 LOC101476670 LOC101476670 rfc2 rfc2 mcm8 mcm8 polh polh mcm9 mcm9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
orc5Origin recognition complex, subunit 5. (445 aa)
gmnnGeminin DNA replication inhibitor. (233 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (196 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (611 aa)
LOC101485698Zgc:110269. (348 aa)
orc3Origin recognition complex, subunit 3. (720 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (602 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (740 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
pold1DNA polymerase. (1105 aa)
LOC112436452DNA helicase; Belongs to the MCM family. (828 aa)
atad5ATPase family AAA domain containing 5a. (1807 aa)
orc2Uncharacterized protein. (576 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
mcmbpMinichromosome maintenance complex binding protein. (629 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
dna2DNA replication helicase/nuclease 2. (1401 aa)
chtf18AAA domain-containing protein. (922 aa)
LOC112433862TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (315 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (175 aa)
poliPolymerase (DNA directed) iota. (720 aa)
pold4Si:dkey-28b4.7. (107 aa)
polkPolymerase (DNA directed) kappa. (875 aa)
LOC101469640WD repeat and HMG-box DNA binding protein 1. (1134 aa)
ENSMZEP00005020374TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (226 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (896 aa)
rev3lREV3 like, DNA directed polymerase zeta catalytic subunit. (3011 aa)
gins3GINS complex subunit 3. (211 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
ENSMZEP00005022867TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (230 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (899 aa)
piezo1Piezo-type mechanosensitive ion channel component. (2305 aa)
cdt1Chromatin licensing and DNA replication factor 1. (599 aa)
ENSMZEP00005027667Piezo_RRas_bdg domain-containing protein. (571 aa)
ENSMZEP00005027673Uncharacterized protein. (302 aa)
LOC101483840DBF4-type domain-containing protein. (862 aa)
rad17RAD17 checkpoint clamp loader component. (630 aa)
pola1DNA polymerase. (1482 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
MCMDC2Minichromosome maintenance domain containing 2. (635 aa)
rev1REV1 DNA directed polymerase. (1390 aa)
timelessTimeless circadian clock. (1249 aa)
dbf4DBF4 zinc finger. (613 aa)
mcm3DNA helicase; Belongs to the MCM family. (811 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa)
rfc1Replication factor C subunit 1. (1161 aa)
LOC101485137AAA domain-containing protein. (853 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa)
lig1DNA ligase. (1013 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC112434231TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (311 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
ENSMZEP00005034360Uncharacterized protein. (304 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
LOC101476670DNA helicase; Belongs to the MCM family. (828 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (868 aa)
polhPolymerase (DNA directed), eta. (737 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1169 aa)
Your Current Organism:
Maylandia zebra
NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna
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