(24 nodes) Phosphotyrosine residue binding, and GRB2-associated-binding protein 1-4-like network (Maylandia zebra)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1249 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (735 aa)
	LOC101478748	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1302 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (655 aa)
	LOC101484535	GRB2 related adaptor protein a. (216 aa)
	LOC101463941	SHC (Src homology 2 domain containing) transforming protein 2. (725 aa)
	LOC101469990	Protein kinase domain-containing protein. (1188 aa)
	gab1	GRB2-associated binding protein 1. (777 aa)
	LOC101478875	Receptor protein-tyrosine kinase. (1206 aa)
	LOC101475115	GRB2 related adaptor protein b. (261 aa)
	ENSMZEP00005016081	Uncharacterized protein. (207 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
	LOC101473405	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1312 aa)
	LOC101464472	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (678 aa)
	LOC101487152	GRB2 related adaptor protein 2b. (227 aa)
	ralgps2	Ral GEF with PH domain and SH3 binding motif 2. (586 aa)
	LOC101473094	PH domain-containing protein. (781 aa)
	SHC3	SHC adaptor protein 3. (657 aa)
	pdgfra	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1460 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (451 aa)
	LOC101477192	Uncharacterized protein. (220 aa)
	gab2	GRB2-associated binding protein 2. (654 aa)
	ENSMZEP00005034838	Uncharacterized protein. (275 aa)
	ENSMZEP00005034854	Uncharacterized protein. (138 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMZEP00005016081	ENSMZEP00005034838	ENSMZEP00005016081	ENSMZEP00005034838	Uncharacterized protein.	Uncharacterized protein.	0.476
ENSMZEP00005016081	ENSMZEP00005034854	ENSMZEP00005016081	ENSMZEP00005034854	Uncharacterized protein.	Uncharacterized protein.	0.476
ENSMZEP00005016081	LOC101464472	ENSMZEP00005016081	ENSMZEP00005023633	Uncharacterized protein.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.532
ENSMZEP00005016081	LOC101469990	ENSMZEP00005016081	ENSMZEP00005012056	Uncharacterized protein.	Protein kinase domain-containing protein.	0.667
ENSMZEP00005016081	LOC101473094	ENSMZEP00005016081	ENSMZEP00005026141	Uncharacterized protein.	PH domain-containing protein.	0.666
ENSMZEP00005016081	LOC101473405	ENSMZEP00005016081	ENSMZEP00005023164	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.599
ENSMZEP00005016081	LOC101475115	ENSMZEP00005016081	ENSMZEP00005015678	Uncharacterized protein.	GRB2 related adaptor protein b.	0.644
ENSMZEP00005016081	LOC101477192	ENSMZEP00005016081	ENSMZEP00005031262	Uncharacterized protein.	Uncharacterized protein.	0.679
ENSMZEP00005016081	LOC101478748	ENSMZEP00005016081	ENSMZEP00005007329	Uncharacterized protein.	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.477
ENSMZEP00005016081	LOC101478875	ENSMZEP00005016081	ENSMZEP00005013443	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.667
ENSMZEP00005016081	LOC101484535	ENSMZEP00005016081	ENSMZEP00005011035	Uncharacterized protein.	GRB2 related adaptor protein a.	0.644
ENSMZEP00005016081	LOC101487152	ENSMZEP00005016081	ENSMZEP00005025712	Uncharacterized protein.	GRB2 related adaptor protein 2b.	0.679
ENSMZEP00005016081	gab1	ENSMZEP00005016081	ENSMZEP00005012560	Uncharacterized protein.	GRB2-associated binding protein 1.	0.666
ENSMZEP00005016081	gab2	ENSMZEP00005016081	ENSMZEP00005032286	Uncharacterized protein.	GRB2-associated binding protein 2.	0.641
ENSMZEP00005016081	pdgfra	ENSMZEP00005016081	ENSMZEP00005027129	Uncharacterized protein.	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.460
ENSMZEP00005016081	pik3r2	ENSMZEP00005016081	ENSMZEP00005004804	Uncharacterized protein.	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	0.532
ENSMZEP00005016081	plcg2	ENSMZEP00005016081	ENSMZEP00005000076	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.599
ENSMZEP00005016081	ptpn11	ENSMZEP00005016081	ENSMZEP00005010769	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.476
ENSMZEP00005016081	ralgps2	ENSMZEP00005016081	ENSMZEP00005026031	Uncharacterized protein.	Ral GEF with PH domain and SH3 binding motif 2.	0.527
ENSMZEP00005034838	ENSMZEP00005016081	ENSMZEP00005034838	ENSMZEP00005016081	Uncharacterized protein.	Uncharacterized protein.	0.476