(49 nodes) Basal transcription factors, and Helicase-like, DEXD box c2 type network (Maylandia zebra)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC101477796	General transcription factor IIH, polypeptide 5. (71 aa)
	LOC101477738	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor. (854 aa)
	LOC101466920	WD_REPEATS_REGION domain-containing protein. (529 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (300 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (525 aa)
	brip1	BRCA1 interacting protein C-terminal helicase 1. (1223 aa)
	gtf2e1	General transcription factor IIE, polypeptide 1, alpha. (439 aa)
	gtf2a2	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
	LOC101467809	TAFH domain-containing protein. (683 aa)
	taf12	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (164 aa)
	LOC101466805	General transcription factor IIH subunit. (392 aa)
	gtf2b	General transcription factor IIB. (318 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	gtf2f2	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (270 aa)
	taf5l	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (600 aa)
	LOC101480906	TAFH domain-containing protein. (1096 aa)
	gtf2a1	General transcription factor IIA, 1. (385 aa)
	gtf2a1l	General transcription factor IIA, 1-like. (438 aa)
	taf7l	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (362 aa)
	taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (940 aa)
	LOC101471057	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1131 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	taf5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (750 aa)
	ENSMZEP00005014012	Uncharacterized protein. (172 aa)
	LOC101471877	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (252 aa)
	tbp	TATA box binding protein. (307 aa)
	gtf2f1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (532 aa)
	polr2i	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (331 aa)
	tbpl1	TBP-like 1. (187 aa)
	taf1	Transcription initiation factor TFIID subunit. (1853 aa)
	taf6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (638 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
	gtf2h5	General transcription factor IIH subunit 5. (71 aa)
	taf10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
	LOC101478385	Si:dkey-219c3.2. (944 aa)
	taf13	TATA-box binding protein associated factor 13. (124 aa)
	taf6l	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (650 aa)
	taf8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (308 aa)
	gtf2e2	General transcription factor IIE, polypeptide 2, beta. (336 aa)
	cdk20	Cyclin-dependent kinase 20. (344 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	LOC101469859	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (247 aa)
	taf2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (1213 aa)
	fbxw12	Si:ch73-142c19.1. (474 aa)
	TAF4	TATA-box binding protein associated factor 4. (859 aa)
	taf11	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (203 aa)
	LOC101467063	TATA box binding protein like 2. (320 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMZEP00005014012	LOC101466805	ENSMZEP00005014012	ENSMZEP00005005411	Uncharacterized protein.	General transcription factor IIH subunit.	0.913
ENSMZEP00005014012	LOC101466920	ENSMZEP00005014012	ENSMZEP00005001581	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.824
ENSMZEP00005014012	LOC101467809	ENSMZEP00005014012	ENSMZEP00005004658	Uncharacterized protein.	TAFH domain-containing protein.	0.810
ENSMZEP00005014012	LOC101469859	ENSMZEP00005014012	ENSMZEP00005033218	Uncharacterized protein.	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.964
ENSMZEP00005014012	LOC101471057	ENSMZEP00005014012	ENSMZEP00005009509	Uncharacterized protein.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.733
ENSMZEP00005014012	LOC101471877	ENSMZEP00005014012	ENSMZEP00005014634	Uncharacterized protein.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.906
ENSMZEP00005014012	LOC101477738	ENSMZEP00005014012	ENSMZEP00005001168	Uncharacterized protein.	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.810
ENSMZEP00005014012	LOC101477796	ENSMZEP00005014012	ENSMZEP00005000192	Uncharacterized protein.	General transcription factor IIH, polypeptide 5.	0.681
ENSMZEP00005014012	LOC101478385	ENSMZEP00005014012	ENSMZEP00005027512	Uncharacterized protein.	Si:dkey-219c3.2.	0.810
ENSMZEP00005014012	LOC101480906	ENSMZEP00005014012	ENSMZEP00005007728	Uncharacterized protein.	TAFH domain-containing protein.	0.810
ENSMZEP00005014012	TAF4	ENSMZEP00005014012	ENSMZEP00005034783	Uncharacterized protein.	TATA-box binding protein associated factor 4.	0.810
ENSMZEP00005014012	brip1	ENSMZEP00005014012	ENSMZEP00005002095	Uncharacterized protein.	BRCA1 interacting protein C-terminal helicase 1.	0.733
ENSMZEP00005014012	ccnh	ENSMZEP00005014012	ENSMZEP00005019333	Uncharacterized protein.	Cyclin H; Belongs to the cyclin family.	0.862
ENSMZEP00005014012	cdk20	ENSMZEP00005014012	ENSMZEP00005032289	Uncharacterized protein.	Cyclin-dependent kinase 20.	0.724
ENSMZEP00005014012	cdk7	ENSMZEP00005014012	ENSMZEP00005022920	Uncharacterized protein.	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily.	0.724
ENSMZEP00005014012	ercc2	ENSMZEP00005014012	ENSMZEP00005032820	Uncharacterized protein.	Excision repair cross-complementation group 2.	0.928
ENSMZEP00005014012	ercc3	ENSMZEP00005014012	ENSMZEP00005006278	Uncharacterized protein.	Excision repair cross-complementation group 3.	0.949
ENSMZEP00005014012	fbxw12	ENSMZEP00005014012	ENSMZEP00005034632	Uncharacterized protein.	Si:ch73-142c19.1.	0.724
ENSMZEP00005014012	gtf2a1	ENSMZEP00005014012	ENSMZEP00005008243	Uncharacterized protein.	General transcription factor IIA, 1.	0.920
ENSMZEP00005014012	gtf2a1l	ENSMZEP00005014012	ENSMZEP00005008377	Uncharacterized protein.	General transcription factor IIA, 1-like.	0.913