(46 nodes) Positive regulation of macroautophagy network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	scoc	Short coiled-coil protein a. (119 aa)
	bnip3	BCL2 interacting protein 3. (189 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (941 aa)
	LOC101482292	Forkhead box A3. (466 aa)
	LOC101469042	FYVE and coiled-coil domain containing 1b. (1484 aa)
	snx7	Sorting nexin 7. (418 aa)
	pink1	PTEN induced kinase 1. (574 aa)
	hspb8	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family. (227 aa)
	pip4k2a	Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a. (443 aa)
	LOC101483179	Si:dkey-181m9.8. (594 aa)
	rnf31	Uncharacterized protein. (1108 aa)
	gpsm1	G protein signaling modulator 1b. (602 aa)
	sesn1	Sestrin 1. (547 aa)
	epm2a	EPM2A glucan phosphatase, laforin. (316 aa)
	snx30	Sorting nexin family member 30. (443 aa)
	ENSMZEP00005021551	Uncharacterized protein. (145 aa)
	LOC101471460	Uncharacterized protein. (1087 aa)
	LOC101473939	TSC complex subunit 1b. (1275 aa)
	ENSMZEP00005019061	Uncharacterized protein. (905 aa)
	ENSMZEP00005019028	Uncharacterized protein. (905 aa)
	rab3gap2	RAB3 GTPase activating protein subunit 2 (non-catalytic). (1368 aa)
	PIP4K2B	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (412 aa)
	wdr45	WD repeat domain 45. (358 aa)
	wdr24	WD repeat domain 24. (788 aa)
	bag3	BCL2 associated athanogene 3. (535 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (715 aa)
	sptlc1	Serine palmitoyltransferase, long chain base subunit 1. (473 aa)
	htt	Huntingtin. (2575 aa)
	LOC101472147	PX domain-containing protein. (435 aa)
	calcoco2	SKICH domain-containing protein. (580 aa)
	LOC101487241	PX domain-containing protein. (433 aa)
	vps13d	Vacuolar protein sorting 13 homolog D. (4298 aa)
	c9orf72	Zgc:100846. (462 aa)
	tsc2	TSC complex subunit 2. (1730 aa)
	LOC101473040	FYVE and coiled-coil domain containing 1a. (1495 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (576 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (987 aa)
	sting1	Transmembrane protein 173. (396 aa)
	LOC101485050	Sestrin 2. (556 aa)
	LOC101466608	Decorin; May affect the rate of fibrils formation. (358 aa)
	LOC101469904	Si:zfos-80g12.1. (432 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1356 aa)
	LOC101474415	Short coiled-coil protein. (112 aa)
	LOC101475642	Zgc:73226. (183 aa)
	lrsam1	Leucine rich repeat and sterile alpha motif containing 1. (737 aa)
	ENSMZEP00005000054	Uncharacterized protein. (243 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMZEP00005000054	bag3	ENSMZEP00005000054	ENSMZEP00005015076	Uncharacterized protein.	BCL2 associated athanogene 3.	0.421
ENSMZEP00005000054	hspb8	ENSMZEP00005000054	ENSMZEP00005029167	Uncharacterized protein.	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.	0.440
ENSMZEP00005000054	pink1	ENSMZEP00005000054	ENSMZEP00005029905	Uncharacterized protein.	PTEN induced kinase 1.	0.514
ENSMZEP00005000054	tsc2	ENSMZEP00005000054	ENSMZEP00005009713	Uncharacterized protein.	TSC complex subunit 2.	0.981
ENSMZEP00005019028	ripk2	ENSMZEP00005019028	ENSMZEP00005008783	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.847
ENSMZEP00005019061	ripk2	ENSMZEP00005019061	ENSMZEP00005008783	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.847
LOC101469042	LOC101473040	ENSMZEP00005031560	ENSMZEP00005009700	FYVE and coiled-coil domain containing 1b.	FYVE and coiled-coil domain containing 1a.	0.903
LOC101469904	LOC101485050	ENSMZEP00005006825	ENSMZEP00005007835	Si:zfos-80g12.1.	Sestrin 2.	0.904
LOC101469904	sesn1	ENSMZEP00005006825	ENSMZEP00005024166	Si:zfos-80g12.1.	Sestrin 1.	0.903
LOC101469904	wdr24	ENSMZEP00005006825	ENSMZEP00005015290	Si:zfos-80g12.1.	WD repeat domain 24.	0.783
LOC101471460	LOC101483179	ENSMZEP00005020937	ENSMZEP00005026625	Uncharacterized protein.	Si:dkey-181m9.8.	0.900
LOC101471460	ripk2	ENSMZEP00005020937	ENSMZEP00005008783	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.928
LOC101471460	rnf31	ENSMZEP00005020937	ENSMZEP00005026226	Uncharacterized protein.	Uncharacterized protein.	0.902
LOC101472147	LOC101487241	ENSMZEP00005012963	ENSMZEP00005010427	PX domain-containing protein.	PX domain-containing protein.	0.901
LOC101472147	snx30	ENSMZEP00005012963	ENSMZEP00005022156	PX domain-containing protein.	Sorting nexin family member 30.	0.861
LOC101472147	snx7	ENSMZEP00005012963	ENSMZEP00005031224	PX domain-containing protein.	Sorting nexin 7.	0.871
LOC101473040	LOC101469042	ENSMZEP00005009700	ENSMZEP00005031560	FYVE and coiled-coil domain containing 1a.	FYVE and coiled-coil domain containing 1b.	0.903
LOC101473939	bag3	ENSMZEP00005020797	ENSMZEP00005015076	TSC complex subunit 1b.	BCL2 associated athanogene 3.	0.421
LOC101473939	hspb8	ENSMZEP00005020797	ENSMZEP00005029167	TSC complex subunit 1b.	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.	0.440
LOC101473939	pink1	ENSMZEP00005020797	ENSMZEP00005029905	TSC complex subunit 1b.	PTEN induced kinase 1.	0.514