STRINGSTRING
kiaa1841 kiaa1841 ctnnbl1 ctnnbl1 LOC101485137 LOC101485137 samhd1 samhd1 ENSMZEP00005035644 ENSMZEP00005035644 ENSMZEP00005035650 ENSMZEP00005035650 LOC112436638 LOC112436638 LOC101467667 LOC101467667 ENSMZEP00005037958 ENSMZEP00005037958 LOC101480102 LOC101480102 rnf8 rnf8 ENSMZEP00005002103 ENSMZEP00005002103 ung ung mcm3ap mcm3ap LOC101481251 LOC101481251 prkdc prkdc atad5 atad5 mlh1 mlh1 ercc1 ercc1 msh3 msh3 pms2 pms2 exosc3 exosc3 msh6 msh6 LOC101467059 LOC101467059 rnf168 rnf168 msh2 msh2 ENSMZEP00005002852 ENSMZEP00005002852 ENSMZEP00005002781 ENSMZEP00005002781 lig4 lig4 ENSMZEP00005002313 ENSMZEP00005002313 batf batf aicda aicda rag2 rag2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kiaa1841Si:ch211-189k9.2. (633 aa)
ctnnbl1Catenin, beta like 1. (577 aa)
LOC101485137AAA domain-containing protein. (853 aa)
samhd1SAM domain and HD domain 1. (622 aa)
ENSMZEP00005035644HD domain-containing protein. (580 aa)
ENSMZEP00005035650HD domain-containing protein. (515 aa)
LOC112436638HD domain-containing protein. (769 aa)
LOC101467667Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like. (515 aa)
ENSMZEP00005037958HD domain-containing protein. (179 aa)
LOC101480102Uncharacterized protein. (237 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (544 aa)
ENSMZEP00005002103Uncharacterized protein. (551 aa)
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (301 aa)
mcm3apMinichromosome maintenance complex component 3 associated protein. (2193 aa)
LOC101481251X-ray repair complementing defective repair in Chinese hamster cells 4. (335 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4055 aa)
atad5ATPase family AAA domain containing 5a. (1807 aa)
mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (735 aa)
ercc1Excision repair cross-complementation group 1. (352 aa)
msh3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1115 aa)
pms2PMS1 homolog 2, mismatch repair system component. (892 aa)
exosc3Exosome component 3. (244 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1379 aa)
LOC101467059CD40 ligand; Belongs to the tumor necrosis factor family. (231 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (430 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
ENSMZEP00005002852HD domain-containing protein. (188 aa)
ENSMZEP00005002781HD domain-containing protein. (576 aa)
lig4DNA ligase. (910 aa)
ENSMZEP00005002313HD domain-containing protein. (703 aa)
batfBasic leucine zipper transcription factor, ATF-like. (123 aa)
aicdaActivation-induced cytidine deaminase. (210 aa)
rag2Recombination activating gene 2. (533 aa)
Your Current Organism:
Maylandia zebra
NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.