(59 nodes) Regulation of telomere maintenance network (Maylandia zebra)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	dcp2	Decapping mRNA 2. (391 aa)
	LOC101485547	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa)
	LOC106674744	Poly [ADP-ribose] polymerase. (1029 aa)
	LOC101484939	NIMA-related kinase 2. (440 aa)
	NEK2	NIMA-related kinase 2. (370 aa)
	LOC101474062	Poly [ADP-ribose] polymerase. (1075 aa)
	sirt6	Sirtuin 6. (351 aa)
	smg6	SMG6 nonsense mediated mRNA decay factor. (1647 aa)
	smg1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3645 aa)
	pot1	Protection of telomeres 1 homolog. (669 aa)
	cct5	Chaperonin containing TCP1, subunit 5 (epsilon). (541 aa)
	LOC101487465	TERF1 (TRF1)-interacting nuclear factor 2. (580 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (535 aa)
	mcrs1	Microspherule protein 1. (466 aa)
	nat10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1035 aa)
	ino80d	INO80 complex subunit Da. (957 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1727 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2554 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1064 aa)
	ten1	TEN1 subunit of CST complex. (130 aa)
	LOC101478239	Poly [ADP-ribose] polymerase. (1263 aa)
	nfrkb	Nuclear factor related to kappaB binding protein. (1306 aa)
	ino80e	INO80 complex subunit E. (236 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (423 aa)
	ppp1r10	Protein phosphatase 1, regulatory subunit 10. (807 aa)
	LOC101473061	Poly [ADP-ribose] polymerase. (1281 aa)
	ENSMZEP00005022073	SMG5 nonsense mediated mRNA decay factor. (642 aa)
	ylpm1	YLP motif containing 1. (1664 aa)
	tfpt	TCF3 (E2A) fusion partner. (199 aa)
	LOC101478306	Uncharacterized protein. (496 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (723 aa)
	ercc4	Excision repair cross-complementation group 4. (899 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (374 aa)
	LOC101471057	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1131 aa)
	LOC101467053	SMG5 nonsense mediated mRNA decay factor. (1012 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	dkc1	Dyskeratosis congenita 1, dyskerin. (500 aa)
	ENSMZEP00005019048	Uncharacterized protein. (255 aa)
	ENSMZEP00005019039	AAA_23 domain-containing protein. (53 aa)
	ENSMZEP00005018680	Uncharacterized protein. (1708 aa)
	exosc10	Exosome component 10. (890 aa)
	ino80	INO80 complex ATPase subunit. (1506 aa)
	Atm	Uncharacterized protein. (139 aa)
	ENSMZEP00005016530	TAN domain-containing protein. (177 aa)
	cct3	T-complex protein 1 subunit gamma. (540 aa)
	atrx	ATRX chromatin remodeler. (1680 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (566 aa)
	LOC101487114	HTH myb-type domain-containing protein. (706 aa)
	terf2	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (509 aa)
	ercc1	Excision repair cross-complementation group 1. (352 aa)
	ccdc174	Coiled-coil domain containing 174. (544 aa)
	ENSMZEP00005012187	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (691 aa)
	fbxo4	F-box protein 4. (396 aa)
	naf1	Uncharacterized protein. (397 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (602 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1581 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSMZEP00005012187	ENSMZEP00005016548	ENSMZEP00005012187	Uncharacterized protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.806
Atm	ENSMZEP00005016530	ENSMZEP00005016548	ENSMZEP00005016530	Uncharacterized protein.	TAN domain-containing protein.	0.689
Atm	ENSMZEP00005018680	ENSMZEP00005016548	ENSMZEP00005018680	Uncharacterized protein.	Uncharacterized protein.	0.449
Atm	ENSMZEP00005019039	ENSMZEP00005016548	ENSMZEP00005019039	Uncharacterized protein.	AAA_23 domain-containing protein.	0.857
Atm	ENSMZEP00005019048	ENSMZEP00005016548	ENSMZEP00005019048	Uncharacterized protein.	Uncharacterized protein.	0.857
Atm	LOC101471057	ENSMZEP00005016548	ENSMZEP00005009509	Uncharacterized protein.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.709
Atm	LOC101485547	ENSMZEP00005016548	ENSMZEP00005012090	Uncharacterized protein.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.653
Atm	atr	ENSMZEP00005016548	ENSMZEP00005004204	Uncharacterized protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.997
Atm	atrx	ENSMZEP00005016548	ENSMZEP00005015462	Uncharacterized protein.	ATRX chromatin remodeler.	0.449
Atm	ercc1	ENSMZEP00005016548	ENSMZEP00005012840	Uncharacterized protein.	Excision repair cross-complementation group 1.	0.625
Atm	ercc4	ENSMZEP00005016548	ENSMZEP00005009673	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.664
Atm	rad50	ENSMZEP00005016548	ENSMZEP00005003251	Uncharacterized protein.	RAD50 homolog, double strand break repair protein.	0.985
Atm	slx4	ENSMZEP00005016548	ENSMZEP00005004897	Uncharacterized protein.	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae).	0.633
Atm	smg1	ENSMZEP00005016548	ENSMZEP00005030489	Uncharacterized protein.	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.641
Atm	uchl5	ENSMZEP00005016548	ENSMZEP00005020991	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.428
Atm	xrcc1	ENSMZEP00005016548	ENSMZEP00005010028	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.434
Atm	xrcc5	ENSMZEP00005016548	ENSMZEP00005010017	Uncharacterized protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.806
ENSMZEP00005012187	Atm	ENSMZEP00005012187	ENSMZEP00005016548	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	Uncharacterized protein.	0.806
ENSMZEP00005012187	ENSMZEP00005016530	ENSMZEP00005012187	ENSMZEP00005016530	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	TAN domain-containing protein.	0.806
ENSMZEP00005012187	ENSMZEP00005019039	ENSMZEP00005012187	ENSMZEP00005019039	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	AAA_23 domain-containing protein.	0.686