(42 nodes) Cellular response to amino acid starvation network (Maylandia zebra)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	rragc	Ras-related GTP binding Ca. (382 aa)
	ENSMZEP00005025583	Uncharacterized protein. (152 aa)
	sesn1	Sestrin 1. (547 aa)
	LOC101470757	Ras-related GTP binding D. (416 aa)
	LOC101487601	Si:ch211-153j24.3. (391 aa)
	flcn	Folliculin. (556 aa)
	mios	Missing oocyte, meiosis regulator, homolog (Drosophila). (884 aa)
	LOC101477082	Ras-related GTP binding A. (315 aa)
	nprl2	NPR2 like, GATOR1 complex subunit. (386 aa)
	atf3	Activating transcription factor 3. (208 aa)
	wdr24	WD repeat domain 24. (788 aa)
	bmt2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (392 aa)
	ENSMZEP00005014744	CBM21 domain-containing protein. (251 aa)
	ENSMZEP00005013099	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (266 aa)
	LOC101480601	Eukaryotic translation initiation factor 2-alpha kinase 2. (649 aa)
	LOC101480319	Uncharacterized protein. (600 aa)
	LOC101480895	Uncharacterized protein. (867 aa)
	DAPL1	Death associated protein like 1. (116 aa)
	rnf152	Ring finger protein 152. (165 aa)
	atf4	Activating transcription factor 4a. (438 aa)
	LOC101485050	Sestrin 2. (556 aa)
	LOC101469904	Si:zfos-80g12.1. (432 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	Szt2	Uncharacterized protein. (183 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (2310 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1100 aa)
	gcn1	GCN1 activator of EIF2AK4. (2623 aa)
	lars1	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family. (1184 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (433 aa)
	tfeb	Transcription factor EB. (516 aa)
	wdr59	WD repeat domain 59. (973 aa)
	LOC101463633	Uncharacterized protein. (341 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1423 aa)
	Eif2ak4	RWD domain-containing protein. (141 aa)
	LOC101480084	Uncharacterized protein. (381 aa)
	seh1l	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (367 aa)
	kptn	Kaptin (actin binding protein). (435 aa)
	nprl3	NPR3-like, GATOR1 complex subunit. (608 aa)
	dap	Death-associated protein. (104 aa)
	lg17h12orf66	Si:ch211-125a15.1. (448 aa)
	impact	Impact RWD domain protein. (319 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	Eif2ak4	ENSMZEP00005036196	ENSMZEP00005036195	Eukaryotic translation initiation factor 2 alpha kinase 4.	RWD domain-containing protein.	0.864
EIF2AK4	LOC101477082	ENSMZEP00005036196	ENSMZEP00005020103	Eukaryotic translation initiation factor 2 alpha kinase 4.	Ras-related GTP binding A.	0.408
EIF2AK4	atf4	ENSMZEP00005036196	ENSMZEP00005008179	Eukaryotic translation initiation factor 2 alpha kinase 4.	Activating transcription factor 4a.	0.467
EIF2AK4	eif2ak3	ENSMZEP00005036196	ENSMZEP00005004276	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.505
EIF2AK4	eif2s1	ENSMZEP00005036196	ENSMZEP00005001845	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.934
EIF2AK4	gcn1	ENSMZEP00005036196	ENSMZEP00005003973	Eukaryotic translation initiation factor 2 alpha kinase 4.	GCN1 activator of EIF2AK4.	0.808
EIF2AK4	impact	ENSMZEP00005036196	ENSMZEP00005026839	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.426
EIF2AK4	lars1	ENSMZEP00005036196	ENSMZEP00005003527	Eukaryotic translation initiation factor 2 alpha kinase 4.	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.551
EIF2AK4	mtor	ENSMZEP00005036196	ENSMZEP00005006208	Eukaryotic translation initiation factor 2 alpha kinase 4.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.563
ENSMZEP00005013099	LOC101480319	ENSMZEP00005013099	ENSMZEP00005013033	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.903
ENSMZEP00005013099	LOC101480895	ENSMZEP00005013099	ENSMZEP00005012972	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.902
ENSMZEP00005013099	eif2s1	ENSMZEP00005013099	ENSMZEP00005001845	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.987
ENSMZEP00005014744	ENSMZEP00005025583	ENSMZEP00005014744	ENSMZEP00005025583	CBM21 domain-containing protein.	Uncharacterized protein.	0.728
ENSMZEP00005014744	LOC101477082	ENSMZEP00005014744	ENSMZEP00005020103	CBM21 domain-containing protein.	Ras-related GTP binding A.	0.516
ENSMZEP00005014744	SZT2	ENSMZEP00005014744	ENSMZEP00005004572	CBM21 domain-containing protein.	SZT2 subunit of KICSTOR complex.	0.669
ENSMZEP00005014744	itfg2	ENSMZEP00005014744	ENSMZEP00005001327	CBM21 domain-containing protein.	Integrin alpha FG-GAP repeat containing 2.	0.740
ENSMZEP00005014744	kptn	ENSMZEP00005014744	ENSMZEP00005031337	CBM21 domain-containing protein.	Kaptin (actin binding protein).	0.654
ENSMZEP00005014744	lg17h12orf66	ENSMZEP00005014744	ENSMZEP00005028962	CBM21 domain-containing protein.	Si:ch211-125a15.1.	0.759
ENSMZEP00005014744	mtor	ENSMZEP00005014744	ENSMZEP00005006208	CBM21 domain-containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.494
ENSMZEP00005014744	nprl2	ENSMZEP00005014744	ENSMZEP00005019630	CBM21 domain-containing protein.	NPR2 like, GATOR1 complex subunit.	0.679