(18 nodes) miRNA-mediated gene silencing by inhibition of translation network (Maylandia zebra)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	LOC101480651	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (870 aa)
	ENSMZEP00005012266	Uncharacterized protein. (164 aa)
	LOC101465200	Trinucleotide repeat containing adaptor 6C1. (1815 aa)
	trim71	Tripartite motif containing 71, E3 ubiquitin protein ligase. (834 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (955 aa)
	ENSMZEP00005025843	Uncharacterized protein. (1501 aa)
	ENSMZEP00005025871	TNRC6-PABC_bdg domain-containing protein. (378 aa)
	LOC101482087	Trinucleotide repeat containing adaptor 6C2. (1858 aa)
	ddx6	DEAD (Asp-Glu-Ala-Asp) box helicase 6; Belongs to the DEAD box helicase family. (481 aa)
	LOC101469049	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (867 aa)
	LOC101472794	Uncharacterized protein; Belongs to the DEAD box helicase family. (487 aa)
	ENSMZEP00005037770	Uncharacterized protein. (147 aa)
	LOC101466128	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (944 aa)
	LOC101488107	DEAD (Asp-Glu-Ala-Asp) box helicase 61; Belongs to the DEAD box helicase family. (477 aa)
	LOC101464537	Si:dkey-217f16.6. (1751 aa)
	tnrc6a	Trinucleotide repeat containing adaptor 6A. (1840 aa)
	LOC101466533	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (860 aa)
	LOC101466039	Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF4ENIF1	LOC101472794	ENSMZEP00005021390	ENSMZEP00005035144	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.923
EIF4ENIF1	LOC101488107	ENSMZEP00005021390	ENSMZEP00005004608	Eukaryotic translation initiation factor 4E nuclear import factor 1.	DEAD (Asp-Glu-Ala-Asp) box helicase 61; Belongs to the DEAD box helicase family.	0.923
EIF4ENIF1	ddx6	ENSMZEP00005021390	ENSMZEP00005032346	Eukaryotic translation initiation factor 4E nuclear import factor 1.	DEAD (Asp-Glu-Ala-Asp) box helicase 6; Belongs to the DEAD box helicase family.	0.923
ENSMZEP00005025843	ENSMZEP00005025871	ENSMZEP00005025843	ENSMZEP00005025871	Uncharacterized protein.	TNRC6-PABC_bdg domain-containing protein.	0.870
ENSMZEP00005025843	LOC101466039	ENSMZEP00005025843	ENSMZEP00005010653	Uncharacterized protein.	Argonaute RISC component 1; Belongs to the argonaute family.	0.492
ENSMZEP00005025843	LOC101466128	ENSMZEP00005025843	ENSMZEP00005035247	Uncharacterized protein.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
ENSMZEP00005025843	LOC101466533	ENSMZEP00005025843	ENSMZEP00005010565	Uncharacterized protein.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
ENSMZEP00005025843	LOC101469049	ENSMZEP00005025843	ENSMZEP00005035092	Uncharacterized protein.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
ENSMZEP00005025843	LOC101480651	ENSMZEP00005025843	ENSMZEP00005012024	Uncharacterized protein.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.492
ENSMZEP00005025871	ENSMZEP00005025843	ENSMZEP00005025871	ENSMZEP00005025843	TNRC6-PABC_bdg domain-containing protein.	Uncharacterized protein.	0.870
ENSMZEP00005025871	LOC101466039	ENSMZEP00005025871	ENSMZEP00005010653	TNRC6-PABC_bdg domain-containing protein.	Argonaute RISC component 1; Belongs to the argonaute family.	0.492
ENSMZEP00005025871	LOC101466128	ENSMZEP00005025871	ENSMZEP00005035247	TNRC6-PABC_bdg domain-containing protein.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
ENSMZEP00005025871	LOC101466533	ENSMZEP00005025871	ENSMZEP00005010565	TNRC6-PABC_bdg domain-containing protein.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
ENSMZEP00005025871	LOC101469049	ENSMZEP00005025871	ENSMZEP00005035092	TNRC6-PABC_bdg domain-containing protein.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
ENSMZEP00005025871	LOC101480651	ENSMZEP00005025871	ENSMZEP00005012024	TNRC6-PABC_bdg domain-containing protein.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.492
LOC101464537	LOC101466039	ENSMZEP00005007669	ENSMZEP00005010653	Si:dkey-217f16.6.	Argonaute RISC component 1; Belongs to the argonaute family.	0.492
LOC101464537	LOC101466128	ENSMZEP00005007669	ENSMZEP00005035247	Si:dkey-217f16.6.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
LOC101464537	LOC101466533	ENSMZEP00005007669	ENSMZEP00005010565	Si:dkey-217f16.6.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
LOC101464537	LOC101469049	ENSMZEP00005007669	ENSMZEP00005035092	Si:dkey-217f16.6.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.492
LOC101464537	LOC101480651	ENSMZEP00005007669	ENSMZEP00005012024	Si:dkey-217f16.6.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.492