(37 nodes) Homologous recombination network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (423 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1547 aa)
	ankle1	Uncharacterized protein. (1145 aa)
	hsf2bp	Heat shock transcription factor 2 binding protein. (341 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (620 aa)
	msh4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (871 aa)
	ccnb1ip1	Cyclin B1 interacting protein 1. (265 aa)
	psmc3ip	PSMC3 interacting protein. (212 aa)
	spo11	SPO11 initiator of meiotic double stranded breaks. (390 aa)
	LOC101466600	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (679 aa)
	LOC101472995	RAD51 paralog C. (359 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (550 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1727 aa)
	ENSMZEP00005005940	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (517 aa)
	fancm	Uncharacterized protein. (2085 aa)
	ENSMZEP00005006159	Helicase for meiosis 1. (1036 aa)
	ENSMZEP00005006362	Uncharacterized protein. (89 aa)
	msh5	MutS homolog 5. (530 aa)
	LOC101474223	Uncharacterized protein. (901 aa)
	tex11	Testis expressed 11. (813 aa)
	dmc1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (338 aa)
	ercc4	Excision repair cross-complementation group 4. (899 aa)
	meiob	Methionine sulfoxide reductase B1b. (459 aa)
	syce3	Zgc:194246. (97 aa)
	hdac10	Histone deacetylase 10. (673 aa)
	C1orf146	Chromosome 1 open reading frame 146. (183 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1509 aa)
	fancd2	FA complementation group D2. (1425 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (735 aa)
	mnd1	Meiotic nuclear divisions 1 homolog (S. cerevisiae). (218 aa)
	rad51d	RAD51 paralog D. (333 aa)
	EME2	ERCC4 domain-containing protein. (431 aa)
	rnf212b	Uncharacterized protein. (221 aa)
	cenpx	Centromere protein X. (81 aa)
	ENSMZEP00005019039	AAA_23 domain-containing protein. (53 aa)
	ENSMZEP00005019048	Uncharacterized protein. (255 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf146	ENSMZEP00005006159	ENSMZEP00005013132	ENSMZEP00005006159	Chromosome 1 open reading frame 146.	Helicase for meiosis 1.	0.585
C1orf146	msh4	ENSMZEP00005013132	ENSMZEP00005027614	Chromosome 1 open reading frame 146.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.574
C1orf146	tex11	ENSMZEP00005013132	ENSMZEP00005007434	Chromosome 1 open reading frame 146.	Testis expressed 11.	0.469
EME2	ENSMZEP00005005940	ENSMZEP00005015567	ENSMZEP00005005940	ERCC4 domain-containing protein.	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	0.458
EME2	ENSMZEP00005019039	ENSMZEP00005015567	ENSMZEP00005019039	ERCC4 domain-containing protein.	AAA_23 domain-containing protein.	0.409
EME2	ENSMZEP00005019048	ENSMZEP00005015567	ENSMZEP00005019048	ERCC4 domain-containing protein.	Uncharacterized protein.	0.409
EME2	LOC101466600	ENSMZEP00005015567	ENSMZEP00005035030	ERCC4 domain-containing protein.	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	0.458
EME2	LOC101472995	ENSMZEP00005015567	ENSMZEP00005035822	ERCC4 domain-containing protein.	RAD51 paralog C.	0.485
EME2	eme1	ENSMZEP00005015567	ENSMZEP00005004373	ERCC4 domain-containing protein.	Essential meiotic structure-specific endonuclease 1.	0.797
EME2	ercc4	ENSMZEP00005015567	ENSMZEP00005009673	ERCC4 domain-containing protein.	Excision repair cross-complementation group 4.	0.718
EME2	fancd2	ENSMZEP00005015567	ENSMZEP00005013860	ERCC4 domain-containing protein.	FA complementation group D2.	0.439
EME2	fancm	ENSMZEP00005015567	ENSMZEP00005006038	ERCC4 domain-containing protein.	Uncharacterized protein.	0.631
EME2	mus81	ENSMZEP00005015567	ENSMZEP00005026575	ERCC4 domain-containing protein.	MUS81 structure-specific endonuclease subunit.	0.991
EME2	rad50	ENSMZEP00005015567	ENSMZEP00005003251	ERCC4 domain-containing protein.	RAD50 homolog, double strand break repair protein.	0.409
EME2	rad51d	ENSMZEP00005015567	ENSMZEP00005015332	ERCC4 domain-containing protein.	RAD51 paralog D.	0.436
EME2	slx4	ENSMZEP00005015567	ENSMZEP00005004897	ERCC4 domain-containing protein.	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae).	0.606
ENSMZEP00005005940	EME2	ENSMZEP00005005940	ENSMZEP00005015567	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	ERCC4 domain-containing protein.	0.458
ENSMZEP00005005940	ENSMZEP00005019039	ENSMZEP00005005940	ENSMZEP00005019039	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	AAA_23 domain-containing protein.	0.632
ENSMZEP00005005940	ENSMZEP00005019048	ENSMZEP00005005940	ENSMZEP00005019048	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	Uncharacterized protein.	0.632
ENSMZEP00005005940	LOC101472995	ENSMZEP00005005940	ENSMZEP00005035822	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	RAD51 paralog C.	0.755