STRINGSTRING
rnf169 rnf169 pnkp pnkp ENSMZEP00005002103 ENSMZEP00005002103 LOC101480102 LOC101480102 ENSMZEP00005037958 ENSMZEP00005037958 wrap53 wrap53 rad50 rad50 rnf168 rnf168 shld2 shld2 paxx paxx LOC101483411 LOC101483411 ARPC4 ARPC4 rnf8 rnf8 smchd1 smchd1 rec114 rec114 sirt7 sirt7 poll poll LOC101470671 LOC101470671 LOC101468546 LOC101468546 parp3 parp3 rad18 rad18 LOC101485066 LOC101485066 polh polh actr2 actr2 LOC101467667 LOC101467667 LOC112436638 LOC112436638 ENSMZEP00005035650 ENSMZEP00005035650 ENSMZEP00005035644 ENSMZEP00005035644 samhd1 samhd1 LOC101482018 LOC101482018 sirt6 sirt6 timeless timeless arpc2 arpc2 rif1 rif1 LOC101481337 LOC101481337 hus1 hus1 Rbbp8 Rbbp8 LOC101476876 LOC101476876 ENSMZEP00005019048 ENSMZEP00005019048 ENSMZEP00005019039 ENSMZEP00005019039 LOC101475383 LOC101475383 ufl1 ufl1 tp53bp1 tp53bp1 LOC112430055 LOC112430055 parp1 parp1 vcp vcp arpc3 arpc3 rpa3 rpa3 WDR70 WDR70 mre11 mre11 LOC101481251 LOC101481251 rad51 rad51 LOC101467416 LOC101467416 prpf19 prpf19 Aplf Aplf slf1 slf1 ddb1 ddb1 smarcad1 smarcad1 LOC101472281 LOC101472281 ENSMZEP00005002852 ENSMZEP00005002852 ENSMZEP00005002781 ENSMZEP00005002781 ENSMZEP00005002313 ENSMZEP00005002313
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rnf169Ring finger protein 169. (585 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (602 aa)
ENSMZEP00005002103Uncharacterized protein. (551 aa)
LOC101480102Uncharacterized protein. (237 aa)
ENSMZEP00005037958HD domain-containing protein. (179 aa)
wrap53WD repeat containing, antisense to TP53. (544 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (430 aa)
shld2Si:ch211-134m17.9. (914 aa)
paxxUncharacterized protein. (259 aa)
LOC101483411Zgc:136908; Belongs to the AAA ATPase family. (806 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (204 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (544 aa)
smchd1Structural maintenance of chromosomes flexible hinge domain containing 1. (1546 aa)
rec114REC114 meiotic recombination protein. (223 aa)
sirt7Sirtuin 7. (405 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (564 aa)
LOC101470671SET domain and mariner transposase fusion gene. (294 aa)
LOC101468546Actin related protein 2/3 complex, subunit 4. (228 aa)
parp3Poly [ADP-ribose] polymerase. (532 aa)
rad18RAD18 E3 ubiquitin protein ligase. (530 aa)
LOC101485066Uncharacterized protein. (1318 aa)
polhPolymerase (DNA directed), eta. (737 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
LOC101467667Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like. (515 aa)
LOC112436638HD domain-containing protein. (769 aa)
ENSMZEP00005035650HD domain-containing protein. (515 aa)
ENSMZEP00005035644HD domain-containing protein. (580 aa)
samhd1SAM domain and HD domain 1. (622 aa)
LOC101482018Mab-21 domain-containing protein. (481 aa)
sirt6Sirtuin 6. (351 aa)
timelessTimeless circadian clock. (1249 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
rif1Replication timing regulatory factor 1. (2240 aa)
LOC101481337Zgc:101810; Belongs to the actin family. (394 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
Rbbp8SAE2 domain-containing protein. (75 aa)
LOC101476876Actin related protein 3B; Belongs to the actin family. (418 aa)
ENSMZEP00005019048Uncharacterized protein. (255 aa)
ENSMZEP00005019039AAA_23 domain-containing protein. (53 aa)
LOC101475383Uncharacterized protein; Belongs to the actin family. (418 aa)
ufl1UFM1-specific ligase 1. (788 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1709 aa)
LOC112430055Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (658 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
vcpValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
rpa3Replication protein A3. (122 aa)
WDR70WD repeat domain 70. (658 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (608 aa)
LOC101481251X-ray repair complementing defective repair in Chinese hamster cells 4. (335 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
LOC101467416Actin related protein 3; Belongs to the actin family. (459 aa)
prpf19Pre-mRNA processing factor 19. (505 aa)
AplfUncharacterized protein. (32 aa)
slf1SMC5-SMC6 complex localization factor 1. (885 aa)
ddb1Damage-specific DNA binding protein 1. (1140 aa)
smarcad1Uncharacterized protein. (1021 aa)
LOC101472281Tonsoku-like, DNA repair protein. (1445 aa)
ENSMZEP00005002852HD domain-containing protein. (188 aa)
ENSMZEP00005002781HD domain-containing protein. (576 aa)
ENSMZEP00005002313HD domain-containing protein. (703 aa)
Your Current Organism:
Maylandia zebra
NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna
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