(80 nodes) Regulation of myeloid cell differentiation network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPS19	Ribosomal protein S19. (152 aa)
	LOC101477807	BHLH domain-containing protein. (518 aa)
	LOC101472162	Zgc:158254. (503 aa)
	ENSMZEP00005028092	SAP domain-containing protein. (140 aa)
	acin1	Uncharacterized protein. (512 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (256 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (265 aa)
	lef1	Lymphoid enhancer-binding factor 1. (361 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (634 aa)
	LOC101463758	Tescalcin b. (216 aa)
	LOC101464216	Uncharacterized protein. (465 aa)
	LOC101469924	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	LOC101471066	C1q domain-containing protein. (241 aa)
	rb1	Retinoblastoma 1. (912 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1752 aa)
	LOC112435008	Transmembrane protein 178A. (330 aa)
	LOC101468140	Meis homeobox 2b. (383 aa)
	ctr9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1158 aa)
	tesc	Tescalcin a. (226 aa)
	ENSMZEP00005018027	Uncharacterized protein; Belongs to the peptidase C14A family. (287 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	LOC101473504	Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum). (452 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (452 aa)
	LOC101483657	G protein-coupled receptor 137Bb. (377 aa)
	LOC101464894	Meis homeobox 1 b. (470 aa)
	LOC101464651	SAP domain-containing protein. (1652 aa)
	ENSMZEP00005037176	Uncharacterized protein; Belongs to the peptidase C14A family. (330 aa)
	LOC101476034	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (766 aa)
	mturn	Maturin, neural progenitor differentiation regulator homolog (Xenopus). (129 aa)
	LOC112430089	Uncharacterized protein; Belongs to the peptidase C14A family. (483 aa)
	ENSMZEP00005014658	Uncharacterized protein; Belongs to the peptidase C14A family. (347 aa)
	ENSMZEP00005014631	CARD domain-containing protein. (140 aa)
	ENSMZEP00005014620	Uncharacterized protein; Belongs to the peptidase C14A family. (203 aa)
	ENSMZEP00005014574	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (493 aa)
	ENSMZEP00005014492	Interleukin 34. (208 aa)
	ENSMZEP00005014476	Uncharacterized protein; Belongs to the peptidase C14A family. (239 aa)
	ENSMZEP00005014450	Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (268 aa)
	ENSMZEP00005014439	CARD domain-containing protein. (201 aa)
	lrrc17	Leucine rich repeat containing 17. (452 aa)
	LOC101488014	Transcription factor binding to IGHM enhancer 3b. (451 aa)
	LOC101485806	GATA binding protein 1a. (424 aa)
	fstl3	Follistatin-like 3 (secreted glycoprotein). (250 aa)
	cldn18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (255 aa)
	faxdc2	Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (342 aa)
	mitfa	Melanocyte inducing transcription factor a. (473 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1086 aa)
	LOC101487119	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (347 aa)
	med12	Mediator complex subunit 12. (2076 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (671 aa)
	cnot4	CCR4-NOT transcription complex, subunit 4a. (797 aa)
	fam210b	Family with sequence similarity 210 member B. (304 aa)
	LOC101464752	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (305 aa)
	LOC101487438	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (244 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	hspa9	Heat shock protein 9; Belongs to the heat shock protein 70 family. (677 aa)
	LOC101470036	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (473 aa)
	tmem64	Transmembrane protein 64. (352 aa)
	ankrd54	Ankyrin repeat domain 54. (317 aa)
	LOC101467688	Ribosomal protein S19. (146 aa)
	meis2	Meis homeobox 2a. (480 aa)
	LOC101479353	Uncharacterized protein. (955 aa)
	ENSMZEP00005002786	Uncharacterized protein. (822 aa)
	nf1	Neurofibromin 1b. (2713 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (310 aa)
	TMEM178A	Transmembrane protein 178A. (330 aa)
	gabpa	GA binding protein transcription factor subunit alpha. (441 aa)
	LOC101471162	Uncharacterized protein. (264 aa)
	Gata1	Uncharacterized protein. (246 aa)
	LOC101473892	Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
	LOC101464177	G protein-coupled receptor 171. (377 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (678 aa)
	TNFRSF11B	TNF receptor superfamily member 11b. (418 aa)
	il34	Interleukin 34. (288 aa)
	pithd1	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1. (207 aa)
	LOC106674852	Uncharacterized protein; Belongs to the peptidase C14A family. (354 aa)
	LOC101475706	Uncharacterized protein; Belongs to the peptidase C14A family. (483 aa)
	mitfb	BHLH domain-containing protein. (513 aa)
	LOC101485975	CCAAT enhancer binding protein beta. (292 aa)
	hax1	HCLS1 associated protein X-1. (297 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCSTAMP	tnfsf11	ENSMZEP00005016403	ENSMZEP00005028011	Dendrocyte expressed seven transmembrane protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.576
ENSMZEP00005014439	LOC101469924	ENSMZEP00005014439	ENSMZEP00005023226	CARD domain-containing protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.617
ENSMZEP00005014439	ripk1	ENSMZEP00005014439	ENSMZEP00005033604	CARD domain-containing protein.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.797
ENSMZEP00005014450	LOC101469924	ENSMZEP00005014450	ENSMZEP00005023226	Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Tumor necrosis factor b (TNF superfamily, member 2).	0.617
ENSMZEP00005014450	ripk1	ENSMZEP00005014450	ENSMZEP00005033604	Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.797
ENSMZEP00005014476	LOC101469924	ENSMZEP00005014476	ENSMZEP00005023226	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor b (TNF superfamily, member 2).	0.731
ENSMZEP00005014476	LOC101475706	ENSMZEP00005014476	ENSMZEP00005034964	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.902
ENSMZEP00005014476	LOC112430089	ENSMZEP00005014476	ENSMZEP00005014703	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.902
ENSMZEP00005014476	ripk1	ENSMZEP00005014476	ENSMZEP00005033604	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.981
ENSMZEP00005014492	LOC101471162	ENSMZEP00005014492	ENSMZEP00005031830	Interleukin 34.	Uncharacterized protein.	0.848
ENSMZEP00005014574	LOC101469924	ENSMZEP00005014574	ENSMZEP00005023226	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Tumor necrosis factor b (TNF superfamily, member 2).	0.731
ENSMZEP00005014574	ripk1	ENSMZEP00005014574	ENSMZEP00005033604	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.822
ENSMZEP00005014620	LOC101469924	ENSMZEP00005014620	ENSMZEP00005023226	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor b (TNF superfamily, member 2).	0.617
ENSMZEP00005014620	ripk1	ENSMZEP00005014620	ENSMZEP00005033604	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.797
ENSMZEP00005014631	LOC101469924	ENSMZEP00005014631	ENSMZEP00005023226	CARD domain-containing protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.617
ENSMZEP00005014631	ripk1	ENSMZEP00005014631	ENSMZEP00005033604	CARD domain-containing protein.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.797
ENSMZEP00005014658	LOC101469924	ENSMZEP00005014658	ENSMZEP00005023226	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor b (TNF superfamily, member 2).	0.617
ENSMZEP00005014658	ripk1	ENSMZEP00005014658	ENSMZEP00005033604	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.797
ENSMZEP00005018027	LOC101469924	ENSMZEP00005018027	ENSMZEP00005023226	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor b (TNF superfamily, member 2).	0.617
ENSMZEP00005018027	ripk1	ENSMZEP00005018027	ENSMZEP00005033604	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.797