(69 nodes) Negative regulation of DNA recombination network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112431686	H15 domain-containing protein. (152 aa)
	ENSMZEP00005019890	H15 domain-containing protein. (184 aa)
	ENSMZEP00005019675	H15 domain-containing protein. (177 aa)
	ENSMZEP00005019564	H15 domain-containing protein. (143 aa)
	ENSMZEP00005018931	H15 domain-containing protein. (159 aa)
	ENSMZEP00005018657	H15 domain-containing protein. (197 aa)
	terf2ip	Uncharacterized protein. (617 aa)
	ENSMZEP00005017180	H15 domain-containing protein. (244 aa)
	ENSMZEP00005016503	H15 domain-containing protein. (138 aa)
	LOC112430459	H15 domain-containing protein. (186 aa)
	LOC101467513	H1 histone family, member 0. (197 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (735 aa)
	ENSMZEP00005014486	H15 domain-containing protein. (142 aa)
	parp3	Poly [ADP-ribose] polymerase. (532 aa)
	LOC101487114	HTH myb-type domain-containing protein. (706 aa)
	terf2	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (509 aa)
	ENSMZEP00005012716	H15 domain-containing protein. (131 aa)
	msh3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1115 aa)
	recql5	RecQ helicase-like 5. (1018 aa)
	LOC101471057	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1131 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1379 aa)
	ENSMZEP00005007474	Si:ch211-103n10.5. (229 aa)
	shld2	Si:ch211-134m17.9. (914 aa)
	ENSMZEP00005004425	H15 domain-containing protein. (180 aa)
	ENSMZEP00005004336	Zinc finger, RAN-binding domain containing 3. (997 aa)
	LOC112431780	H15 domain-containing protein. (152 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
	LOC101480102	Uncharacterized protein. (237 aa)
	fancb	FA complementation group B. (852 aa)
	ENSMZEP00005002226	H15 domain-containing protein. (160 aa)
	LOC112434930	H15 domain-containing protein. (210 aa)
	LOC112433468	Histone H1-like. (128 aa)
	ENSMZEP00005037181	H15 domain-containing protein. (146 aa)
	ENSMZEP00005035936	H15 domain-containing protein. (165 aa)
	LOC112430110	H15 domain-containing protein. (133 aa)
	LOC101482018	Mab-21 domain-containing protein. (481 aa)
	LOC112432145	H15 domain-containing protein. (157 aa)
	ENSMZEP00005034190	H15 domain-containing protein. (115 aa)
	LOC101469306	Si:ch1073-159d7.7. (203 aa)
	thoc1	THO complex 1. (654 aa)
	ENSMZEP00005032948	H15 domain-containing protein. (167 aa)
	ENSMZEP00005032364	H15 domain-containing protein. (123 aa)
	LOC112435366	H15 domain-containing protein. (154 aa)
	ENSMZEP00005031867	H15 domain-containing protein. (176 aa)
	ENSMZEP00005030990	H15 domain-containing protein. (157 aa)
	rmi2	RecQ mediated genome instability 2. (146 aa)
	blm	BLM RecQ like helicase. (1381 aa)
	ENSMZEP00005029792	H15 domain-containing protein. (149 aa)
	ENSMZEP00005028771	H15 domain-containing protein. (152 aa)
	ENSMZEP00005028134	H15 domain-containing protein. (128 aa)
	rif1	Replication timing regulatory factor 1. (2240 aa)
	LOC101478593	Zinc finger, RAN-binding domain containing 3. (567 aa)
	LOC112431319	H15 domain-containing protein. (157 aa)
	LOC112436196	Histone H1-like. (152 aa)
	ENSMZEP00005026713	H15 domain-containing protein. (117 aa)
	ENSMZEP00005026149	H15 domain-containing protein. (162 aa)
	ENSMZEP00005025481	H15 domain-containing protein. (188 aa)
	ENSMZEP00005024577	H15 domain-containing protein. (198 aa)
	ankle1	Uncharacterized protein. (1145 aa)
	ENSMZEP00005022346	H15 domain-containing protein. (129 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1709 aa)
	radx	RPA1 related single stranded DNA binding protein. (843 aa)
	fbh1	F-box DNA helicase 1. (1077 aa)
	ENSMZEP00005001066	H15 domain-containing protein. (125 aa)
	ENSMZEP00005001243	H15 domain-containing protein. (118 aa)
	LOC112432876	H15 domain-containing protein. (217 aa)
	parpbp	PARP1 binding protein. (587 aa)
	smchd1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1546 aa)
	ENSMZEP00005002099	H15 domain-containing protein. (200 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMZEP00005004336	LOC101471057	ENSMZEP00005004336	ENSMZEP00005009509	Zinc finger, RAN-binding domain containing 3.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.417
ENSMZEP00005004336	blm	ENSMZEP00005004336	ENSMZEP00005029946	Zinc finger, RAN-binding domain containing 3.	BLM RecQ like helicase.	0.450
ENSMZEP00005004336	fbh1	ENSMZEP00005004336	ENSMZEP00005020276	Zinc finger, RAN-binding domain containing 3.	F-box DNA helicase 1.	0.558
ENSMZEP00005004336	radx	ENSMZEP00005004336	ENSMZEP00005020293	Zinc finger, RAN-binding domain containing 3.	RPA1 related single stranded DNA binding protein.	0.408
ENSMZEP00005004336	recql5	ENSMZEP00005004336	ENSMZEP00005011620	Zinc finger, RAN-binding domain containing 3.	RecQ helicase-like 5.	0.547
LOC101471057	ENSMZEP00005004336	ENSMZEP00005009509	ENSMZEP00005004336	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Zinc finger, RAN-binding domain containing 3.	0.417
LOC101471057	LOC101478593	ENSMZEP00005009509	ENSMZEP00005027769	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Zinc finger, RAN-binding domain containing 3.	0.417
LOC101471057	blm	ENSMZEP00005009509	ENSMZEP00005029946	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	BLM RecQ like helicase.	0.814
LOC101471057	fancb	ENSMZEP00005009509	ENSMZEP00005003092	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	FA complementation group B.	0.424
LOC101471057	fbh1	ENSMZEP00005009509	ENSMZEP00005020276	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	F-box DNA helicase 1.	0.554
LOC101471057	mlh1	ENSMZEP00005009509	ENSMZEP00005014648	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.890
LOC101471057	msh2	ENSMZEP00005009509	ENSMZEP00005003163	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.433
LOC101471057	msh6	ENSMZEP00005009509	ENSMZEP00005008716	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.438
LOC101471057	parp3	ENSMZEP00005009509	ENSMZEP00005013975	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Poly [ADP-ribose] polymerase.	0.476
LOC101471057	recql5	ENSMZEP00005009509	ENSMZEP00005011620	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	RecQ helicase-like 5.	0.676
LOC101471057	rmi2	ENSMZEP00005009509	ENSMZEP00005030182	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	RecQ mediated genome instability 2.	0.643
LOC101471057	terf2ip	ENSMZEP00005009509	ENSMZEP00005018526	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Uncharacterized protein.	0.549
LOC101478593	LOC101471057	ENSMZEP00005027769	ENSMZEP00005009509	Zinc finger, RAN-binding domain containing 3.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.417
LOC101478593	blm	ENSMZEP00005027769	ENSMZEP00005029946	Zinc finger, RAN-binding domain containing 3.	BLM RecQ like helicase.	0.450
LOC101478593	fbh1	ENSMZEP00005027769	ENSMZEP00005020276	Zinc finger, RAN-binding domain containing 3.	F-box DNA helicase 1.	0.558