(88 nodes) Negative regulation of neurogenesis network (Maylandia zebra)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC101468050	Nuclear receptor subfamily 1, group D, member 4b. (587 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	ENSMZEP00005008706	J domain-containing protein. (73 aa)
	LOC101482827	Uncharacterized protein; Belongs to the semaphorin family. (864 aa)
	sema6b	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb; Belongs to the semaphorin family. (870 aa)
	LOC101485526	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family. (859 aa)
	ENSMZEP00005007307	Sema domain-containing protein. (323 aa)
	ENSMZEP00005007292	Sema domain-containing protein; Belongs to the semaphorin family. (621 aa)
	ENSMZEP00005007276	Uncharacterized protein; Belongs to the semaphorin family. (626 aa)
	epha4	Eph receptor A4, like. (989 aa)
	nr1d1	Nuclear receptor subfamily 1, group d, member 1. (602 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (844 aa)
	LOC101484133	Neurogenin 1. (194 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (765 aa)
	notch1	Notch receptor 1a. (2480 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1631 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (812 aa)
	LOC101471184	Uncharacterized protein. (1497 aa)
	sema3a	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (799 aa)
	sema3e	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (731 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (862 aa)
	brinp1	Bone morphogenetic protein/retinoic acid inducible neural-specific 1. (761 aa)
	LOC101486054	Sortilin-related receptor, L(DLR class) A repeats containing. (1756 aa)
	rnf10	Ring finger protein 10. (764 aa)
	sema5b	Sema domain-containing protein. (1103 aa)
	dynlt1	Dynein, light chain, Tctex-type 1. (112 aa)
	nkx6-2	NK6 homeobox 2. (283 aa)
	LOC101472768	Unc-51 like autophagy activating kinase 1. (946 aa)
	LOC101467477	Sema domain-containing protein. (1098 aa)
	LOC101487486	Sema domain-containing protein; Belongs to the semaphorin family. (823 aa)
	LOC101487731	Uncharacterized protein; Belongs to the semaphorin family. (671 aa)
	rb1	Retinoblastoma 1. (912 aa)
	LOC101468868	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (934 aa)
	LOC101464944	Neurofibromin 2a (merlin). (614 aa)
	rtn4r	Reticulon 4 receptor. (467 aa)
	LOC101473768	Notch receptor 1b. (2520 aa)
	med23	Mediator complex subunit 23. (1395 aa)
	LOC101469003	Disco-interacting protein 2 homolog Ba. (1337 aa)
	sema4c	Uncharacterized protein; Belongs to the semaphorin family. (868 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (715 aa)
	LOC101475744	Uncharacterized protein; Belongs to the semaphorin family. (892 aa)
	LOC101475565	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Belongs to the semaphorin family. (1125 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (383 aa)
	LOC101466313	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC101480681	Disco interacting protein 2 homolog C. (1376 aa)
	ulk2	Unc-51 like autophagy activating kinase 2. (1039 aa)
	LOC101476675	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (775 aa)
	LOC101479196	Semaphorin 4e; Belongs to the semaphorin family. (745 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
	LOC101487922	Neurofibromin 2b (merlin). (593 aa)
	nfatc4	Nuclear factor of activated T cells 4. (849 aa)
	nkx6-1	NK6 homeobox 1. (320 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (479 aa)
	LOC101470126	Sema domain-containing protein; Belongs to the semaphorin family. (754 aa)
	sema5a	Sema domain-containing protein. (1078 aa)
	dnajb11	DnaJ heat shock protein family (Hsp40) member B11. (360 aa)
	rufy3	RUN and FYVE domain containing 3. (658 aa)
	LOC112435937	Uncharacterized protein. (626 aa)
	LOC101474544	Uncharacterized protein. (1092 aa)
	nf1	Neurofibromin 1b. (2713 aa)
	LOC101463683	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (611 aa)
	LOC101477799	Uncharacterized protein; Belongs to the peptidase S1 family. (489 aa)
	ENSMZEP00005016237	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
	sema6d	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family. (1104 aa)
	LOC101480805	Spartin b. (609 aa)
	ifrd1	Interferon-related developmental regulator 1. (427 aa)
	LOC101477659	Si:ch211-129c21.1; Belongs to the semaphorin family. (808 aa)
	LOC101476805	Kinesin-associated protein 3b. (778 aa)
	LOC101465295	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1090 aa)
	sema3f	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (805 aa)
	LOC101484813	Si:ch211-113g11.6; Belongs to the semaphorin family. (640 aa)
	LOC101469419	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	id1	Inhibitor of DNA binding 1, HLH protein. (131 aa)
	LOC101466548	Disco-interacting protein 2 homolog A. (1610 aa)
	LOC101474600	Si:dkey-49n23.1; Belongs to the semaphorin family. (799 aa)
	ryk	Receptor like tyrosine kinase. (629 aa)
	sema6a	Semaphorin 6A; Belongs to the semaphorin family. (1021 aa)
	LOC101477407	Sema domain-containing protein; Belongs to the semaphorin family. (837 aa)
	LOC101471730	Unc-51 like autophagy activating kinase 1a. (888 aa)
	ifrd2	Interferon-related developmental regulator 2. (454 aa)
	sema3b	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (805 aa)
	sema3g	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (789 aa)
	pcm1	Pericentriolar material 1. (2144 aa)
	LOC101483262	Disco-interacting protein 2 homolog Bb. (1291 aa)
	LOC101469754	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	ENSMZEP00005009465	Sema domain-containing protein; Belongs to the semaphorin family. (672 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMZEP00005016237	LOC101469754	ENSMZEP00005016237	ENSMZEP00005010110	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.422
ENSMZEP00005016237	ryk	ENSMZEP00005016237	ENSMZEP00005012053	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.672
ENSMZEP00005016237	wnt3a	ENSMZEP00005016237	ENSMZEP00005033480	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.423
LOC101463683	LOC101477799	ENSMZEP00005016587	ENSMZEP00005016388	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.901
LOC101464944	LOC101487922	ENSMZEP00005019221	ENSMZEP00005033197	Neurofibromin 2a (merlin).	Neurofibromin 2b (merlin).	0.901
LOC101464944	nf1	ENSMZEP00005019221	ENSMZEP00005000968	Neurofibromin 2a (merlin).	Neurofibromin 1b.	0.561
LOC101465295	cdk5	ENSMZEP00005014254	ENSMZEP00005033499	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.464
LOC101466313	LOC101469754	ENSMZEP00005034634	ENSMZEP00005010110	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.414
LOC101466313	ryk	ENSMZEP00005034634	ENSMZEP00005012053	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.680
LOC101466313	wnt3a	ENSMZEP00005034634	ENSMZEP00005033480	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.414
LOC101466548	med23	ENSMZEP00005012558	ENSMZEP00005016663	Disco-interacting protein 2 homolog A.	Mediator complex subunit 23.	0.590
LOC101467477	cdk5	ENSMZEP00005023394	ENSMZEP00005033499	Sema domain-containing protein.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.464
LOC101469003	med23	ENSMZEP00005002193	ENSMZEP00005016663	Disco-interacting protein 2 homolog Ba.	Mediator complex subunit 23.	0.590
LOC101469419	LOC101469754	ENSMZEP00005013640	ENSMZEP00005010110	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.414
LOC101469419	ryk	ENSMZEP00005013640	ENSMZEP00005012053	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.672
LOC101469419	wnt3a	ENSMZEP00005013640	ENSMZEP00005033480	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.421
LOC101469754	ENSMZEP00005016237	ENSMZEP00005010110	ENSMZEP00005016237	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.422
LOC101469754	LOC101466313	ENSMZEP00005010110	ENSMZEP00005034634	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.414
LOC101469754	LOC101469419	ENSMZEP00005010110	ENSMZEP00005013640	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.414
LOC101469754	WNT7A	ENSMZEP00005010110	ENSMZEP00005008860	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.414