(54 nodes) T cell receptor signaling pathway network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101474799	Tyrosine-protein kinase. (537 aa)
	LOC101464027	Uncharacterized protein. (373 aa)
	LOC101464787	Uncharacterized protein. (253 aa)
	LOC105940508	Uncharacterized protein. (350 aa)
	ENSMZEP00005026735	Uncharacterized protein. (235 aa)
	ENSMZEP00005026725	Uncharacterized protein. (271 aa)
	LOC101466245	Uncharacterized protein. (330 aa)
	ENSMZEP00005026703	Uncharacterized protein. (368 aa)
	LOC101483179	Si:dkey-181m9.8. (594 aa)
	rnf31	Uncharacterized protein. (1108 aa)
	Vtcn1	V-set domain containing T cell activation inhibitor 1. (275 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1195 aa)
	ENSMZEP00005024746	HERV-H LTR-associating 2a, tandem duplicate 2. (336 aa)
	sppl3	Signal peptide peptidase 3. (383 aa)
	LOC101472711	ANK_REP_REGION domain-containing protein. (435 aa)
	LOC101473405	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1312 aa)
	LOC101467216	Ring finger and CCCH-type domains 2. (1141 aa)
	LOC101475547	Uncharacterized protein. (566 aa)
	eif2b2	Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (354 aa)
	LOC101483263	Uncharacterized protein. (682 aa)
	eif2b4	Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (548 aa)
	stoml2	Stomatin (EPB72)-like 2. (356 aa)
	fyn	Tyrosine-protein kinase. (537 aa)
	LOC101471460	Uncharacterized protein. (1087 aa)
	LOC101473126	MALT paracaspase 1. (828 aa)
	nfkbid	ANK_REP_REGION domain-containing protein. (503 aa)
	cd247	Uncharacterized protein. (148 aa)
	eif2b5	Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (708 aa)
	LOC101472714	Raftlin, lipid raft linker 1a. (702 aa)
	LOC101479549	MALT paracaspase 2. (823 aa)
	eif2b1	Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (302 aa)
	cd276	CD276 molecule. (299 aa)
	LOC101477172	Zinc finger CCCH-type containing 12A. (632 aa)
	themis2	Thymocyte selection associated family member 2. (702 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (576 aa)
	rbck1	RanBP-type and C3HC4-type zinc finger containing 1. (519 aa)
	ENSMZEP00005003158	Tumor necrosis factor receptor superfamily, member 21. (600 aa)
	ENSMZEP00005000099	Ig-like domain-containing protein. (305 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1249 aa)
	LOC101466898	Ig-like domain-containing protein. (262 aa)
	ENSMZEP00005000057	Ig-like domain-containing protein. (219 aa)
	ENSMZEP00005026768	Uncharacterized protein. (350 aa)
	ENSMZEP00005026803	Uncharacterized protein. (387 aa)
	LOC101464498	Uncharacterized protein. (393 aa)
	LOC101470592	IGv domain-containing protein. (234 aa)
	tmem269	Si:dkey-205h13.1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (243 aa)
	LOC101466152	MALT paracaspase 3. (548 aa)
	ENSMZEP00005031405	Zinc finger CCCH-type containing 12A. (296 aa)
	bcl10	BCL10 immune signaling adaptor. (248 aa)
	eif2b3	Eukaryotic translation initiation factor 2B, subunit 3 gamma. (453 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1125 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (424 aa)
	LOC101474749	C3H1-type domain-containing protein. (644 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1321 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMZEP00005031405	LOC101472711	ENSMZEP00005031405	ENSMZEP00005023975	Zinc finger CCCH-type containing 12A.	ANK_REP_REGION domain-containing protein.	0.406
LOC101464787	Vtcn1	ENSMZEP00005026742	ENSMZEP00005026081	Uncharacterized protein.	V-set domain containing T cell activation inhibitor 1.	0.900
LOC101466152	bcl10	ENSMZEP00005029958	ENSMZEP00005032924	MALT paracaspase 3.	BCL10 immune signaling adaptor.	0.964
LOC101467216	rc3h1	ENSMZEP00005022732	ENSMZEP00005034135	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.736
LOC101470592	cd276	ENSMZEP00005028691	ENSMZEP00005010175	IGv domain-containing protein.	CD276 molecule.	0.600
LOC101470592	ptprc	ENSMZEP00005028691	ENSMZEP00005025150	IGv domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.473
LOC101471460	LOC101483179	ENSMZEP00005020937	ENSMZEP00005026625	Uncharacterized protein.	Si:dkey-181m9.8.	0.900
LOC101471460	rbck1	ENSMZEP00005020937	ENSMZEP00005006901	Uncharacterized protein.	RanBP-type and C3HC4-type zinc finger containing 1.	0.991
LOC101471460	ripk2	ENSMZEP00005020937	ENSMZEP00005008783	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.928
LOC101471460	rnf31	ENSMZEP00005020937	ENSMZEP00005026226	Uncharacterized protein.	Uncharacterized protein.	0.902
LOC101472711	ENSMZEP00005031405	ENSMZEP00005023975	ENSMZEP00005031405	ANK_REP_REGION domain-containing protein.	Zinc finger CCCH-type containing 12A.	0.406
LOC101472711	LOC101474749	ENSMZEP00005023975	ENSMZEP00005035171	ANK_REP_REGION domain-containing protein.	C3H1-type domain-containing protein.	0.406
LOC101472711	LOC101477172	ENSMZEP00005023975	ENSMZEP00005009216	ANK_REP_REGION domain-containing protein.	Zinc finger CCCH-type containing 12A.	0.406
LOC101473126	LOC101479549	ENSMZEP00005018146	ENSMZEP00005012080	MALT paracaspase 1.	MALT paracaspase 2.	0.903
LOC101473126	bcl10	ENSMZEP00005018146	ENSMZEP00005032924	MALT paracaspase 1.	BCL10 immune signaling adaptor.	0.996
LOC101473405	LOC101474799	ENSMZEP00005023164	ENSMZEP00005002373	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.414
LOC101473405	cd247	ENSMZEP00005023164	ENSMZEP00005016067	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.560
LOC101473405	fyn	ENSMZEP00005023164	ENSMZEP00005020946	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.414
LOC101473405	plcg2	ENSMZEP00005023164	ENSMZEP00005000076	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.902
LOC101473405	ripk2	ENSMZEP00005023164	ENSMZEP00005008783	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Receptor-interacting serine-threonine kinase 2.	0.421