(45 nodes) Bone morphogenesis network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101468418	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	foxn3	Checkpoint suppressor 1. (486 aa)
	LOC101487154	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
	mef2d	Myocyte enhancer factor 2d. (489 aa)
	anxa6	Annexin. (660 aa)
	edar	Ectodysplasin A receptor. (473 aa)
	trip11	Thyroid hormone receptor interactor 11. (1982 aa)
	ENSMZEP00005016882	Fras1 related extracellular matrix 1a. (1313 aa)
	tsku	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (355 aa)
	LOC101483538	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family. (405 aa)
	pex7	Peroxisomal biogenesis factor 7. (330 aa)
	LOC101472041	Golgi glycoprotein 1b. (1139 aa)
	LOC101485134	Golgi glycoprotein 1a. (1164 aa)
	LOC112430746	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (486 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
	LOC101472197	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	ENSMZEP00005024536	Transmembrane protein 119b. (290 aa)
	LOC101471329	Uncharacterized protein. (184 aa)
	LOC101471303	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	kat2a	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (798 aa)
	nab2	NGFI-A binding protein 2 (EGR1 binding protein 2). (498 aa)
	LOC101478246	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family. (410 aa)
	LOC101486624	Fras1 related extracellular matrix 1b. (2029 aa)
	LOC112429912	Uncharacterized protein. (2028 aa)
	LOC101470365	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (809 aa)
	LOC101465777	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (596 aa)
	ENSMZEP00005033929	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (627 aa)
	LOC101483640	RAP1A, member of RAS oncogene family a. (185 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (538 aa)
	MEF2D	Myocyte enhancer factor 2D. (591 aa)
	ENSMZEP00005035649	Uncharacterized protein. (311 aa)
	msx1	Muscle segment homeobox 1a. (283 aa)
	ENSMZEP00005007856	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (477 aa)
	LOC101473889	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1067 aa)
	ext2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
	ift80	Intraflagellar transport 80 homolog (Chlamydomonas). (778 aa)
	dhrs3	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	atg9a	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (855 aa)
	LOC101481167	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	LOC101477349	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (792 aa)
	rab23	RAB23, member RAS oncogene family. (235 aa)
	LOC101466020	Uncharacterized protein. (185 aa)
	sp5	Sp5 transcription factor a. (371 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101466020	LOC101471329	ENSMZEP00005007237	ENSMZEP00005025938	Uncharacterized protein.	Uncharacterized protein.	0.900
LOC101466020	LOC101483640	ENSMZEP00005007237	ENSMZEP00005035353	Uncharacterized protein.	RAP1A, member of RAS oncogene family a.	0.900
LOC101468418	LOC101487154	ENSMZEP00005036325	ENSMZEP00005010869	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC101470365	atg9a	ENSMZEP00005033496	ENSMZEP00005001809	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.902
LOC101471303	dhrs3	ENSMZEP00005026446	ENSMZEP00005001339	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family.	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.525
LOC101471329	LOC101466020	ENSMZEP00005025938	ENSMZEP00005007237	Uncharacterized protein.	Uncharacterized protein.	0.900
LOC101471329	LOC101483640	ENSMZEP00005025938	ENSMZEP00005035353	Uncharacterized protein.	RAP1A, member of RAS oncogene family a.	0.900
LOC101472041	LOC101485134	ENSMZEP00005020160	ENSMZEP00005021265	Golgi glycoprotein 1b.	Golgi glycoprotein 1a.	0.900
LOC101472197	LOC101473889	ENSMZEP00005023033	ENSMZEP00005000564	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.442
LOC101472197	LOC101481167	ENSMZEP00005023033	ENSMZEP00005003647	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
LOC101473889	LOC101472197	ENSMZEP00005000564	ENSMZEP00005023033	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
LOC101473889	fgf4	ENSMZEP00005000564	ENSMZEP00005022988	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
LOC101477349	kat2a	ENSMZEP00005006827	ENSMZEP00005030515	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.496
LOC101481167	LOC101472197	ENSMZEP00005003647	ENSMZEP00005023033	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
LOC101481167	fgf4	ENSMZEP00005003647	ENSMZEP00005022988	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
LOC101483640	LOC101466020	ENSMZEP00005035353	ENSMZEP00005007237	RAP1A, member of RAS oncogene family a.	Uncharacterized protein.	0.900
LOC101483640	LOC101471329	ENSMZEP00005035353	ENSMZEP00005025938	RAP1A, member of RAS oncogene family a.	Uncharacterized protein.	0.900
LOC101485134	LOC101472041	ENSMZEP00005021265	ENSMZEP00005020160	Golgi glycoprotein 1a.	Golgi glycoprotein 1b.	0.900
LOC101487154	LOC101468418	ENSMZEP00005010869	ENSMZEP00005036325	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
atg9a	LOC101470365	ENSMZEP00005001809	ENSMZEP00005033496	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.902