(62 nodes) Bicellular tight junction assembly network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CLDN20	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (242 aa)
	LOC101477346	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	LOC101482102	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	LOC101463582	Par-3 family cell polarity regulator alpha, b. (1410 aa)
	LOC101466532	MARVEL domain containing 2b. (588 aa)
	arl2	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	ENSMZEP00005004159	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (130 aa)
	LOC101478982	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
	ENSMZEP00005000674	Uncharacterized protein. (239 aa)
	LOC101469646	MADS-box domain-containing protein. (506 aa)
	PAK2	Non-specific serine/threonine protein kinase. (513 aa)
	ENSMZEP00005033201	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
	ENSMZEP00005033202	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (184 aa)
	ENSMZEP00005033203	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (200 aa)
	LOC101474481	Uncharacterized protein. (189 aa)
	ENSMZEP00005033207	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (148 aa)
	ENSMZEP00005033227	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (110 aa)
	ENSMZEP00005033295	Claudin b. (178 aa)
	ENSMZEP00005033298	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (166 aa)
	ENSMZEP00005033315	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (214 aa)
	bves	Blood vessel epicardial substance. (361 aa)
	LOC101476040	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (780 aa)
	LOC101484102	Endothelial cell-selective adhesion molecule. (402 aa)
	ENSMZEP00005032598	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	LOC101476694	Uncharacterized protein. (140 aa)
	ENSMZEP00005032662	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (143 aa)
	ENSMZEP00005032735	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (203 aa)
	cldn1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (223 aa)
	pak2	Non-specific serine/threonine protein kinase. (529 aa)
	LOC101480506	Claudin 34. (199 aa)
	LOC101475580	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	LOC101465004	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	tbcd	Tubulin folding cofactor D. (1177 aa)
	afdn	Afadin, adherens junction formation factor a. (1579 aa)
	ramp2	Receptor (G protein-coupled) activity modifying protein 2. (239 aa)
	LOC101464975	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	LOC112435423	Endothelial cell adhesion molecule a. (437 aa)
	LOC101486797	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (556 aa)
	LOC101464771	Si:busm1-52i16.2. (327 aa)
	LOC101464480	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (227 aa)
	LOC101463618	Si:ch211-191a24.4. (287 aa)
	PARD3	Par-3 family cell polarity regulator. (1374 aa)
	LOC101472769	Claudin 23a. (237 aa)
	rab13	Uncharacterized protein. (200 aa)
	ENSMZEP00005020489	MADS-box domain-containing protein. (477 aa)
	LOC101476456	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	LOC101477882	Uncharacterized protein. (1268 aa)
	LOC101471118	Ig-like domain-containing protein. (769 aa)
	ENSMZEP00005016016	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
	ENSMZEP00005016011	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (303 aa)
	LOC101478021	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	ENSMZEP00005015814	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	pof1b	POF1B actin binding protein. (550 aa)
	ect2	Epithelial cell transforming 2. (939 aa)
	CLDN14	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (247 aa)
	SRF	Serum response factor. (618 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	LOC101482283	Occludin a. (503 aa)
	LOC101480447	MARVEL domain containing 2a. (571 aa)
	LOC101484717	Platelet/endothelial cell adhesion molecule 1. (793 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (876 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN14	CLDN20	ENSMZEP00005014317	ENSMZEP00005007356	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.671
CLDN14	ENSMZEP00005000674	ENSMZEP00005014317	ENSMZEP00005000674	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.655
CLDN14	ENSMZEP00005004159	ENSMZEP00005014317	ENSMZEP00005004159	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664
CLDN14	ENSMZEP00005016011	ENSMZEP00005014317	ENSMZEP00005016011	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.679
CLDN14	ENSMZEP00005016016	ENSMZEP00005014317	ENSMZEP00005016016	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.679
CLDN14	ENSMZEP00005032598	ENSMZEP00005014317	ENSMZEP00005032598	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.695
CLDN14	ENSMZEP00005032662	ENSMZEP00005014317	ENSMZEP00005032662	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN14	ENSMZEP00005032735	ENSMZEP00005014317	ENSMZEP00005032735	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN14	ENSMZEP00005033202	ENSMZEP00005014317	ENSMZEP00005033202	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN14	ENSMZEP00005033207	ENSMZEP00005014317	ENSMZEP00005033207	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN14	ENSMZEP00005033227	ENSMZEP00005014317	ENSMZEP00005033227	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN14	ENSMZEP00005033298	ENSMZEP00005014317	ENSMZEP00005033298	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.695
CLDN14	ENSMZEP00005033315	ENSMZEP00005014317	ENSMZEP00005033315	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.695
CLDN14	LOC101463582	ENSMZEP00005014317	ENSMZEP00005006329	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Par-3 family cell polarity regulator alpha, b.	0.672
CLDN14	LOC101464480	ENSMZEP00005014317	ENSMZEP00005024019	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664
CLDN14	LOC101464771	ENSMZEP00005014317	ENSMZEP00005024022	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Si:busm1-52i16.2.	0.664
CLDN14	LOC101464975	ENSMZEP00005014317	ENSMZEP00005033200	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN14	LOC101465004	ENSMZEP00005014317	ENSMZEP00005028822	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.696
CLDN14	LOC101474481	ENSMZEP00005014317	ENSMZEP00005033204	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.667
CLDN14	LOC101475580	ENSMZEP00005014317	ENSMZEP00005027907	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.650