STRINGSTRING
ercc4 ercc4 LOC101485261 LOC101485261 wdr13 wdr13 ENSMZEP00005033633 ENSMZEP00005033633 PRDM15 PRDM15 EZH1 EZH1 LOC101480650 LOC101480650 znf750 znf750 polr2a polr2a bmi1 bmi1 LOC101477072 LOC101477072 taf10 taf10 dnmt1 dnmt1 LOC101475117 LOC101475117 setdb1 setdb1 LOC101487216 LOC101487216 med1 med1 dhx9 dhx9 LOC101464777 LOC101464777 ezh2 ezh2 LOC101466323 LOC101466323 gtf2f1 gtf2f1 pcgf2 pcgf2 egr1 egr1 sirt1 sirt1 GADD45A GADD45A prdm1 prdm1 ercc1 ercc1 LOC101474771 LOC101474771 ENSMZEP00005010155 ENSMZEP00005010155 rbl1 rbl1 gtf2b gtf2b kdm1a kdm1a pcgf1 pcgf1 myf5 myf5 ENSMZEP00005037752 ENSMZEP00005037752 mecp2 mecp2 ENSMZEP00005035497 ENSMZEP00005035497
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ercc4Excision repair cross-complementation group 4. (899 aa)
LOC101485261PR domain containing 1b, with ZNF domain. (637 aa)
wdr13WD repeat domain 13. (482 aa)
ENSMZEP00005033633Peptidase S59 domain-containing protein. (759 aa)
PRDM15PR/SET domain 15. (1119 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (766 aa)
LOC101480650Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (359 aa)
znf750Zinc finger protein 750. (604 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1966 aa)
bmi1Bmi1 polycomb ring finger oncogene 1a. (335 aa)
LOC101477072Retinoblastoma-like 2 (p130). (1075 aa)
taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1502 aa)
LOC101475117Uncharacterized protein. (784 aa)
setdb1SET domain bifurcated histone lysine methyltransferase 1b. (1229 aa)
LOC101487216Myogenic factor. (299 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1752 aa)
dhx9DEAH (Asp-Glu-Ala-His) box helicase 9. (1271 aa)
LOC101464777SET domain-containing protein. (624 aa)
ezh2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (763 aa)
LOC101466323Interferon regulatory factor 3. (465 aa)
gtf2f1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (532 aa)
pcgf2Polycomb group ring finger 2. (331 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (514 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (715 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha, b. (183 aa)
prdm1PR domain containing 1a, with ZNF domain. (798 aa)
ercc1Excision repair cross-complementation group 1. (352 aa)
LOC101474771Nucleoporin 98. (1752 aa)
ENSMZEP00005010155Nup96 domain-containing protein. (398 aa)
rbl1Retinoblastoma-like 1 (p107). (1062 aa)
gtf2bGeneral transcription factor IIB. (318 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (834 aa)
pcgf1Polycomb group ring finger 1. (261 aa)
myf5Myogenic factor. (299 aa)
ENSMZEP00005037752Uncharacterized protein. (328 aa)
mecp2MBD domain-containing protein. (1059 aa)
ENSMZEP00005035497C2H2-type domain-containing protein. (330 aa)
Your Current Organism:
Maylandia zebra
NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.