(36 nodes) Regulation of CD4-positive, alpha-beta T cell activation network (Maylandia zebra)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101476142	NACHT domain-containing protein. (918 aa)
	LOC101474749	C3H1-type domain-containing protein. (644 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (538 aa)
	ENSMZEP00005000272	Uncharacterized protein. (748 aa)
	lgals9	Galectin. (318 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (379 aa)
	LOC101473695	Fibronectin type-III domain-containing protein. (354 aa)
	LOC101482216	E3 ubiquitin-protein ligase. (864 aa)
	socs1	Suppressor of cytokine signaling 1a. (216 aa)
	tbx21	T-box transcription factor 21. (621 aa)
	ENSMZEP00005011450	Uncharacterized protein. (632 aa)
	cd83	Ig-like domain-containing protein. (225 aa)
	LOC101479549	MALT paracaspase 2. (823 aa)
	vsir	V-set immunoregulatory receptor. (303 aa)
	nfkbid	ANK_REP_REGION domain-containing protein. (503 aa)
	LOC101473126	MALT paracaspase 1. (828 aa)
	myb	V-myb avian myeloblastosis viral oncogene homolog. (564 aa)
	cbfb	Core-binding factor subunit beta. (188 aa)
	LOC112430746	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (486 aa)
	LOC101467216	Ring finger and CCCH-type domains 2. (1141 aa)
	ENSMZEP00005023297	Uncharacterized protein. (732 aa)
	ENSMZEP00005023925	Uncharacterized protein. (288 aa)
	LOC101472711	ANK_REP_REGION domain-containing protein. (435 aa)
	ENSMZEP00005027247	Uncharacterized protein. (646 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (576 aa)
	LOC101477172	Zinc finger CCCH-type containing 12A. (632 aa)
	card11	Caspase recruitment domain family, member 11. (1162 aa)
	sash3	SAM and SH3 domain containing 3. (389 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1125 aa)
	ENSMZEP00005033929	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (627 aa)
	LOC101465777	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (596 aa)
	ENSMZEP00005031405	Zinc finger CCCH-type containing 12A. (296 aa)
	LOC101466152	MALT paracaspase 3. (548 aa)
	LOC101474118	E3 ubiquitin-protein ligase. (888 aa)
	LOC101470592	IGv domain-containing protein. (234 aa)
	sh3rf1	SH3 domain containing ring finger 1. (862 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMZEP00005011450	ripk2	ENSMZEP00005011450	ENSMZEP00005008783	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.547
ENSMZEP00005023925	lgals9	ENSMZEP00005023925	ENSMZEP00005000470	Uncharacterized protein.	Galectin.	0.580
ENSMZEP00005031405	LOC101472711	ENSMZEP00005031405	ENSMZEP00005023975	Zinc finger CCCH-type containing 12A.	ANK_REP_REGION domain-containing protein.	0.406
LOC101466152	card11	ENSMZEP00005029958	ENSMZEP00005009333	MALT paracaspase 3.	Caspase recruitment domain family, member 11.	0.893
LOC101467216	rc3h1	ENSMZEP00005022732	ENSMZEP00005034135	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.736
LOC101472711	ENSMZEP00005031405	ENSMZEP00005023975	ENSMZEP00005031405	ANK_REP_REGION domain-containing protein.	Zinc finger CCCH-type containing 12A.	0.406
LOC101472711	LOC101474749	ENSMZEP00005023975	ENSMZEP00005035171	ANK_REP_REGION domain-containing protein.	C3H1-type domain-containing protein.	0.406
LOC101472711	LOC101477172	ENSMZEP00005023975	ENSMZEP00005009216	ANK_REP_REGION domain-containing protein.	Zinc finger CCCH-type containing 12A.	0.406
LOC101473126	LOC101479549	ENSMZEP00005018146	ENSMZEP00005012080	MALT paracaspase 1.	MALT paracaspase 2.	0.903
LOC101473126	card11	ENSMZEP00005018146	ENSMZEP00005009333	MALT paracaspase 1.	Caspase recruitment domain family, member 11.	0.893
LOC101474118	LOC101482216	ENSMZEP00005029313	ENSMZEP00005006346	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.900
LOC101474118	ripk2	ENSMZEP00005029313	ENSMZEP00005008783	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.547
LOC101474749	LOC101472711	ENSMZEP00005035171	ENSMZEP00005023975	C3H1-type domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.406
LOC101477172	LOC101472711	ENSMZEP00005009216	ENSMZEP00005023975	Zinc finger CCCH-type containing 12A.	ANK_REP_REGION domain-containing protein.	0.406
LOC101479549	LOC101473126	ENSMZEP00005012080	ENSMZEP00005018146	MALT paracaspase 2.	MALT paracaspase 1.	0.903
LOC101479549	card11	ENSMZEP00005012080	ENSMZEP00005009333	MALT paracaspase 2.	Caspase recruitment domain family, member 11.	0.893
LOC101482216	LOC101474118	ENSMZEP00005006346	ENSMZEP00005029313	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.900
LOC101482216	ripk2	ENSMZEP00005006346	ENSMZEP00005008783	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.547
card11	LOC101466152	ENSMZEP00005009333	ENSMZEP00005029958	Caspase recruitment domain family, member 11.	MALT paracaspase 3.	0.893
card11	LOC101473126	ENSMZEP00005009333	ENSMZEP00005018146	Caspase recruitment domain family, member 11.	MALT paracaspase 1.	0.893