(122 nodes) EGF-type aspartate/asparagine hydroxylation site network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ldlr	Low density lipoprotein receptor a. (921 aa)
	slit1	Slit homolog 1a (Drosophila). (1535 aa)
	LOC101466133	Coagulation factor IXb. (530 aa)
	LOC101480300	Slit homolog 3 (Drosophila). (1512 aa)
	LOC101469369	Uncharacterized protein. (719 aa)
	egf	Epidermal growth factor. (953 aa)
	fat3	FAT atypical cadherin 3a. (4611 aa)
	LOC101484162	Uncharacterized protein. (611 aa)
	LOC101483022	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1215 aa)
	nid2	Nidogen 2a (osteonidogen). (1531 aa)
	LOC101471148	Uncharacterized protein. (1357 aa)
	LOC101472505	Sushi domain containing 1. (545 aa)
	notch1	Notch receptor 1a. (2480 aa)
	dlk2	Delta-like 2 homolog (Drosophila). (394 aa)
	LOC101473006	Fibrillin 2b. (2790 aa)
	lrp1b	Low density lipoprotein receptor-related protein 1Bb. (4563 aa)
	egfl6	EGF-like-domain, multiple 6. (539 aa)
	pros1	Protein S. (679 aa)
	gas6	Uncharacterized protein. (649 aa)
	megf8	Multiple EGF-like-domains 8. (2877 aa)
	FAT4	FAT atypical cadherin 4. (4975 aa)
	dner	Delta/notch-like EGF repeat containing. (759 aa)
	LOC101480797	Protein Z, vitamin K-dependent plasma glycoprotein a; Belongs to the peptidase S1 family. (418 aa)
	LOC101464439	Adhesion G protein-coupled receptor E5b, duplicate 3; Belongs to the G-protein coupled receptor 2 family. (741 aa)
	egfl7	EGF-like-domain, multiple 7. (294 aa)
	LOC101468567	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1213 aa)
	DLK1	Delta like non-canonical Notch ligand 1. (391 aa)
	LOC101467318	Si:ch211-186j3.6; Cadherins are calcium-dependent cell adhesion proteins. (2605 aa)
	LOC101470445	Zgc:158328. (1337 aa)
	LOC101476894	Uncharacterized protein. (589 aa)
	LOC101482222	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (717 aa)
	efemp2	EGF containing fibulin extracellular matrix protein 2a. (438 aa)
	ENSMZEP00005007203	Eyes shut homolog. (209 aa)
	LOC101465403	Uncharacterized protein. (389 aa)
	LOC101471475	Notch receptor 2. (2497 aa)
	lrp2	Low density lipoprotein receptor-related protein 2a. (4565 aa)
	LOC101487720	Coagulation factor IXa. (534 aa)
	LOC101485002	Fibulin 2. (1366 aa)
	fbln7	Fibulin 7. (443 aa)
	LOC101485175	Uncharacterized protein. (369 aa)
	LOC101472613	Low density lipoprotein receptor-related protein 1Aa. (4504 aa)
	fat1	FAT atypical cadherin 1a. (4627 aa)
	FBN1	Fibrillin 1. (2866 aa)
	tll1	Metalloendopeptidase. (1028 aa)
	scube1	Signal peptide, CUB domain, EGF-like 1. (949 aa)
	LOC101467170	Uncharacterized protein. (1020 aa)
	EFEMP1	EGF containing fibulin extracellular matrix protein 1. (266 aa)
	LOC101466914	Low density lipoprotein receptor-related protein 1Ab. (4417 aa)
	scube3	Signal peptide, CUB domain, EGF-like 3. (929 aa)
	FBLN2	Fibulin 2. (1195 aa)
	LOC101468057	Cysteine-rich with EGF-like domains 1b. (406 aa)
	adgrl4	Adhesion G protein-coupled receptor L4; Belongs to the G-protein coupled receptor 2 family. (768 aa)
	LOC101468755	Uncharacterized protein. (1296 aa)
	LOC101466506	Matrilin 3a. (486 aa)
	ltbp4	Uncharacterized protein. (1426 aa)
	LOC101472085	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (681 aa)
	LOC101464283	Low density lipoprotein receptor b. (833 aa)
	LOC106675973	Low density lipoprotein receptor b. (844 aa)
	slit2	Slit homolog 2 (Drosophila). (1528 aa)
	LOC101474783	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (627 aa)
	umodl1	Uncharacterized protein. (866 aa)
	ENSMZEP00005030576	EGF-like domain-containing protein. (430 aa)
	LOC101486834	C-type lectin domain-containing protein. (375 aa)
	LOC101464683	Nidogen 1b. (1306 aa)
	svep1	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3536 aa)
	proc	Uncharacterized protein. (442 aa)
	ccbe1	Collagen and calcium binding EGF domains 1. (399 aa)
	npnt	Nephronectin a. (623 aa)
	LOC101466883	FAT atypical cadherin 3b. (4320 aa)
	LOC101483715	Uncharacterized protein. (810 aa)
	crb1	Crumbs cell polarity complex component 1. (1317 aa)
	LOC101484507	Notch receptor 3. (2464 aa)
	ltbp1	Latent transforming growth factor beta binding protein 1. (1446 aa)
	hmcn1	Hemicentin 1. (5416 aa)
	LOC101478248	Metalloendopeptidase. (969 aa)
	crb2	Crumbs cell polarity complex component 2b. (1467 aa)
	ENSMZEP00005022507	Si:dkey-88l16.3. (1406 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1239 aa)
	cubn	Cubilin (intrinsic factor-cobalamin receptor). (3625 aa)
	LOC105941259	Sushi domain-containing protein. (438 aa)
	VWDE	Von Willebrand factor D and EGF domains. (886 aa)
	creld2	Cysteine-rich with EGF-like domains 2. (361 aa)
	scube2	Signal peptide, CUB domain, EGF-like 2. (1020 aa)
	LOC101488116	Low density lipoprotein receptor-related protein 2b. (4227 aa)
	vcan	Uncharacterized protein. (4044 aa)
	edil3	EGF-like repeats and discoidin I-like domains 3a. (436 aa)
	ENSMZEP00005019378	Slit homolog 1b (Drosophila). (948 aa)
	NELL1	Neural EGFL like 1. (730 aa)
	lrp4	Low density lipoprotein receptor-related protein 4. (1833 aa)
	vldlr	Very low density lipoprotein receptor. (844 aa)
	LOC101473768	Notch receptor 1b. (2520 aa)
	megf6	Multiple EGF-like-domains 6b. (1598 aa)
	ENSMZEP00005018416	Si:ch211-241f5.3; Belongs to the G-protein coupled receptor 2 family. (777 aa)
	dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
	LOC101468235	Uncharacterized protein. (450 aa)
	ENSMZEP00005016581	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (542 aa)
	ENSMZEP00005016578	EGF-like domain-containing protein. (203 aa)
	ENSMZEP00005016541	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (660 aa)
	LOC101474919	Bone morphogenetic protein 1a. (967 aa)
	LOC101482831	Milk fat globule-EGF factor 8 protein a. (476 aa)
	LOC101466573	Coagulation factor X. (503 aa)
	LOC101480954	Versican b. (1432 aa)
	LOC101464266	Milk fat globule-EGF factor 8 protein b. (476 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (714 aa)
	celsr2	Cadherin, EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (3015 aa)
	ENSMZEP00005014697	Uncharacterized protein. (385 aa)
	fbln5	Fibulin 5. (463 aa)
	heg1	Heart development protein with EGF-like domains 1. (1072 aa)
	fbln1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (685 aa)
	nid1	Nidogen 1a. (1196 aa)
	CRB2	Uncharacterized protein. (1447 aa)
	LOC101479437	CD248 molecule, endosialin a. (679 aa)
	LOC101480547	Uncharacterized protein. (965 aa)
	LOC101468020	Matrilin 3b. (704 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1222 aa)
	ENSMZEP00005012302	Si:ch211-194g2.4. (143 aa)
	LOC101481403	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
	hmcn2	Hemicentin 2. (4187 aa)
	sned1	Sushi, nidogen and EGF-like domains 1. (1287 aa)
	LOC101478535	Uncharacterized protein. (1478 aa)
	LOC101480092	Si:dkey-22o22.2; Cadherins are calcium-dependent cell adhesion proteins. (2807 aa)
	nell2	Neural EGFL like 2a. (803 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLK1	LOC101473768	ENSMZEP00005006267	ENSMZEP00005018744	Delta like non-canonical Notch ligand 1.	Notch receptor 1b.	0.593
DLK1	egf	ENSMZEP00005006267	ENSMZEP00005001650	Delta like non-canonical Notch ligand 1.	Epidermal growth factor.	0.485
DLK1	notch1	ENSMZEP00005006267	ENSMZEP00005002920	Delta like non-canonical Notch ligand 1.	Notch receptor 1a.	0.593
ENSMZEP00005007203	egf	ENSMZEP00005007203	ENSMZEP00005001650	Eyes shut homolog.	Epidermal growth factor.	0.452
ENSMZEP00005014697	fat1	ENSMZEP00005014697	ENSMZEP00005009799	Uncharacterized protein.	FAT atypical cadherin 1a.	0.425
ENSMZEP00005022507	egf	ENSMZEP00005022507	ENSMZEP00005001650	Si:dkey-88l16.3.	Epidermal growth factor.	0.451
ENSMZEP00005030576	proc	ENSMZEP00005030576	ENSMZEP00005027137	EGF-like domain-containing protein.	Uncharacterized protein.	0.683
FAT4	fat1	ENSMZEP00005004207	ENSMZEP00005009799	FAT atypical cadherin 4.	FAT atypical cadherin 1a.	0.425
LOC101464283	ldlr	ENSMZEP00005032011	ENSMZEP00005005148	Low density lipoprotein receptor b.	Low density lipoprotein receptor a.	0.901
LOC101466133	proc	ENSMZEP00005000949	ENSMZEP00005027137	Coagulation factor IXb.	Uncharacterized protein.	0.553
LOC101466573	proc	ENSMZEP00005016199	ENSMZEP00005027137	Coagulation factor X.	Uncharacterized protein.	0.538
LOC101466883	fat3	ENSMZEP00005026172	ENSMZEP00005001659	FAT atypical cadherin 3b.	FAT atypical cadherin 3a.	0.506
LOC101468567	LOC101471475	ENSMZEP00005005843	ENSMZEP00005007988	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.957
LOC101468567	LOC101473768	ENSMZEP00005005843	ENSMZEP00005018744	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1b.	0.981
LOC101468567	LOC101484507	ENSMZEP00005005843	ENSMZEP00005025035	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.957
LOC101468567	notch1	ENSMZEP00005005843	ENSMZEP00005002920	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1a.	0.981
LOC101468755	LOC101480954	ENSMZEP00005034193	ENSMZEP00005015726	Uncharacterized protein.	Versican b.	0.561
LOC101468755	vcan	ENSMZEP00005034193	ENSMZEP00005019454	Uncharacterized protein.	Uncharacterized protein.	0.532
LOC101471148	egf	ENSMZEP00005002430	ENSMZEP00005001650	Uncharacterized protein.	Epidermal growth factor.	0.451
LOC101471475	LOC101468567	ENSMZEP00005007988	ENSMZEP00005005843	Notch receptor 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.957