(62 nodes) ATPase, AAA-type, core network (Maylandia zebra)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101477540	N-ethylmaleimide-sensitive factor a. (751 aa)
	afg3l2	AFG3-like AAA ATPase 2. (800 aa)
	LOC101481666	Uncharacterized protein; Belongs to the AAA ATPase family. (435 aa)
	katnal2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (380 aa)
	LOC101486464	Si:ch1073-174d20.2. (762 aa)
	katna1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (488 aa)
	LOC101470270	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (436 aa)
	psmc5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (407 aa)
	psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (423 aa)
	LOC101465291	BC1 (ubiquinol-cytochrome c reductase) synthesis-like; Belongs to the AAA ATPase family. (420 aa)
	rfc1	Replication factor C subunit 1. (1161 aa)
	nav3	Neuron navigator 3. (2379 aa)
	LOC101471502	AAA domain-containing protein; Belongs to the AAA ATPase family. (687 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (748 aa)
	fignl1	Fidgetin-like 1; Belongs to the AAA ATPase family. (637 aa)
	chtf18	AAA domain-containing protein. (922 aa)
	ATAD3A	ATPase family AAA domain containing 3A. (665 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	atad5	ATPase family AAA domain containing 5a. (1807 aa)
	psmc3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (476 aa)
	LOC101478072	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (840 aa)
	atad2b	ATPase family AAA domain containing 2B. (1452 aa)
	spast	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (519 aa)
	LOC101469523	YME1-like 1b. (719 aa)
	LOC101473243	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (381 aa)
	LOC101485137	AAA domain-containing protein. (853 aa)
	LOC101472618	AAA domain-containing protein; Belongs to the AAA ATPase family. (424 aa)
	ENSMZEP00005032568	Uncharacterized protein; Belongs to the AAA ATPase family. (482 aa)
	wrnip1	WRN helicase interacting protein 1. (603 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (437 aa)
	rfc2	Replication factor C (activator 1) 2. (356 aa)
	LOC101472130	Bromo domain-containing protein. (1150 aa)
	LOC101466991	AAA domain-containing protein; Belongs to the AAA ATPase family. (345 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (382 aa)
	LOC101470525	N-ethylmaleimide-sensitive factor b. (746 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (673 aa)
	atad2	ATPase family AAA domain containing 2. (1317 aa)
	ENSMZEP00005009292	Fidgetin; Belongs to the AAA ATPase family. (644 aa)
	psmc1	Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
	pex1	Peroxisomal biogenesis factor 1. (1247 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (602 aa)
	LOC101483411	Zgc:136908; Belongs to the AAA ATPase family. (806 aa)
	ENSMZEP00005005492	AAA domain-containing protein; Belongs to the AAA ATPase family. (377 aa)
	SPATA5	Spermatogenesis associated 5. (898 aa)
	LOC101475817	Zgc:153738. (739 aa)
	clpx	Caseinolytic mitochondrial matrix peptidase chaperone subunit b. (610 aa)
	spg7	SPG7 matrix AAA peptidase subunit, paraplegin. (808 aa)
	pex6	Peroxisomal biogenesis factor 6. (1049 aa)
	FIGNL2	Fidgetin like 2. (677 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	LOC101464095	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (484 aa)
	ENSMZEP00005021886	Katanin p60 subunit A-like 2. (275 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	psmc4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
	orc1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (899 aa)
	lonp1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1002 aa)
	LOC101481907	AAA domain-containing protein. (756 aa)
	atad1	ATPase family AAA domain containing 1b; Belongs to the AAA ATPase family. (364 aa)
	nvl	Nuclear VCP like. (842 aa)
	LOC101479261	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family. (381 aa)
	LOC101474488	YME1-like 1a. (731 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLPB	ENSMZEP00005021886	ENSMZEP00005009954	ENSMZEP00005021886	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Katanin p60 subunit A-like 2.	0.601
CLPB	LOC101465291	ENSMZEP00005009954	ENSMZEP00005019379	ClpB homolog, mitochondrial AAA ATPase chaperonin.	BC1 (ubiquinol-cytochrome c reductase) synthesis-like; Belongs to the AAA ATPase family.	0.458
CLPB	LOC101469523	ENSMZEP00005009954	ENSMZEP00005010905	ClpB homolog, mitochondrial AAA ATPase chaperonin.	YME1-like 1b.	0.496
CLPB	LOC101471502	ENSMZEP00005009954	ENSMZEP00005016683	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.458
CLPB	LOC101474488	ENSMZEP00005009954	ENSMZEP00005025186	ClpB homolog, mitochondrial AAA ATPase chaperonin.	YME1-like 1a.	0.496
CLPB	LOC101478072	ENSMZEP00005009954	ENSMZEP00005014521	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-.	0.813
CLPB	LOC101486464	ENSMZEP00005009954	ENSMZEP00005021326	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Si:ch1073-174d20.2.	0.458
CLPB	afg3l2	ENSMZEP00005009954	ENSMZEP00005026029	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AFG3-like AAA ATPase 2.	0.458
CLPB	clpx	ENSMZEP00005009954	ENSMZEP00005003076	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Caseinolytic mitochondrial matrix peptidase chaperone subunit b.	0.768
CLPB	katnal2	ENSMZEP00005009954	ENSMZEP00005021866	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.601
CLPB	lonp1	ENSMZEP00005009954	ENSMZEP00005024058	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.813
CLPB	spg7	ENSMZEP00005009954	ENSMZEP00005002665	ClpB homolog, mitochondrial AAA ATPase chaperonin.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.458
ENSMZEP00005005492	LOC101470270	ENSMZEP00005005492	ENSMZEP00005020100	AAA domain-containing protein; Belongs to the AAA ATPase family.	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family.	0.430
ENSMZEP00005005492	LOC101481666	ENSMZEP00005005492	ENSMZEP00005026756	AAA domain-containing protein; Belongs to the AAA ATPase family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.430
ENSMZEP00005005492	VPS4B	ENSMZEP00005005492	ENSMZEP00005033973	AAA domain-containing protein; Belongs to the AAA ATPase family.	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.	0.430
ENSMZEP00005005492	rfc4	ENSMZEP00005005492	ENSMZEP00005014921	AAA domain-containing protein; Belongs to the AAA ATPase family.	Replication factor C (activator 1) 4.	0.407
ENSMZEP00005021886	CLPB	ENSMZEP00005021886	ENSMZEP00005009954	Katanin p60 subunit A-like 2.	ClpB homolog, mitochondrial AAA ATPase chaperonin.	0.601
ENSMZEP00005021886	LOC101466991	ENSMZEP00005021886	ENSMZEP00005038034	Katanin p60 subunit A-like 2.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.405
ENSMZEP00005021886	LOC101479261	ENSMZEP00005021886	ENSMZEP00005025102	Katanin p60 subunit A-like 2.	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family.	0.400
ENSMZEP00005021886	cdc6	ENSMZEP00005021886	ENSMZEP00005007079	Katanin p60 subunit A-like 2.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.514