58 items (Maylandia zebra) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	npl	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase); Belongs to the DapA family. (333 aa)
	LOC101477816	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae). (699 aa)
	dus2	Dihydrouridine synthase 2. (498 aa)
	lias	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (371 aa)
	ENSMZEP00005031299	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (462 aa)
	dus1l	Dihydrouridine synthase 1-like (S. cerevisiae). (489 aa)
	mocs1	Molybdenum cofactor synthesis 1. (404 aa)
	gla	Alpha-galactosidase. (430 aa)
	LOC101471008	Hyaluronidase. (441 aa)
	LOC101475068	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (363 aa)
	dus3l	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (620 aa)
	hmgcl	3-hydroxy-3-methylglutaryl-CoA lyase. (337 aa)
	rsad2	Radical S-adenosyl methionine domain containing 2. (352 aa)
	LOC101464300	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (611 aa)
	hmgcll1	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. (338 aa)
	gmpr	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
	pc	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1180 aa)
	SPAM1-2	Hyaluronidase. (442 aa)
	LOC101466068	Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (442 aa)
	ENSMZEP00005028538	Hyaluronidase. (496 aa)
	LOC101481190	N-acetylneuraminic acid synthase a. (385 aa)
	LOC106674567	N-acetylneuraminic acid synthase b. (337 aa)
	LOC101467395	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
	dhodh	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (412 aa)
	umps	Uridine monophosphate synthetase. (485 aa)
	LOC101464675	Triosephosphate isomerase. (248 aa)
	LOC101463822	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (363 aa)
	LOC101482120	Triosephosphate isomerase. (247 aa)
	LOC101481823	Triosephosphate isomerase. (247 aa)
	naprt	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (556 aa)
	galc	Galactosylceramidase b. (665 aa)
	LOC105940732	Alpha-galactosidase. (397 aa)
	LOC101471811	Alpha-galactosidase. (397 aa)
	alad	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (331 aa)
	LOC101482688	Hyaluronidase. (462 aa)
	HYAL2-2	Hyaluronidase. (470 aa)
	dus4l	tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (299 aa)
	hoga1	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (328 aa)
	taldo1	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (338 aa)
	impdh2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (538 aa)
	LOC101480382	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
	LOC101471679	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (592 aa)
	hao2	Hydroxyacid oxidase 2 (long chain). (379 aa)
	dera	Deoxyribose-phosphate aldolase (putative). (318 aa)
	ENSMZEP00005037469	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (228 aa)
	hao1	Hydroxyacid oxidase (glycolate oxidase) 1. (372 aa)
	LOC101478695	Hyaluronidase. (475 aa)
	LOC101478980	Hyaluronidase. (515 aa)
	LOC101465268	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (339 aa)
	LOC112430017	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (363 aa)
	LOC101487903	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	HYAL2	Hyaluronidase. (477 aa)
	LOC112433108	Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (431 aa)
	QPRT	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (336 aa)
	nampt	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
	dpyd	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1021 aa)
	SPAM1	Hyaluronidase. (744 aa)
	SPAM1-3	Hyaluronidase. (468 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMZEP00005031299	QPRT	ENSMZEP00005031299	ENSMZEP00005016175	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.458
ENSMZEP00005031299	dhodh	ENSMZEP00005031299	ENSMZEP00005002486	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.924
ENSMZEP00005031299	dpyd	ENSMZEP00005031299	ENSMZEP00005014216	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.894
ENSMZEP00005037469	QPRT	ENSMZEP00005037469	ENSMZEP00005016175	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.458
ENSMZEP00005037469	dhodh	ENSMZEP00005037469	ENSMZEP00005002486	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.992
ENSMZEP00005037469	dpyd	ENSMZEP00005037469	ENSMZEP00005014216	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.988
ENSMZEP00005037469	umps	ENSMZEP00005037469	ENSMZEP00005002415	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	Uridine monophosphate synthetase.	0.901
LOC101463822	LOC101464675	ENSMZEP00005025588	ENSMZEP00005001967	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Triosephosphate isomerase.	0.967
LOC101463822	LOC101467395	ENSMZEP00005025588	ENSMZEP00005002734	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family.	0.408
LOC101463822	LOC101475068	ENSMZEP00005025588	ENSMZEP00005010529	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.802
LOC101463822	LOC101481823	ENSMZEP00005025588	ENSMZEP00005023804	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Triosephosphate isomerase.	0.967
LOC101463822	LOC101482120	ENSMZEP00005025588	ENSMZEP00005023811	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Triosephosphate isomerase.	0.967
LOC101463822	LOC101487903	ENSMZEP00005025588	ENSMZEP00005017675	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.818
LOC101463822	LOC112430017	ENSMZEP00005025588	ENSMZEP00005017925	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.802
LOC101463822	dera	ENSMZEP00005025588	ENSMZEP00005025658	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Deoxyribose-phosphate aldolase (putative).	0.908
LOC101463822	taldo1	ENSMZEP00005025588	ENSMZEP00005018368	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.951
LOC101464300	LOC101471679	ENSMZEP00005007280	ENSMZEP00005026339	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.900
LOC101464300	LOC101480382	ENSMZEP00005007280	ENSMZEP00005028239	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.918
LOC101464300	dhodh	ENSMZEP00005007280	ENSMZEP00005002486	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.549
LOC101464300	dpyd	ENSMZEP00005007280	ENSMZEP00005014216	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.459