STRINGSTRING
rfc4 rfc4 nhp2 nhp2 rfc2 rfc2 ENSMZEP00005035748 ENSMZEP00005035748 ankrd52 ankrd52 prim1 prim1 ENSMZEP00005034571 ENSMZEP00005034571 dscc1 dscc1 RPA1 RPA1 rfc3 rfc3 ccna1 ccna1 fen1 fen1 trub1 trub1 lig1 lig1 LOC101467722 LOC101467722 pold3 pold3 rfc1 rfc1 ENSMZEP00005031506 ENSMZEP00005031506 ruvbl2 ruvbl2 LOC101484379 LOC101484379 chtf8 chtf8 pot1 pot1 cdk2 cdk2 blm blm RCBTB1 RCBTB1 rfc5 rfc5 terf1 terf1 pola1 pola1 ankrd44 ankrd44 nop10 nop10 LOC101487465 LOC101487465 rpa3 rpa3 PPP6C PPP6C LOC101478306 LOC101478306 dkc1 dkc1 terf2ip terf2ip ankrd28 ankrd28 pold4 pold4 stn1 stn1 LOC101484173 LOC101484173 ENSMZEP00005016249 ENSMZEP00005016249 chtf18 chtf18 dna2 dna2 tert tert exd2 exd2 LOC101475652 LOC101475652 pold1 pold1 pold2 pold2 LOC101487114 LOC101487114 terf2 terf2 ENSMZEP00005012612 ENSMZEP00005012612 pcna pcna shq1 shq1 meiob meiob LOC101482023 LOC101482023 LOC101466422 LOC101466422 rpa1 rpa1 LOC101471057 LOC101471057 rpa2 rpa2 ENSMZEP00005007381 ENSMZEP00005007381 prim2 prim2 LOC101485698 LOC101485698 wrap53 wrap53 pif1 pif1 LOC106675102 LOC106675102 ENSMZEP00005005357 ENSMZEP00005005357 pola2 pola2 LOC101477005 LOC101477005 gar1 gar1 ten1 ten1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc4Replication factor C (activator 1) 4. (357 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (154 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
ENSMZEP00005035748RecQ helicase-like 4. (770 aa)
ankrd52Ankyrin repeat domain 52a. (1077 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
ENSMZEP00005034571Uncharacterized protein. (934 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (398 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
trub1TruB pseudouridine (psi) synthase family member 1. (278 aa)
lig1DNA ligase. (1013 aa)
LOC101467722Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa)
rfc1Replication factor C subunit 1. (1161 aa)
ENSMZEP00005031506Protein kinase domain-containing protein. (424 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (459 aa)
LOC101484379ANK_REP_REGION domain-containing protein. (1046 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa)
pot1Protection of telomeres 1 homolog. (669 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
blmBLM RecQ like helicase. (1381 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (366 aa)
pola1DNA polymerase. (1482 aa)
ankrd44Ankyrin repeat domain 44. (898 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
LOC101487465TERF1 (TRF1)-interacting nuclear factor 2. (580 aa)
rpa3Replication protein A3. (122 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
LOC101478306Uncharacterized protein. (496 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (500 aa)
terf2ipUncharacterized protein. (617 aa)
ankrd28Ankyrin repeat domain 28b. (1052 aa)
pold4Si:dkey-28b4.7. (107 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
LOC101484173Ankyrin repeat domain 66. (172 aa)
ENSMZEP00005016249ATP-dependent DNA helicase; Belongs to the helicase family. (709 aa)
chtf18AAA domain-containing protein. (922 aa)
dna2DNA replication helicase/nuclease 2. (1401 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1095 aa)
exd2Exonuclease 3'-5' domain containing 2. (640 aa)
LOC101475652Serine/threonine-protein phosphatase. (283 aa)
pold1DNA polymerase. (1105 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
LOC101487114HTH myb-type domain-containing protein. (706 aa)
terf2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (509 aa)
ENSMZEP00005012612ATP-dependent DNA helicase; Belongs to the helicase family. (744 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
shq1SHQ1, H/ACA ribonucleoprotein assembly factor. (630 aa)
meiobMethionine sulfoxide reductase B1b. (459 aa)
LOC101482023Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (530 aa)
LOC101466422Ankyrin repeat domain 28. (1101 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
LOC101471057Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1131 aa)
rpa2Replication protein A2. (293 aa)
ENSMZEP00005007381ATP-dependent DNA helicase; Belongs to the helicase family. (1531 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
LOC101485698Zgc:110269. (348 aa)
wrap53WD repeat containing, antisense to TP53. (544 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (632 aa)
LOC106675102Uncharacterized protein. (1000 aa)
ENSMZEP00005005357Uncharacterized protein. (1056 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
LOC101477005Cyclin A2; Belongs to the cyclin family. (434 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (223 aa)
ten1TEN1 subunit of CST complex. (130 aa)
Your Current Organism:
Maylandia zebra
NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna
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