57 items (Maylandia zebra) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSMZEP00005005366	Hydroxysteroid (11-beta) dehydrogenase 1-like a. (201 aa)
	ENSMZEP00005005150	MENTAL domain-containing protein. (244 aa)
	hsd17b14	Hydroxysteroid (17-beta) dehydrogenase 14. (264 aa)
	LOC106675461	Uncharacterized protein; Belongs to the cytochrome P450 family. (498 aa)
	STARD3NL	STARD3 N-terminal like. (234 aa)
	ENSMZEP00005038016	Cys_knot domain-containing protein. (141 aa)
	LOC101477086	Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (516 aa)
	LOC101475441	Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (521 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (468 aa)
	LOC101485638	Cys_knot domain-containing protein. (160 aa)
	POMC	Proopiomelanocortin. (233 aa)
	LOC101471311	Hydroxysteroid (11-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (406 aa)
	SERPINA4	Serpin family A member 4; Belongs to the serpin family. (456 aa)
	hsdl1	Hydroxysteroid dehydrogenase like 1. (325 aa)
	FDX1	Ferredoxin 1. (162 aa)
	fdxr	NADPH:adrenodoxin oxidoreductase, mitochondrial. (494 aa)
	hsd17b3	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa)
	LOC101468629	Cytochrome P450, family 19, subfamily A, polypeptide 1a; Belongs to the cytochrome P450 family. (506 aa)
	LOC101486610	Hydroxysteroid (11-beta) dehydrogenase 1-like a. (286 aa)
	LOC101486317	Hydroxysteroid (11-beta) dehydrogenase 1-like a. (287 aa)
	rimbp2	RIMS binding protein 2. (1416 aa)
	LOC101483108	Si:ch211-105f12.2. (220 aa)
	LOC101484346	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (251 aa)
	FADS6	Fatty acid desaturase 6. (372 aa)
	LOC101468689	Zgc:109982; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (322 aa)
	srd5a1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (265 aa)
	ENSMZEP00005000861	Cys_knot domain-containing protein. (105 aa)
	LOC101484273	START domain-containing protein. (278 aa)
	ENSMZEP00005033273	Cys_knot domain-containing protein. (165 aa)
	fdx2	Ferredoxin 2. (196 aa)
	tspoap1	Uncharacterized protein. (2140 aa)
	LOC101479908	Uncharacterized protein. (324 aa)
	stard3	StAR-related lipid transfer (START) domain containing 3. (454 aa)
	hsd17b1	Hydroxysteroid (17-beta) dehydrogenase 1. (318 aa)
	LOC101471001	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (517 aa)
	srd5a3	Steroid 5 alpha-reductase 3. (314 aa)
	LOC101485719	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (374 aa)
	LOC101484786	Retinol dehydrogenase 8a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	LOC101484243	Zmp:0000001048; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (308 aa)
	LOC101477975	Uncharacterized protein. (1002 aa)
	LOC101475601	Uncharacterized protein. (268 aa)
	sdr16c5	Short chain dehydrogenase/reductase family 16C, member 5a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (306 aa)
	LOC101464359	Hydroxysteroid (20-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa)
	LOC101463871	Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (542 aa)
	LOC101476244	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (247 aa)
	LOC101469758	Hydroxysteroid (17-beta) dehydrogenase 12b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	LOC101466310	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	tspo	Translocator protein. (161 aa)
	LOC101472385	Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (523 aa)
	pomc	Uncharacterized protein. (208 aa)
	hsd17b12	Hydroxysteroid (17-beta) dehydrogenase 12a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (327 aa)
	LOC101477205	Aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2. (316 aa)
	LOC101477496	Aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1. (316 aa)
	LOC101469342	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Belongs to the serpin family. (404 aa)
	ENSMZEP00005006076	Uncharacterized protein; Belongs to the cytochrome P450 family. (481 aa)
	dhrs7c	Dehydrogenase/reductase (SDR family) member 7Cb. (313 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP19A1	FDX1	ENSMZEP00005037130	ENSMZEP00005007924	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Ferredoxin 1.	0.446
CYP19A1	LOC101484273	ENSMZEP00005037130	ENSMZEP00005001003	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	START domain-containing protein.	0.446
CYP19A1	LOC101485719	ENSMZEP00005037130	ENSMZEP00005025844	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.	0.478
CYP19A1	fdx2	ENSMZEP00005037130	ENSMZEP00005032020	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Ferredoxin 2.	0.446
CYP19A1	hsd17b1	ENSMZEP00005037130	ENSMZEP00005030417	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid (17-beta) dehydrogenase 1.	0.456
CYP19A1	hsd17b3	ENSMZEP00005037130	ENSMZEP00005008606	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.480
ENSMZEP00005000861	LOC101485638	ENSMZEP00005000861	ENSMZEP00005036579	Cys_knot domain-containing protein.	Cys_knot domain-containing protein.	0.901
ENSMZEP00005000861	POMC	ENSMZEP00005000861	ENSMZEP00005036306	Cys_knot domain-containing protein.	Proopiomelanocortin.	0.413
ENSMZEP00005000861	pomc	ENSMZEP00005000861	ENSMZEP00005017281	Cys_knot domain-containing protein.	Uncharacterized protein.	0.413
ENSMZEP00005005150	FADS6	ENSMZEP00005005150	ENSMZEP00005012418	MENTAL domain-containing protein.	Fatty acid desaturase 6.	0.410
ENSMZEP00005005150	FDX1	ENSMZEP00005005150	ENSMZEP00005007924	MENTAL domain-containing protein.	Ferredoxin 1.	0.435
ENSMZEP00005005150	LOC101484273	ENSMZEP00005005150	ENSMZEP00005001003	MENTAL domain-containing protein.	START domain-containing protein.	0.738
ENSMZEP00005005150	fdx2	ENSMZEP00005005150	ENSMZEP00005032020	MENTAL domain-containing protein.	Ferredoxin 2.	0.435
ENSMZEP00005005150	fdxr	ENSMZEP00005005150	ENSMZEP00005008069	MENTAL domain-containing protein.	NADPH:adrenodoxin oxidoreductase, mitochondrial.	0.410
ENSMZEP00005005150	star	ENSMZEP00005005150	ENSMZEP00005013657	MENTAL domain-containing protein.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.627
ENSMZEP00005005150	stard3	ENSMZEP00005005150	ENSMZEP00005030634	MENTAL domain-containing protein.	StAR-related lipid transfer (START) domain containing 3.	0.705
ENSMZEP00005005366	FDX1	ENSMZEP00005005366	ENSMZEP00005007924	Hydroxysteroid (11-beta) dehydrogenase 1-like a.	Ferredoxin 1.	0.485
ENSMZEP00005005366	fdx2	ENSMZEP00005005366	ENSMZEP00005032020	Hydroxysteroid (11-beta) dehydrogenase 1-like a.	Ferredoxin 2.	0.485
ENSMZEP00005006076	FDX1	ENSMZEP00005006076	ENSMZEP00005007924	Uncharacterized protein; Belongs to the cytochrome P450 family.	Ferredoxin 1.	0.490
ENSMZEP00005006076	LOC101463871	ENSMZEP00005006076	ENSMZEP00005021485	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	0.458