Your Input: | |
| | LOC101477005 | Cyclin A2; Belongs to the cyclin family. (434 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (430 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1312 aa) |
| | ENSMZEP00005003692 | annotation not available (98 aa) |
| | ENSMZEP00005003901 | Histone H2B; Belongs to the histone H2B family. (113 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2554 aa) |
| | LOC112434931 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa) |
| | ENSMZEP00005005940 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (517 aa) |
| | ENSMZEP00005006099 | Histone H2B; Belongs to the histone H2B family. (155 aa) |
| | exo1 | Exonuclease 1. (790 aa) |
| | ENSMZEP00005008162 | Reverse transcriptase domain-containing protein. (405 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (507 aa) |
| | rpa2 | Replication protein A2. (293 aa) |
| | LOC101474040 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa) |
| | LOC101479826 | Small ubiquitin-related modifier. (94 aa) |
| | LOC101482023 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (530 aa) |
| | ENSMZEP00005010693 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | LOC101482995 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (435 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (391 aa) |
| | ENSMZEP00005013991 | Histone H2B; Belongs to the histone H2B family. (155 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (176 aa) |
| | ENSMZEP00005015169 | Uncharacterized protein. (146 aa) |
| | ENSMZEP00005015178 | Uncharacterized protein. (200 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1401 aa) |
| | LOC101467337-3 | Histone H4. (103 aa) |
| | LOC112433862 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (315 aa) |
| | ENSMZEP00005016530 | TAN domain-containing protein. (177 aa) |
| | Atm | Uncharacterized protein. (139 aa) |
| | ENSMZEP00005017141 | Reverse transcriptase domain-containing protein. (781 aa) |
| | sumo2 | Rad60-SLD domain-containing protein. (71 aa) |
| | ENSMZEP00005017386 | Histone H2B; Belongs to the histone H2B family. (110 aa) |
| | ENSMZEP00005018137 | Reverse transcriptase domain-containing protein. (758 aa) |
| | Brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (278 aa) |
| | ENSMZEP00005019039 | AAA_23 domain-containing protein. (53 aa) |
| | ENSMZEP00005019048 | Uncharacterized protein. (255 aa) |
| | ENSMZEP00005020374 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (226 aa) |
| | ENSMZEP00005020665 | Reverse transcriptase domain-containing protein. (792 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1709 aa) |
| | LOC112430055 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (658 aa) |
| | LOC101466501 | Histone H2A; Belongs to the histone H2A family. (138 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (557 aa) |
| | ENSMZEP00005022867 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (230 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | mdc1 | Uncharacterized protein. (2077 aa) |
| | ENSMZEP00005024534 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (99 aa) |
| | LOC112430600 | Reverse transcriptase domain-containing protein. (1080 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1514 aa) |
| | ube2n | Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (167 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (378 aa) |
| | ENSMZEP00005025280 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa) |
| | ENSMZEP00005025745 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | rad1 | RAD1 homolog (S. pombe). (279 aa) |
| | Rbbp8 | SAE2 domain-containing protein. (75 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | ENSMZEP00005028166 | Uncharacterized protein; Belongs to the histone H2A family. (230 aa) |
| | ENSMZEP00005028170 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | ENSMZEP00005028176 | Reverse transcriptase domain-containing protein. (402 aa) |
| | brca1 | Uncharacterized protein. (1389 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (630 aa) |
| | ENSMZEP00005028890 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (144 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | blm | BLM RecQ like helicase. (1381 aa) |
| | timeless | Timeless circadian clock. (1249 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | ENSMZEP00005030060 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (97 aa) |
| | nbn | Nibrin. (843 aa) |
| | rmi2 | RecQ mediated genome instability 2. (146 aa) |
| | ENSMZEP00005031292 | Reverse transcriptase domain-containing protein. (313 aa) |
| | ENSMZEP00005031506 | Protein kinase domain-containing protein. (424 aa) |
| | LOC101485310 | Ubiquitin-like domain-containing protein. (139 aa) |
| | LOC101467722 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1926 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | LOC112434231 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (311 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (957 aa) |
| | ENSMZEP00005033089 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (164 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa) |
| | LOC106675665 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ENSMZEP00005033184 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa) |
| | ENSMZEP00005033186 | Uncharacterized protein; Belongs to the histone H2A family. (244 aa) |
| | ENSMZEP00005033214 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ENSMZEP00005033215 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa) |
| | LOC101468538 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | sirt6 | Sirtuin 6. (351 aa) |
| | LOC101466600 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (679 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (398 aa) |
| | atrip | Uncharacterized protein. (789 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | ENSMZEP00005001347 | Uncharacterized protein; Belongs to the histone H2A family. (247 aa) |
| | ENSMZEP00005001383 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | LOC101467042 | Histone H2B 1/2. (124 aa) |
| | LOC101473203 | Uncharacterized protein. (428 aa) |
| | ENSMZEP00005035748 | RecQ helicase-like 4. (770 aa) |
| | ENSMZEP00005035951 | Uncharacterized protein. (162 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (356 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (608 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (544 aa) |
| | ENSMZEP00005001705 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa) |
| | ENSMZEP00005001914 | Reverse transcriptase domain-containing protein. (1007 aa) |
| | LOC101467042-2 | Histone H2B 1/2. (124 aa) |
| | LOC101472185 | Small ubiquitin-related modifier. (94 aa) |
| | rnf169 | Ring finger protein 169. (585 aa) |
| | LOC101467042-3 | Histone H2B 1/2. (124 aa) |
| | LOC101467337 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC101467337-2 | Histone H4. (103 aa) |
| | ENSMZEP00005002309 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa) |
| | ENSMZEP00005002594 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa) |
| | ENSMZEP00005002637 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (83 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2848 aa) |
| | ENSMZEP00005002744 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa) |
| | rhno1 | Uncharacterized protein. (295 aa) |
| | Rad9b | Uncharacterized protein. (124 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
