STRINGSTRING
anapc2 anapc2 psmd5 psmd5 anapc7 anapc7 LOC101477005 LOC101477005 pole2 pole2 orc5 orc5 cdc27 cdc27 rbx1 rbx1 LOC101466637 LOC101466637 PSMA5 PSMA5 RCBTB1 RCBTB1 rfc5 rfc5 cdc16 cdc16 pola1 pola1 LOC101481073 LOC101481073 anapc4 anapc4 anapc1 anapc1 psme2 psme2 psmd7 psmd7 kxd1 kxd1 psmb4 psmb4 LOC101476208 LOC101476208 cdt1 cdt1 orc1 orc1 rpa3 rpa3 psmd1 psmd1 psma3 psma3 psmc4 psmc4 cdc23 cdc23 ube2e1 ube2e1 LOC101471788 LOC101471788 pole3 pole3 mcm2 mcm2 psmd13 psmd13 pole pole ube2s ube2s uba52 uba52 LOC101480162 LOC101480162 LOC101480459 LOC101480459 orc4 orc4 gins3 gins3 psmc5 psmc5 psmb8 psmb8 LOC101467722 LOC101467722 lig1 lig1 fen1 fen1 psmd8 psmd8 bicra bicra ccna1 ccna1 rfc3 rfc3 RPA1 RPA1 mcm4 mcm4 psma8 psma8 FZR1 FZR1 LOC101473263 LOC101473263 ENSMZEP00005034410 ENSMZEP00005034410 tm7sf3 tm7sf3 psmc6 psmc6 prim1 prim1 CCNE2 CCNE2 LOC101476670 LOC101476670 psmb2 psmb2 LOC101479706 LOC101479706 rfc2 rfc2 mcm8 mcm8 LOC101466438 LOC101466438 mcm9 mcm9 LOC112432202 LOC112432202 PSMC2 PSMC2 LOC101472814 LOC101472814 rfc4 rfc4 orc2 orc2 atad5 atad5 skp2 skp2 psmc3 psmc3 psmb1 psmb1 LOC112436452 LOC112436452 pold1 pold1 pold2 pold2 LOC101471805 LOC101471805 pcna pcna pole4 pole4 LOC101474768 LOC101474768 mcm7 mcm7 LOC101485033 LOC101485033 LOC101476664 LOC101476664 LOC101470307 LOC101470307 skp1 skp1 LOC101470123 LOC101470123 LOC101483887 LOC101483887 meiob meiob LOC101482023 LOC101482023 LOC101473243 LOC101473243 LOC101470828 LOC101470828 rpa1 rpa1 psmd10 psmd10 anapc15 anapc15 psme3 psme3 psma2 psma2 rpa2 rpa2 psmc1 psmc1 LOC101472537 LOC101472537 LOC101472230 LOC101472230 pold3 pold3 psme4 psme4 LOC101465041 LOC101465041 fam89a fam89a psmd14 psmd14 prim2 prim2 cdc6 cdc6 orc3 orc3 anapc5 anapc5 LOC101485698 LOC101485698 LOC101485013 LOC101485013 psmd3 psmd3 bicral bicral rps27a rps27a mcm5 mcm5 gins1 gins1 pola2 pola2 gmnn gmnn gins4 gins4 dna2 dna2 LOC101474241 LOC101474241 LOC112429995 LOC112429995 ube2c ube2c psmd6 psmd6 psme1 psme1 gins2 gins2 psmb3 psmb3 psma1 psma1 LOC101485137 LOC101485137 rfc1 rfc1 ENSMZEP00005031506 ENSMZEP00005031506 cdc26 cdc26 mcm3 mcm3 LOC101464547 LOC101464547 cdk2 cdk2 ENSMZEP00005016904 ENSMZEP00005016904 cul1 cul1 psma4 psma4 pold4 pold4 LOC101485859 LOC101485859 psma5 psma5 anapc16 anapc16 psmd9 psmd9 psmd12 psmd12 ccne1 ccne1 ENSMZEP00005002796 ENSMZEP00005002796 ENSMZEP00005002804 ENSMZEP00005002804
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (819 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
LOC101477005Cyclin A2; Belongs to the cyclin family. (434 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
orc5Origin recognition complex, subunit 5. (445 aa)
cdc27Cell division cycle 27. (811 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
LOC101466637WD_REPEATS_REGION domain-containing protein. (489 aa)
PSMA5Proteasome subunit alpha type. (221 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (637 aa)
pola1DNA polymerase. (1482 aa)
LOC101481073Proteasome subunit beta. (292 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa)
anapc1Anaphase promoting complex subunit 1. (1981 aa)
psme2Proteasome activator subunit 2. (245 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (330 aa)
kxd1KxDL motif containing 1. (192 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
LOC101476208PCI domain-containing protein. (422 aa)
cdt1Chromatin licensing and DNA replication factor 1. (599 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (899 aa)
rpa3Replication protein A3. (122 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (957 aa)
psma3Proteasome subunit alpha type. (255 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (575 aa)
ube2e1Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
LOC101471788UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (379 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (212 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
LOC101480162UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
LOC101480459Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
gins3GINS complex subunit 3. (211 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (407 aa)
psmb8Proteasome subunit beta. (275 aa)
LOC101467722Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
lig1DNA ligase. (1013 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1877 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (398 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
psma8Proteasome subunit alpha type. (251 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (496 aa)
LOC101473263Proteasome inhibitor subunit 1. (261 aa)
ENSMZEP00005034410Uncharacterized protein. (277 aa)
tm7sf3Transmembrane 7 superfamily member 3. (568 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (411 aa)
LOC101476670DNA helicase; Belongs to the MCM family. (828 aa)
psmb2Proteasome subunit beta. (199 aa)
LOC101479706Proteasome 26S subunit, non-ATPase 4a. (372 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (868 aa)
LOC101466438Proteasome subunit beta. (248 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1169 aa)
LOC112432202Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (382 aa)
LOC101472814Proteasome subunit beta. (275 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
orc2Uncharacterized protein. (576 aa)
atad5ATPase family AAA domain containing 5a. (1807 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (397 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (476 aa)
psmb1Proteasome subunit beta. (237 aa)
LOC112436452DNA helicase; Belongs to the MCM family. (828 aa)
pold1DNA polymerase. (1105 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
LOC101471805Proteasome subunit beta. (286 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
LOC101474768SCY domain-containing protein. (125 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (740 aa)
LOC101485033Fizzy/cell division cycle 20 related 1b. (487 aa)
LOC101476664Proteasome subunit beta. (278 aa)
LOC101470307Cyclin E2; Belongs to the cyclin family. (391 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC101470123Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (182 aa)
LOC101483887Proteasome subunit alpha type. (246 aa)
meiobMethionine sulfoxide reductase B1b. (459 aa)
LOC101482023Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (530 aa)
LOC101473243Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (381 aa)
LOC101470828Proteasome 26S subunit, non-ATPase 11b. (422 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (243 aa)
anapc15Anaphase promoting complex subunit 15. (122 aa)
psme3Proteasome activator subunit 3. (256 aa)
psma2Proteasome subunit alpha type. (234 aa)
rpa2Replication protein A2. (293 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
LOC101472537Proteasome subunit beta 12. (217 aa)
LOC101472230Proteasome subunit beta. (216 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa)
psme4Proteasome activator subunit 4a. (1847 aa)
LOC101465041Proteasome subunit alpha type. (246 aa)
fam89aFamily with sequence similarity 89 member A. (180 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (602 aa)
orc3Origin recognition complex, subunit 3. (720 aa)
anapc5Anaphase promoting complex subunit 5. (771 aa)
LOC101485698Zgc:110269. (348 aa)
LOC101485013Proteasome subunit alpha type. (248 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (522 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (803 aa)
rps27aRibosomal protein S27a. (192 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (196 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
gmnnGeminin DNA replication inhibitor. (233 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
dna2DNA replication helicase/nuclease 2. (1401 aa)
LOC101474241RING-type domain-containing protein. (94 aa)
LOC112429995Anaphase-promoting complex subunit 11. (84 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
psme1Proteasome activator subunit 1. (255 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (175 aa)
psmb3Proteasome subunit beta. (205 aa)
psma1Proteasome subunit alpha type. (263 aa)
LOC101485137AAA domain-containing protein. (853 aa)
rfc1Replication factor C subunit 1. (1161 aa)
ENSMZEP00005031506Protein kinase domain-containing protein. (424 aa)
cdc26Cell division cycle 26 homolog. (97 aa)
mcm3DNA helicase; Belongs to the MCM family. (811 aa)
LOC101464547Proteasome 26S subunit, non-ATPase 4b. (375 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ENSMZEP00005016904Proteasome subunit beta. (278 aa)
cul1Cullin 1b; Belongs to the cullin family. (776 aa)
psma4Proteasome subunit alpha type. (261 aa)
pold4Si:dkey-28b4.7. (107 aa)
LOC101485859Proteasome subunit beta. (281 aa)
psma5Proteasome subunit alpha type. (243 aa)
anapc16Anaphase promoting complex subunit 16. (108 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (204 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (508 aa)
ENSMZEP00005002796BLM10_mid domain-containing protein. (567 aa)
ENSMZEP00005002804DUF3437 domain-containing protein. (320 aa)
Your Current Organism:
Maylandia zebra
NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna
Server load: low (36%) [HD]