79 items (Maylandia zebra) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101464967	Glutathione S-transferase theta 1b; Belongs to the GST superfamily. (241 aa)
	mgst2	Microsomal glutathione S-transferase 2. (138 aa)
	LOC101471489	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (647 aa)
	umps	Uridine monophosphate synthetase. (485 aa)
	upb1	Ureidopropionase, beta. (383 aa)
	uck1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (275 aa)
	rrm2b	Ribonucleotide reductase M2 b. (349 aa)
	LOC101471779	NDK domain-containing protein; Belongs to the NDK family. (149 aa)
	LOC101469101	Glutathione S-transferase. (222 aa)
	LOC101469751	Glutathione S-transferase. (220 aa)
	CMPK1	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (219 aa)
	LOC101464300	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (611 aa)
	LOC101482061-2	Uncharacterized protein; Belongs to the arylamine N-acetyltransferase family. (290 aa)
	LOC101481779	Uncharacterized protein; Belongs to the arylamine N-acetyltransferase family. (290 aa)
	hprt1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	LOC101466690	Uridine-cytidine kinase; Belongs to the uridine kinase family. (545 aa)
	LOC101478274	Microsomal glutathione S-transferase 3b. (140 aa)
	LOC101487835	Nucleoside diphosphate kinase. (152 aa)
	GSTM3	Glutathione S-transferase mu 3. (217 aa)
	LOC101479547	Uncharacterized protein; Belongs to the GST superfamily. (203 aa)
	LOC101464260	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	dut	Deoxyuridine triphosphatase. (181 aa)
	LOC101484275	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
	tk1	Thymidine kinase. (233 aa)
	nme7	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (379 aa)
	upp2	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (313 aa)
	mgst3	Microsomal glutathione S-transferase 3a. (150 aa)
	LOC101481213	Uridine-cytidine kinase; Belongs to the uridine kinase family. (262 aa)
	mgst1	Microsomal glutathione S-transferase 1.2. (151 aa)
	LOC101483765	Nucleoside diphosphate kinase. (201 aa)
	dpyd	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1021 aa)
	LOC101473239	Uridine-cytidine kinase; Belongs to the uridine kinase family. (262 aa)
	LOC106674493	Uncharacterized protein; Belongs to the GST superfamily. (224 aa)
	LOC106674774	Uncharacterized protein; Belongs to the GST superfamily. (223 aa)
	LOC101475730	Glutathione S-transferase rho; Belongs to the GST superfamily. (224 aa)
	LOC101475427	Uncharacterized protein; Belongs to the GST superfamily. (230 aa)
	LOC101474657	Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
	LOC101474942	Glutathione S-transferase rho; Belongs to the GST superfamily. (226 aa)
	LOC106674783	Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
	LOC101470694	Glutathione S-transferase rho; Belongs to the GST superfamily. (230 aa)
	LOC101474387	Glutathione S-transferase rho; Belongs to the GST superfamily. (225 aa)
	LOC101479487	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (581 aa)
	LOC106675324	Uncharacterized protein. (326 aa)
	xdh	Xanthine dehydrogenase. (1355 aa)
	gmps	Guanine monophosphate synthase. (690 aa)
	dpys	Dihydropyrimidinase. (496 aa)
	ugt1a1	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	ENSMZEP00005018502	Uncharacterized protein. (383 aa)
	LOC101479386	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	ENSMZEP00005018551	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (385 aa)
	RRM2-2	Ribonucleotide reductase regulatory subunit M2. (385 aa)
	LOC101471226	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa)
	nme6	Nucleoside diphosphate kinase. (182 aa)
	LOC101481005	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (793 aa)
	LOC101476861	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (793 aa)
	ENSMZEP00005023850	COesterase domain-containing protein. (90 aa)
	tk2	Thymidine kinase 2. (271 aa)
	TYMP	Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (452 aa)
	itpa	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (205 aa)
	LOC101471679	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (592 aa)
	ENSMZEP00005026831	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (526 aa)
	LOC101482242	Glutathione S-transferase theta 1a; Belongs to the GST superfamily. (243 aa)
	LOC101485158	Glutathione S-transferase theta 2; Belongs to the GST superfamily. (228 aa)
	impdh2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (538 aa)
	LOC101478600	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (558 aa)
	uckl1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (551 aa)
	LOC101477863	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (640 aa)
	LOC101468076	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (524 aa)
	LOC101468383	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (524 aa)
	LOC101468674	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	tpmt	Uncharacterized protein. (233 aa)
	LOC101476695	Uridine-cytidine kinase; Belongs to the uridine kinase family. (517 aa)
	cda	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (165 aa)
	LOC101486407	Uncharacterized protein; Belongs to the GST superfamily. (239 aa)
	GSTO1	Uncharacterized protein; Belongs to the GST superfamily. (239 aa)
	GSTO1-2	Uncharacterized protein. (239 aa)
	ENSMZEP00005037469	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (228 aa)
	LOC101473569	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (618 aa)

Your Current Organism:

Maylandia zebra

NCBI taxonomy Id: 106582
Other names: M. zebra, Metriaclima zebra, Pseudotropheus zebra, zebra mbuna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMPK1	ENSMZEP00005037469	ENSMZEP00005007156	ENSMZEP00005037469	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	0.940
CMPK1	LOC101466690	ENSMZEP00005007156	ENSMZEP00005008280	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.934
CMPK1	LOC101471779	ENSMZEP00005007156	ENSMZEP00005005440	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	NDK domain-containing protein; Belongs to the NDK family.	0.939
CMPK1	LOC101473239	ENSMZEP00005007156	ENSMZEP00005014525	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.929
CMPK1	LOC101476695	ENSMZEP00005007156	ENSMZEP00005035309	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.934
CMPK1	LOC101476861	ENSMZEP00005007156	ENSMZEP00005022374	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.944
CMPK1	LOC101481005	ENSMZEP00005007156	ENSMZEP00005021391	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.944
CMPK1	LOC101481213	ENSMZEP00005007156	ENSMZEP00005013191	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.929
CMPK1	LOC101483765	ENSMZEP00005007156	ENSMZEP00005014162	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Nucleoside diphosphate kinase.	0.951
CMPK1	LOC101487835	ENSMZEP00005007156	ENSMZEP00005008995	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Nucleoside diphosphate kinase.	0.939
CMPK1	RRM2	ENSMZEP00005007156	ENSMZEP00005019010	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Ribonucleotide reductase regulatory subunit M2.	0.928
CMPK1	RRM2-2	ENSMZEP00005007156	ENSMZEP00005019064	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Ribonucleotide reductase regulatory subunit M2.	0.928
CMPK1	dut	ENSMZEP00005007156	ENSMZEP00005009965	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Deoxyuridine triphosphatase.	0.941
CMPK1	nme6	ENSMZEP00005007156	ENSMZEP00005021375	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Nucleoside diphosphate kinase.	0.939
CMPK1	nme7	ENSMZEP00005007156	ENSMZEP00005011223	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Nucleoside diphosphate kinase 7; Belongs to the NDK family.	0.939
CMPK1	rrm2b	ENSMZEP00005007156	ENSMZEP00005004424	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Ribonucleotide reductase M2 b.	0.928
CMPK1	tk1	ENSMZEP00005007156	ENSMZEP00005010768	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Thymidine kinase.	0.924
CMPK1	tk2	ENSMZEP00005007156	ENSMZEP00005024797	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Thymidine kinase 2.	0.929
CMPK1	uck1	ENSMZEP00005007156	ENSMZEP00005003671	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.929
CMPK1	uckl1	ENSMZEP00005007156	ENSMZEP00005031610	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.934