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lepA lepA cysA cysA ruvB ruvB hda hda lolD lolD radA radA ftsH ftsH typA typA ARG15701.1 ARG15701.1 ARG18705.1 ARG18705.1 ARG18700.1 ARG18700.1 aroK aroK ARG15503.1 ARG15503.1 ARG15300.1 ARG15300.1 ARG18655.1 ARG18655.1 atpA atpA atpD atpD ARG18548.1 ARG18548.1 coaE coaE infB infB ARG18462.1 ARG18462.1 ARG18461.1 ARG18461.1 clpX clpX der der macB macB holA holA ARG18187.1 ARG18187.1 apbC apbC fusA fusA mnmE mnmE tuf tuf rep rep ARG17970.1 ARG17970.1 ARG17969.1 ARG17969.1 ARG17822.1 ARG17822.1 ureG ureG adk adk lon lon purA purA clpB clpB lptB lptB ARG17559.1 ARG17559.1 ARG17530.1 ARG17530.1 artP artP msbA msbA cmk cmk ARG17094.1 ARG17094.1 metN metN tsaE tsaE ntrC ntrC recA recA ftsY ftsY pyrG pyrG ARG16542.1 ARG16542.1 ARG16485.1 ARG16485.1 rhlB rhlB ARG16433.1 ARG16433.1 ARG16412.1 ARG16412.1 ARG16289.1 ARG16289.1 pstB pstB rapA rapA obg obg uvrB uvrB era era
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lepAElongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (605 aa)
cysASulfate ABC transporter ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (353 aa)
ruvBHolliday junction branch migration DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
hdaDnaA regulatory inactivator Hda; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DnaA family. HdA subfamily. (232 aa)
lolDLipoprotein ABC transporter ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (228 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (462 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (642 aa)
typATranslational GTPase TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (611 aa)
ARG15701.1GTP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
ARG18705.1PhoH family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
ARG18700.1Phospholipid ABC transporter ATP-binding protein MlaF; ABC transporter maintaining outer membrane lipid asymmetry; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (189 aa)
ARG15503.1Energy-dependent translational throttle protein EttA; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
ARG15300.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
ARG18655.1Cobalamin biosynthesis protein CobQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (514 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (464 aa)
ARG18548.1Ferrous iron transporter B; Derived by automated computational analysis using gene prediction method: Protein Homology. (618 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (899 aa)
ARG18462.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
ARG18461.1DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
clpXATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (437 aa)
derRibosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (469 aa)
macBMacrolide ABC transporter permease/ATP-binding protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (664 aa)
holADNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
ARG18187.1RNase adaptor protein RapZ; Displays ATPase and GTPase activities. (283 aa)
apbCATP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (409 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (712 aa)
mnmEtRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (451 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa)
repATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (679 aa)
ARG17970.1Type IV pili twitching motility protein PilT; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
ARG17969.1Twitching motility protein PilT; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
ARG17822.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
ureGUrease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. (204 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
lonEndopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (809 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (439 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (859 aa)
lptBLPS export ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ARG17559.1Type I secretion system permease/ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (711 aa)
ARG17530.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
artPDcaP-like protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
msbALipid A export permease/ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (575 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
ARG17094.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
metNMethionine ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (341 aa)
tsaEtRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
ntrCNitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (497 aa)
recADNA recombination/repair protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (350 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (368 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
ARG16542.1Molybdenum ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
ARG16485.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
rhlBATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (389 aa)
ARG16433.1Histidine/lysine/arginine/ornithine ABC transporter ATP-binding protein HisP; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
ARG16412.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
ARG16289.1ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (872 aa)
pstBPhosphate ABC transporter ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (300 aa)
rapARNA polymerase-associated protein RapA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (945 aa)
obgGTPase ObgE; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (406 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (673 aa)
eraGTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (340 aa)
Your Current Organism:
Acinetobacter nosocomialis
NCBI taxonomy Id: 106654
Other names: A. nosocomialis, Acinetobacter genomosp. 13TU, Acinetobacter genosp. 13TU, Acinetobacter nosocomialis Nemec et al. 2011, Acinetobacter sp. NF108071, Acinetobacter sp. WC-487, CCM 7791, CCUG 74064, LMG 10619, LMG:10619, NIPH 2119, strain RUH 2376
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