(13 nodes) DNA ligase (ATP) activity network (Amycolatopsis methanolica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Your Input:
	ku	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (326 aa)
	lig	DNA ligase, ATP-dependent. (237 aa)
	lig-2	ATP dependent DNA ligase. (357 aa)
	lig-3	DNA polymerase LigD, polymerase domain protein. (331 aa)
	lig-4	ATP-dependent DNA ligase. (309 aa)
	lig-5	DNA polymerase LigD, polymerase domain-containing protein. (319 aa)
	lig-6	DNA polymerase LigD, polymerase domain-containing protein. (309 aa)
	lig-7	ATP-dependent DNA ligase. (395 aa)
	lig-8	DNA polymerase LigD, ligase domain-containing protein. (357 aa)
	lig-9	DNA polymerase LigD, polymerase domain-containing protein. (339 aa)
	lig-10	DNA ligase D/DNA polymerase LigD. (352 aa)
	ku-2	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (285 aa)
	AIJ25344.1	DNA polymerase LigD, ligase domain protein. (333 aa)

Your Current Organism:

Amycolatopsis methanolica

NCBI taxonomy Id: 1068978
Other names: A. methanolica 239, Amycolatopsis methanolica 239, Amycolatopsis methanolica IFO 15065, Amycolatopsis methanolica IMSNU 20055, Amycolatopsis methanolica KCTC 9411, Amycolatopsis methanolica NCIB 11946, Amycolatopsis methanolica NRRL B-24139, Amycolatopsis methanolica str. 239, Amycolatopsis methanolica strain 239

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIJ25344.1	ku	AMETH_5252	AMETH_0281	DNA polymerase LigD, ligase domain protein.	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.836
AIJ25344.1	ku-2	AMETH_5252	AMETH_5205	DNA polymerase LigD, ligase domain protein.	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.836
AIJ25344.1	lig-10	AMETH_5252	AMETH_4914	DNA polymerase LigD, ligase domain protein.	DNA ligase D/DNA polymerase LigD.	0.927
AIJ25344.1	lig-3	AMETH_5252	AMETH_0590	DNA polymerase LigD, ligase domain protein.	DNA polymerase LigD, polymerase domain protein.	0.978
AIJ25344.1	lig-4	AMETH_5252	AMETH_1315	DNA polymerase LigD, ligase domain protein.	ATP-dependent DNA ligase.	0.997
AIJ25344.1	lig-5	AMETH_5252	AMETH_1718	DNA polymerase LigD, ligase domain protein.	DNA polymerase LigD, polymerase domain-containing protein.	0.977
AIJ25344.1	lig-6	AMETH_5252	AMETH_2185	DNA polymerase LigD, ligase domain protein.	DNA polymerase LigD, polymerase domain-containing protein.	0.978
AIJ25344.1	lig-7	AMETH_5252	AMETH_3587	DNA polymerase LigD, ligase domain protein.	ATP-dependent DNA ligase.	0.997
AIJ25344.1	lig-9	AMETH_5252	AMETH_4732	DNA polymerase LigD, ligase domain protein.	DNA polymerase LigD, polymerase domain-containing protein.	0.978
ku	AIJ25344.1	AMETH_0281	AMETH_5252	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	DNA polymerase LigD, ligase domain protein.	0.836
ku	ku-2	AMETH_0281	AMETH_5205	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.914
ku	lig	AMETH_0281	AMETH_0282	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	DNA ligase, ATP-dependent.	0.905
ku	lig-10	AMETH_0281	AMETH_4914	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	DNA ligase D/DNA polymerase LigD.	0.835
ku	lig-2	AMETH_0281	AMETH_0589	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	ATP dependent DNA ligase.	0.860
ku	lig-3	AMETH_0281	AMETH_0590	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	DNA polymerase LigD, polymerase domain protein.	0.866
ku	lig-4	AMETH_0281	AMETH_1315	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	ATP-dependent DNA ligase.	0.873
ku	lig-5	AMETH_0281	AMETH_1718	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	DNA polymerase LigD, polymerase domain-containing protein.	0.858
ku	lig-6	AMETH_0281	AMETH_2185	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	DNA polymerase LigD, polymerase domain-containing protein.	0.866
ku	lig-7	AMETH_0281	AMETH_3587	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	ATP-dependent DNA ligase.	0.872
ku	lig-8	AMETH_0281	AMETH_4727	Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	DNA polymerase LigD, ligase domain-containing protein.	0.864

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