STRINGSTRING
bioF bioF AIJ24400.1 AIJ24400.1 AIJ24310.1 AIJ24310.1 AIJ24124.1 AIJ24124.1 hemL-3 hemL-3 AIJ23694.1 AIJ23694.1 AIJ23693.1 AIJ23693.1 metH-2 metH-2 mdlC mdlC ilvA-3 ilvA-3 bioF-2 bioF-2 bioA bioA AIJ23206.1 AIJ23206.1 AIJ23074.1 AIJ23074.1 gabT gabT metH metH lysA-2 lysA-2 AIJ22806.1 AIJ22806.1 argD argD AIJ22627.1 AIJ22627.1 AIJ22522.1 AIJ22522.1 ilvB-2 ilvB-2 AIJ22087.1 AIJ22087.1 gabT2 gabT2 aspC-2 aspC-2 thrC-2 thrC-2 metY metY ilvB ilvB iscS iscS thrC thrC lysA lysA dapC dapC AIJ20974.1 AIJ20974.1 mutB mutB mutA mutA alr alr aspC aspC AIJ20694.1 AIJ20694.1 ilvA-2 ilvA-2 AIJ20663.1 AIJ20663.1 hemL-2 hemL-2 korB korB menD menD hemL hemL AIJ20484.1 AIJ20484.1 AIJ20481.1 AIJ20481.1 AIJ20456.1 AIJ20456.1 poxB poxB hisC hisC metB metB ilvA ilvA AIJ24401.1 AIJ24401.1 AIJ24472.1 AIJ24472.1 ilvA-4 ilvA-4 glyA glyA AIJ24808.1 AIJ24808.1 rocD rocD dxs dxs mcm mcm speC speC AIJ25110.1 AIJ25110.1 AIJ25160.1 AIJ25160.1 hisC-2 hisC-2 poxB-2 poxB-2 trpB-2 trpB-2 hisC-3 hisC-3 bioA2 bioA2 thrC-3 thrC-3 glgP glgP AIJ25741.1 AIJ25741.1 ilvB-3 ilvB-3 gabT-2 gabT-2 ilvB-4 ilvB-4 metY-2 metY-2 AIJ25840.1 AIJ25840.1 kgd kgd tbpA tbpA ilvA-5 ilvA-5 metB-2 metB-2 AIJ26007.1 AIJ26007.1 AIJ26008.1 AIJ26008.1 AIJ26009.1 AIJ26009.1 AIJ26105.1 AIJ26105.1 AIJ26158.1 AIJ26158.1 serC serC ectB ectB glyA-2 glyA-2 gadB gadB AIJ26802.1 AIJ26802.1 aspB aspB avtA avtA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bioF8-amino-7-oxononanoate synthase. (391 aa)
AIJ24400.1MOSC domain containing protein. (77 aa)
AIJ24310.1Hypothetical protein. (153 aa)
AIJ24124.1Oxidoreductase; Belongs to the iron/ascorbate-dependent oxidoreductase family. (237 aa)
hemL-3Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (384 aa)
AIJ23694.1Acetyltransferase, gnat family protein, putative. (57 aa)
AIJ23693.1GCN5-related N-acetyltransferase. (164 aa)
metH-2Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1180 aa)
mdlCBenzoylformate decarboxylase; Belongs to the TPP enzyme family. (522 aa)
ilvA-3Putative threonine dehydratase, PLP-dependent. (317 aa)
bioF-28-amino-7-oxononanoate synthase. (393 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (419 aa)
AIJ23206.1Amino acid racemase-like protein. (405 aa)
AIJ23074.1Pyridoxal-dependent decarboxylase. (436 aa)
gabT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1202 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (438 aa)
AIJ22806.1Non-ribosomal peptide synthetase. (1286 aa)
argDPutrescine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa)
AIJ22627.1Pyridoxal-5'-phosphate dependent enzyme; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (244 aa)
AIJ22522.1Methionine synthase. (590 aa)
ilvB-2Acetolactate synthase I/II/III large subunit; Belongs to the TPP enzyme family. (542 aa)
AIJ22087.1Pyridoxamine 5'-phosphate oxidase. (140 aa)
gabT2Class III aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa)
aspC-2Class I and II aminotransferase. (384 aa)
thrC-2Threonine synthase. (421 aa)
metYMethionine gamma-lyase. (430 aa)
ilvBAcetolactate synthase I/II/III large subunit. (581 aa)
iscSCysteine desulfurase. (398 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (354 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (478 aa)
dapCAminotransferase. (364 aa)
AIJ20974.1Pyridoxamine 5'-phosphate oxidase-like FMN-binding protein. (146 aa)
mutBmethylmalonyl-CoA mutase, small subunit. (722 aa)
mutAmethylmalonyl-CoA mutase, small subunit. (623 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (374 aa)
aspCAspartate aminotransferase. (408 aa)
AIJ20694.1Non-ribosomal peptide synthetase. (1127 aa)
ilvA-2Threonine dehydratase. (313 aa)
AIJ20663.1Transcriptional regulator, GntR family with aminotransferase domain. (127 aa)
hemL-2Putative glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (437 aa)
korB2-oxoglutarate synthase. (354 aa)
menD2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (554 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (407 aa)
AIJ20484.1Kynurenine--oxoglutarate transaminase. (388 aa)
AIJ20481.1GntR family transcriptional regulator. (456 aa)
AIJ20456.1Glutamate-1-semialdehyde-2,1-aminomutase. (119 aa)
poxBPyruvate dehydrogenase; Belongs to the TPP enzyme family. (595 aa)
hisCHistidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (350 aa)
metBCystathionine gamma-synthase. (346 aa)
ilvAEctoine utilization protein EutB. (318 aa)
AIJ24401.1MOSC domain containing protein. (129 aa)
AIJ24472.1Class V aminotransferase. (464 aa)
ilvA-4Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (419 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
AIJ24808.1Amino acid decarboxylase. (472 aa)
rocDAminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (401 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa)
mcmmethylmalonyl-CoA mutase, large subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1078 aa)
speCOrnithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (382 aa)
AIJ25110.1Hypothetical protein. (505 aa)
AIJ25160.1MOSC domain containing protein. (224 aa)
hisC-2Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
poxB-2Pyruvate dehydrogenase; Belongs to the TPP enzyme family. (574 aa)
trpB-2Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (450 aa)
hisC-3Histidinol-phosphate aminotransferase. (337 aa)
bioA2Adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (420 aa)
thrC-3Threonine synthase. (406 aa)
glgPGlycogen phosphorylase. (846 aa)
AIJ25741.1Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (388 aa)
ilvB-3Acetolactate synthase I/II/III large subunit; Belongs to the TPP enzyme family. (547 aa)
gabT-24-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (419 aa)
ilvB-4Acetolactate synthase I/II/III large subunit. (517 aa)
metY-2O-acetylhomoserine aminocarboxypropyltransferase. (434 aa)
AIJ25840.1Fe-S protein-like protein. (241 aa)
kgdAlpha-ketoglutarate decarboxylase. (1231 aa)
tbpAABC transporter substrate-binding protein. (346 aa)
ilvA-5Threonine dehydratase. (405 aa)
metB-2Methionine gamma-lyase. (385 aa)
AIJ26007.1Propanediol utilization: dehydratase, medium subunit. (196 aa)
AIJ26008.1Glycerol dehydratase large subunit. (562 aa)
AIJ26009.1Coenzyme B12-dependent glycerol dehydrogenase small subunit. (141 aa)
AIJ26105.1Pyridoxal-dependent decarboxylase. (478 aa)
AIJ26158.1Transcriptional regulator, GntR family with aminotransferase domain protein. (78 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (374 aa)
ectBDiaminobutyrate/2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (417 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
gadBGlutamate decarboxylase; Belongs to the group II decarboxylase family. (463 aa)
AIJ26802.1Hypothetical protein; Belongs to the TPP enzyme family. (566 aa)
aspBAminotransferase. (395 aa)
avtAValine-pyruvate aminotransferase. (437 aa)
Your Current Organism:
Amycolatopsis methanolica
NCBI taxonomy Id: 1068978
Other names: A. methanolica 239, Amycolatopsis methanolica 239, Amycolatopsis methanolica IFO 15065, Amycolatopsis methanolica IMSNU 20055, Amycolatopsis methanolica KCTC 9411, Amycolatopsis methanolica NCIB 11946, Amycolatopsis methanolica NRRL B-24139, Amycolatopsis methanolica str. 239, Amycolatopsis methanolica strain 239
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