STRINGSTRING
ruvA ruvA AIJ23643.1 AIJ23643.1 AIJ23922.1 AIJ23922.1 AIJ24148.1 AIJ24148.1 AIJ24182.1 AIJ24182.1 AIJ24690.1 AIJ24690.1 AIJ24871.1 AIJ24871.1 ku-2 ku-2 topA-2 topA-2 AIJ25821.1 AIJ25821.1 ku ku uvrD uvrD AIJ21083.1 AIJ21083.1 AIJ21117.1 AIJ21117.1 AIJ21118.1 AIJ21118.1 uvrD2 uvrD2 AIJ21620.1 AIJ21620.1 recG recG AIJ21650.1 AIJ21650.1 AIJ21711.1 AIJ21711.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa)
AIJ23643.1RecB family exonuclease. (288 aa)
AIJ23922.1TfoX N-terminal domain protein. (110 aa)
AIJ24148.1Transcriptional regulator. (69 aa)
AIJ24182.1DNA/RNA helicase, superfamily I. (764 aa)
AIJ24690.1Suppressor protein DnaK. (114 aa)
AIJ24871.1Nucleic acid binding protein. (125 aa)
ku-2DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (285 aa)
topA-2DNA topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...] (920 aa)
AIJ25821.1Alpha/beta hydrolase fold containing protein. (341 aa)
kuKu protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (326 aa)
uvrDATP-dependent DNA helicase PcrA. (801 aa)
AIJ21083.1RecB family exonuclease. (287 aa)
AIJ21117.1ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1069 aa)
AIJ21118.1ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1072 aa)
uvrD2ATP-dependent DNA helicase. (686 aa)
AIJ21620.1Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (211 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (717 aa)
AIJ21650.1DNA/RNA helicase, superfamily I. (709 aa)
AIJ21711.1Hypothetical protein. (250 aa)
Your Current Organism:
Amycolatopsis methanolica
NCBI taxonomy Id: 1068978
Other names: A. methanolica 239, Amycolatopsis methanolica 239, Amycolatopsis methanolica IFO 15065, Amycolatopsis methanolica IMSNU 20055, Amycolatopsis methanolica KCTC 9411, Amycolatopsis methanolica NCIB 11946, Amycolatopsis methanolica NRRL B-24139, Amycolatopsis methanolica str. 239, Amycolatopsis methanolica strain 239
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