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pdhC pdhC pdhB pdhB pdhA pdhA acs acs poxB poxB korB korB korA korA AIJ20930.1 AIJ20930.1 AIJ20960.1 AIJ20960.1 AIJ21404.1 AIJ21404.1 aceB aceB leuA leuA pyc pyc acyP acyP aceB-2 aceB-2 lldD1 lldD1 acs-2 acs-2 aceE aceE pdhC-2 pdhC-2 fadA-3 fadA-3 AIJ22974.1 AIJ22974.1 mhpF mhpF acs-3 acs-3 ackA ackA AIJ23184.1 AIJ23184.1 AIJ23264.1 AIJ23264.1 AIJ23267.1 AIJ23267.1 AIJ23288.1 AIJ23288.1 betB-6 betB-6 AIJ23317.1 AIJ23317.1 mdh mdh acdA2 acdA2 AIJ23748.1 AIJ23748.1 pdhA-2 pdhA-2 pdhB-2 pdhB-2 pdhA-3 pdhA-3 fadA-5 fadA-5 feaB feaB fadA-7 fadA-7 catF catF atoB atoB AIJ24655.1 AIJ24655.1 fumB fumB atoB-2 atoB-2 atoB-3 atoB-3 pyk pyk pdhD pdhD aceE-2 aceE-2 lldD lldD poxB-2 poxB-2 pdhD-3 pdhD-3 AIJ25443.1 AIJ25443.1 atoB-4 atoB-4 thcA-2 thcA-2 acs-5 acs-5 atoB-5 atoB-5 AIJ25828.1 AIJ25828.1 sfcA sfcA fumC fumC atoB-6 atoB-6 thcA-3 thcA-3 sfcA-2 sfcA-2 acs-6 acs-6 leuA-2 leuA-2 atoB-7 atoB-7 pckA pckA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdhCPyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component. (449 aa)
pdhBPyruvate dehydrogenase (acetyl-transferring). (342 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit. (410 aa)
acsdicarboxylate-CoA ligase PimA. (520 aa)
poxBPyruvate dehydrogenase; Belongs to the TPP enzyme family. (595 aa)
korB2-oxoglutarate synthase. (354 aa)
korA2-oxoglutarate ferredoxin oxidoreductase. (633 aa)
AIJ20930.1Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (477 aa)
AIJ20960.1acetyl-CoA carboxylase, biotin carboxylase. (599 aa)
AIJ21404.1Fumarate reductase/succinate dehydrogenase flavoprotein-like protein. (448 aa)
aceBMalate synthase; Belongs to the malate synthase family. (535 aa)
leuAAlpha-isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa)
pycPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
acyPAcylphosphatase. (110 aa)
aceB-2Malate synthase A; Belongs to the malate synthase family. (524 aa)
lldD1FMN-dependent (S)-2-hydroxy-acid oxidase. (393 aa)
acs-2AMP-dependent synthetase and ligase. (564 aa)
aceEPyruvate dehydrogenase complex, dehydrogenase (E1) component. (767 aa)
pdhC-2Dihydrolipoyllysine-residue succinyltransferase. (417 aa)
fadA-3acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (368 aa)
AIJ22974.1Beta-lactamase-like protein. (202 aa)
mhpFAcetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (303 aa)
acs-3O-succinylbenzoate-CoA ligase. (570 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (369 aa)
AIJ23184.1butyrate--CoA ligase. (309 aa)
AIJ23264.1acetyl-CoA acetyltransferase. (495 aa)
AIJ23267.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
AIJ23288.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
betB-6Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (500 aa)
AIJ23317.1acetyl-CoA acetyltransferase. (503 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
acdA2CoA-binding domain-containing protein. (693 aa)
AIJ23748.1Beta-lactamase-like protein. (460 aa)
pdhA-22-oxoisovalerate dehydrogenase E1 component, beta subunit. (627 aa)
pdhB-2Transketolase, central region. (329 aa)
pdhA-3Pyruvate dehydrogenase (acetyl-transferring). (323 aa)
fadA-5acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
feaBAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (485 aa)
fadA-7acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
catFacetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
atoBacetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
AIJ24655.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (461 aa)
fumBFumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (556 aa)
atoB-2acetyl-CoA acetyltransferase. (393 aa)
atoB-3acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (464 aa)
pdhDDihydrolipoamide dehydrogenase. (457 aa)
aceE-2Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (935 aa)
lldDL-lactate dehydrogenase. (403 aa)
poxB-2Pyruvate dehydrogenase; Belongs to the TPP enzyme family. (574 aa)
pdhD-3Dihydrolipoamide dehydrogenase. (465 aa)
AIJ25443.1L-lactate 2-monooxygenase. (387 aa)
atoB-4Beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
thcA-2Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (505 aa)
acs-5acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (603 aa)
atoB-5acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
AIJ25828.1acetyl/propionyl-CoA carboxylase, biotin carboxylase subunit fused with biotin carboxyl carrier subunit. (653 aa)
sfcAMalic enzyme. (406 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
atoB-6Beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
thcA-3Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
sfcA-2Malic enzyme. (464 aa)
acs-6acetate-CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (591 aa)
atoB-7acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (423 aa)
pckAPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (608 aa)
Your Current Organism:
Amycolatopsis methanolica
NCBI taxonomy Id: 1068978
Other names: A. methanolica 239, Amycolatopsis methanolica 239, Amycolatopsis methanolica IFO 15065, Amycolatopsis methanolica IMSNU 20055, Amycolatopsis methanolica KCTC 9411, Amycolatopsis methanolica NCIB 11946, Amycolatopsis methanolica NRRL B-24139, Amycolatopsis methanolica str. 239, Amycolatopsis methanolica strain 239
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